Prostacyclin and hormone levels in patients with symptoms of miscarriage and infection

Mitreski, Anita; Radeka, Gordana

doi:10.2298/mpns0210371m

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…When group B streptococci were injected into the amniotic fluid in preterm rhesus monkeys, amniotic fluid cytokine concentrations increased, followed by production of the prostaglandins E 2 and F 2α , and finally uterine contractions ( Gravett et al 1994 ). Similarly, in humans, preterm labor due to infection is thought to be initiated by cytokines, including interleukin-(IL)1, tumor necrosis factor, and IL-6, produced by macrophages ( Cram et al 2002 ; Mitreski and Radeka 2002 ; Narahara and Johnston 1993 ).…”

Section: Discussionmentioning

confidence: 99%

Exposures to Air Pollutants during Pregnancy and Preterm Delivery

Leem

Kaplan

Shim

et al. 2006

Environ Health Perspect

165

115

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The association between preterm delivery (PTD) and exposure to air pollutants has recently become a major concern. We investigated this relationship in Incheon, Republic of Korea, using spatial and temporal modeling to better infer individual exposures. The birth cohort consisted of 52,113 singleton births in 2001–2002, and data included residential address, gestational age, sex, birth date and order, and parental age and education. We used a geographic information system and kriging methods to construct spatial and temporal exposure models. Associations between exposure and PTD were evaluated using univariate and multivariate log-binomial regressions. Given the gestational age, birth date, and the mother’s residential address, we estimated each mother’s potential exposure to air pollutants during critical periods of the pregnancy. The adjusted risk ratios for PTD in the highest quartiles of the first trimester exposure were 1.26 [95% confidence interval (CI), 1.11–1.44] for carbon monoxide, 1.27 (95% CI, 1.04–1.56) for particulate matter with aerodynamic diameter ≤ 10 μm, 1.24 (95% CI, 1.09–1.41) for nitrogen dioxide, and 1.21 (95% CI, 1.04–1.42) for sulfur dioxide. The relationships between PTD and exposures to CO, NO2, and SO2 were dose dependent (p < 0.001, p < 0.02, p < 0.02, respectively). In addition, the results of our study indicated a significant association between air pollution and PTD during the third trimester of pregnancy. In conclusion, our study showed that relatively low concentrations of air pollution under current air quality standards during pregnancy may contribute to an increased risk of PTD. A biologic mechanism through increased prostaglandin levels that are triggered by inflammatory mediators during exposure periods is discussed.

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Section: Discussionmentioning

confidence: 99%

Exposures to Air Pollutants during Pregnancy and Preterm Delivery

Leem

Kaplan

Shim

et al. 2006

Environ Health Perspect

165

115

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“…1 ). Studies have shown direct relationships between increased prostacyclin levels and pregnancy complications including SAB 24 . Prostacyclin inhibits platelet activation and is a vasodilator.…”

Section: Discussionmentioning

confidence: 99%

Nonsteroidal Anti-inflammatory Drug Interaction with Prostacyclin Synthase Protects from Miscarriage

Edwards¹,

Edwards²,

Bray³

et al. 2017

Sci Rep

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This study evaluates the relationship between single nucleotide polymorphisms (SNPs) in nonsteroidal anti-inflammatory drug (NSAID) metabolism and related pathways and spontaneous abortion (SAB, gestation < 20 weeks) risk. Women were enrolled in Right from the Start (2004–2010) prospective cohort. Periconceptional NSAIDs reported through the sixth week of pregnancy were obtained from study interviews. We evaluated 201 SNPs in 600 European American women. Interaction analyses between NSAID use and SNPs were conducted using logistic regression, adjusted for confounders. We also evaluated prostaglandin E2 urinary metabolite (PGE-M) in an independent population for association with SNPs using linear regression. NSAID use was reported by 63% of cases and 62% controls. The most significant interaction was at prostacyclin synthase (PGIS) rs5602 (OR = 0.34, 95% CI 0.19–0.60, p = 2.45 × 10−4) and was significant after a Bonferroni correction. NSAID users were protected from SAB (OR = 0.78, 95% CI 0.56–1.10), while non-NSAID users were at increased risk (OR = 2.11, 95% CI 1.35–3.29) in rs5602 stratified analyses. rs5602 also associated with increased PGE-M levels (Beta = 0.09, 95% CI −0.002–0.19, p = 0.033). We identified an association between a PGIS variant and SAB risk that is modified by NSAIDs use during pregnancy and directly associated with increased levels of PGE metabolites. This suggests the potential use of genetic information to guide pharmaceutical intervention to prevent adverse pregnancy outcomes.

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“…When Group B streptococci were injected into the amnionic fluid in preterm rhesus monkeys, amnionic fluid cytokine concentrations increased, followed by production of the prostaglandins E 2 and F 2α and, finally, uterine contractions (Gravett et al, 1994). Similarly, in humans, preterm labor due to infection is thought to be initiated by cytokines, including interleukin-1 (IL-1), tumor necrosis factor, and interleukin-6, produced by macrophages (Cram et al, 2002;Narahara andJohnston 1993: Mitreski andRadeka 2002). Additionally, entry of PM into the body by this method may lead to oxidative inflammation in lungs and other organs, including the placenta, thereby increasing the susceptibility of the mother to begin preterm labor .…”

Section: Biological Mechanismmentioning

confidence: 99%