Prostacyclin and Pre-Eclampsia

Lewis, Peter J.; Shepherd, G.L.; Ritter, J.; Chan, Stephen M; Bolton, P.; Jogee, M.; Myatt, Leslie; Elder, M. G.

doi:10.1016/s0140-6736(81)92892-0

Cited by 56 publications

(6 citation statements)

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“…We previously reported that decreased eNOs expression contributes to increased endothelial permeability in preeclampsia (8). We and others also found reduced prostacyclin levels in the maternal blood and amniotic fluid in preeclampsia (4,25,26). Prostacyclin is a major vasodilator produced by endothelial cells.…”

Section: Discussionmentioning

confidence: 92%

Increased Superoxide Generation and Decreased Stress Protein Hsp90 Expression in Human Umbilical Cord Vein Endothelial Cells (HUVECs) from Pregnancies Complicated by Preeclampsia

Lewis

Zhang

et al. 2006

Hypertension in Pregnancy

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Section: Discussionmentioning

confidence: 92%

Increased Superoxide Generation and Decreased Stress Protein Hsp90 Expression in Human Umbilical Cord Vein Endothelial Cells (HUVECs) from Pregnancies Complicated by Preeclampsia

Lewis

Zhang

et al. 2006

Hypertension in Pregnancy

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“…It has recently been shown that trophoblast from carly pregnancies has a high capacity to synthesize PGT,, and it has been suggested that colonization of maternal blood vessels by trophoblast is facilitated by PG12. which may prevent platelet aggregates from halting this process (Lewis 1982). This theory might explain uur findings of elevated PG12M levels in early pregnancy.…”

Section: Discussionmentioning

confidence: 91%

Immunoreactive prostacyclin and thromboxane metabolites in normal pregnancy and the puerperium

Greer¹,

Walker

McLaren³

et al. 1985

BJOG

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Prostacyclin and thromboxane have been implicated in the pathophysiology of several disorders of pregnancy, but there is little information on concentrations of these prostaglandins in normal pregnancy. The aim of our study was to determine the range of values throughout normal pregnancy and the puerperium and to compare this with concentrations in normal non-pregnant women. Measurement was by radioimmunoassay of prostacyclin and thromboxane metabolites. We observed a significant difference in prostacyclin metabolites in the first trimester. (mean 19.9, §EM 0.96 pg/ml) compared with the normal non-pregnant group (mean 15.9. SEM 0.68 pgh1). There were no significant differences between values in the normal non-pregnant group and those in the second and third trimester or postnatally. The increase in prostacyclin in the first trimester may be associated with placent a t' ion and physiological vasodilation, and insencitivity to angiotensin 11 5een in early pregnancy. We noted a significant redaction in thromboxane metabolites in the second (mean 133, SEhl 14.9 pgirnl) and third (mean 123, SEM 30.7 pgiml) trimesters and the puerperium (mean 119, SEM 6.3 pgiml) compared with the values in the normal non-pregnant group (mean 142, SEM4.9pgiml). This may be due to increased platelet stability or decreased thromboxane synthesis. 20, 105-110. 389-399.

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“…However, combined realtime and pulsed Doppler ultrasound detected no changes in umbilical blood flow. In a case examined by Lewis et al, 19 prostacyclin infusion reduced maternal blood pressure slightly but the fetus died inexplicably. The investigators suggested that, had a fall in plasma 6-keto-PGF la been detected earlier, the outcome of prostacyclin infusion may have been more favorable.…”

Section: Discussionmentioning

confidence: 95%

A Prostacyclin Analogue Crosses the in Vitro Perfused Human Placenta and Improves Transfer in Some Pathologic States

Kuhn

Walenga²,

Stuart³

1991

Amer J Perinatol

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Placental blood flow is reduced in pregnancies complicated by hypertension, intrauterine growth retardation, maternal smoking, or diabetes. Umbilical-placental production of the potent vasodilator prostacyclin is also reduced in these pathologic states and this deficiency may contribute to an associated increase in the incidence of low infant birthweight by affecting a reduction in placental nutrient transfer. We have studied the effects of the prostacyclin analogue carbacyclin on diffusional transfer in the human placenta perfused in vitro. We have found that carbacyclin crosses the human placenta and can significantly increase diffusional transfer in placenta from pregnancies complicated by hypertension or maternal smoking and in the normal term placenta in which prostacyclin production has first been reduced through the administration of ibuprofen. Carbacyclin had no effect, however, in untreated placenta from normal pregnancies or in placenta from diabetic pregnancies. These results suggest that the prostacyclin-deficient perfused placenta may serve as a model for several placental insufficiency syndromes and that the possibility that prostacyclin analogues may improve deficient nutrient transfer in some pathologic pregnancies warrants further investigation.

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Prostacyclin and Pre-Eclampsia

Cited by 56 publications

References 0 publications

Increased Superoxide Generation and Decreased Stress Protein Hsp90 Expression in Human Umbilical Cord Vein Endothelial Cells (HUVECs) from Pregnancies Complicated by Preeclampsia

Increased Superoxide Generation and Decreased Stress Protein Hsp90 Expression in Human Umbilical Cord Vein Endothelial Cells (HUVECs) from Pregnancies Complicated by Preeclampsia

Immunoreactive prostacyclin and thromboxane metabolites in normal pregnancy and the puerperium

A Prostacyclin Analogue Crosses the in Vitro Perfused Human Placenta and Improves Transfer in Some Pathologic States

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