Prostaglandin D2 evokes potent uterine contraction via the F prostanoid receptor in postpartum rats

Hu, Chuangjia; Liu, Bin; Li, Hui; Wu, Xiangzhong; Guo, Tingting; Luo, Wei; Zhou, Yingbi

doi:10.1016/j.ejphar.2018.08.012

Cited by 8 publications

(9 citation statements)

References 33 publications

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“…Moreover, in mice with TP deficiency (TP −/− ), we have not only confirmed the involvement of TP in the PGI 2 ‐ or EDCF‐evoked responses, but also suggested that TP can be a common vasoconstrictor receptor of all other COX‐derived prostanoids, which per se implies that the activation of the receptor by PGI 2 results from the structural similarities inherited among prostanoids 49 . In fact, this may also explain why another prostanoid receptor, the F prostanoid receptor (the prototype receptor of PGF 2α ) is activated by non‐F prostanoids, such as PGD 2 , and other unexpected effects shown by many prostanoids or receptor antagonists 47,49,72–74 …”

Section: Pgi2's Emerging As a Major Edcf And Proposed Mechanisms For This Non‐classical Actionsupporting

confidence: 65%

Endothelium‐dependent contraction: The non‐classical action of endothelial prostacyclin, its underlying mechanisms, and implications

Liu

Zhou

2021

The FASEB Journal

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Section: Pgi2's Emerging As a Major Edcf And Proposed Mechanisms For This Non‐classical Actionsupporting

confidence: 65%

Endothelium‐dependent contraction: The non‐classical action of endothelial prostacyclin, its underlying mechanisms, and implications

Liu

Zhou

2021

The FASEB Journal

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“…PGD2 has been involved in different processes of female reproduction (Rossitto et al, 2015, Saito et al, 2002, and produced by the uterus, plays central roles in pregnancy maintenance (Helliwell et al, 2004) and in labour initiation and progression both in humans (Shiki et al, 2004) and in rats (Kengni et al, 2007). PGD2 has been implicated in COX-1-mediated labour initiation and parturition, since it induces prepartum myometrial contraction in vitro through the PGF2 receptor (FP) (Liu et al, 2017) and in vivo in rat endometrium (Hu et al, 2018). In the non-pregnant uterus, normal peristalsis depends on the responsiveness of prostanoid receptors that are heterogeneously distributed in the longitudinal and circular muscles of the myometrium.…”

Section: Discussionmentioning

confidence: 99%

“…In the non-pregnant uterus, normal peristalsis depends on the responsiveness of prostanoid receptors that are heterogeneously distributed in the longitudinal and circular muscles of the myometrium. The DP1 receptor together with EP2 and http://molehr.oxfordjournals.org/ prostaglandin I2 receptor, is categorised as a relaxant prostanoid receptor, in contrast to the contractile FP, EP1, EP3 receptors (Hu et al, 2018, Cao et al, 2002. The significant expression of both DP receptors in non-pregnant uteri (Catalano et al, 2011, Hu et al, 2018, particularly in the myometrium (Cao et al, 2002, Myatt andLye, 2004), is in agreement with our data.…”

Section: Discussionmentioning

confidence: 99%

In the mouse, prostaglandin D2 signalling protects the endometrium against adenomyosis

Philibert

Déjardin

Pirot

et al. 2021

Molecular Human Reproduction

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Adenomyosis is characterised by epithelial gland and mesenchymal stroma invasion of the uterine myometrium. Adenomyosis is an oestrogen-dependent gynaecological disease in which a number of factors, such as inflammatory molecules, prostaglandins (PGs), angiogenic factors, cell proliferation and extracellular matrix remodelling proteins also play a role as key disease mediators. In this study, we used mice lacking both L- and H-prostaglandin D synthase (Pgds) genes in which PGD2 is not produced to elucidate PGD2 roles in the uterus. Gene expression studied by real-time PCR and hormone dosages performed by ELISA or liquid chromatography tandem mass spectroscopy (LC-MS/MS) in mouse uterus samples, showed that components of the PGD2 signalling pathway, both PGDS and PGD2-receptors, are expressed in the mouse endometrium throughout the oestrus cycle with some differences among uterine compartments. We showed that PGE2 production and the steroidogenic pathway are dysregulated in the absence of PGD2. Histological analysis of L/H-Pgds-/-uteri, and immunohistochemistry and immunofluorescence analyses of proliferation (Ki67), endothelial cell (CD31), epithelial cell (pan-cytokeratin), myofibroblast (a-SMA) and mesenchymal cell (vimentin) markers, identify that 6-month-old L/H-Pgds-/-animals developed adenomyotic lesions, and that disease severity increased with age. In conclusion, this study suggests that the PGD2 pathway has major roles in the uterus by protecting the endometrium against adenomyosis development. Additional experiments, using for instance transcriptomic approaches, are necessary to fully determine the molecular mechanisms that lead to adenomyosis in L/H-Pgds-/- mice and to confirm whether this strain is an appropriate model for studying the human disease.

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“…Flurbiprofen axetil has a targeted analgesic effect for visceral pain. Hu et al 11 found out that the expression of F prostanoid receptors in postpartum myometrium was increased, the prostaglandin F2, oxytocin, acetylcholine-induced uterine contractions in rats. Nuray et al 12 pointed out that neutrophils, mast cells, and macrophages release in ammatory mediators like prostaglandins resulting in hyperalgesia in the injured and in amed tissues.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of intravenous flurbiprofen axetil with epidural analgesia for post-cesarean section analgesia: a multi-center, prospective, randomized, blinded trial

Zhang

et al. 2021

Preprint

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BackgroundEpidural analgesia provided satisfactory analgesic effects of incision pain after cesarean section. However, uterine contraction pain is also a common complication that cannot be relieved despite adequate levels of sensory blockade by epidural analgesia. This study evaluates the effect of flurbiprofen axetil with patient-controlled epidural analgesia on incision pain and uterine contraction pain after cesarean section.MethodsA multi-center, prospective, randomized, blinded trial was performed. 1000 obstetric patients scheduled for cesarean delivery were randomized to receive epidural analgesia with intravenous flurbiprofen axetil (group EF) or placebo (group E) postoperatively. The primary outcomes were incision pain and uterine contraction pain score 48 hours after a cesarean section. Secondary outcomes were the PCEA attempts, the incidence of complication, satisfaction scores, and return of gastrointestinal (GI) function.ResultsBaseline characteristics were similar between groups. The VAS of uterine contraction pain was significantly lower in group EF than in group E from 12 hours to 48 hours after cesarean delivery (P < 0.01). The VAS of incision pain at rest and on movement was lower in group EF than in group E from 12 hours to 48 hours after cesarean delivery. While sitting or walking, the VAS of incision pain was lower in group EF compared with that in group E. GI function recovered faster in group EF than that in group E (15 ± 6 vs. 25 ± 12, 95%CI 5.7 to 8.7, P < 0.01). The satisfaction scores are higher in group EF than that in group E (3.2 ± 0.5 vs. 2.9 ± 0.5, 95%CI -0.36 to -0.11, P < 0.01).ConclusionCombination flurbiprofen axetil with PCEA provides more effective analgesia for uterine contraction pain and incision pain after cesarean section, with a higher quality of recovery and better satisfaction scores.Trials RegistrationThis study was approved by the Institutional Review Board of Guangzhou Women and Children’s Medical Center (IRB2017062201) and written informed consent was obtained from his or her parents or legal guardians for each pediatric patient in the trial. The trial was registered before patient enrollment at chictr.org.cn (ChiCTR-IOR-17011956, Principal investigator: Ying-Jun She, Date of registration: 2017.07.12). Written informed consent was obtained from patients in the study.

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Prostaglandin D2 evokes potent uterine contraction via the F prostanoid receptor in postpartum rats

Cited by 8 publications

References 33 publications

Endothelium‐dependent contraction: The non‐classical action of endothelial prostacyclin, its underlying mechanisms, and implications

Endothelium‐dependent contraction: The non‐classical action of endothelial prostacyclin, its underlying mechanisms, and implications

In the mouse, prostaglandin D2 signalling protects the endometrium against adenomyosis

Efficacy of intravenous flurbiprofen axetil with epidural analgesia for post-cesarean section analgesia: a multi-center, prospective, randomized, blinded trial

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