Prostaglandin E₂ bei Prostatitis und Prostataadenom

Abstract

The measurement of prostaglandin E₂ (PGE₂) concentrations in the serum and prostatic fluid of healthy men, patients with prostatic hyperplasia and of patients with prostatitis was attempted and correlated to the state of disease, respectively. PGE₂-concentrations with prostatic fluid of healthy men were found to be significantly lower than in patients with prostatitis. Corresponding to the course of treatment concentrations normalized, being favorably influenced by sitosterin as an adjuvant medication. Compared to healthy men, PGE₂ concentrations in the prostatic fluid of patients with hyperplasia of the prostate incline to lower levels.

Common biological factors implicated in benign prostatic hyperplasia and prostate cancer, conventional and phytotherapeutic approaches employed in management: A review

“…It has been shown that the phytosterols, mainly β-sitosterol, possess anti-inflammatory activity and inhibit the stimulation and synthesis of prostaglandins, aromatase activity and 5α-reductase activity [131]. β-sitosterol reportedly helps in the reduction of high levels of prostaglandins in BPH patients [132] and suppresses prostatic growth factors and cholesterol accumulation. Phytosterols have also been reported to eliminate blood vessel congestion and excess blood and consequently, reduce the size of prostate adenomas.…”

Prostatitis versus pelvic pain syndrome: Immunologic studies

“…Some of the cytokines, which have been reported to occur in elevated levels in Category III patients, are known to exert hyperalgesic effects, including TNFα, IL-1β, IL-6, and IL-8 [75,76]. High IL-1β in Category III CPPS also may be responsible for the stimulation of nociceptors through induction of prostaglandin synthesis [77] because prostaglandin E2 levels in the EPS of patients with chronic prostatitis were elevated compared with control subjects [78]. The detection of low expression of IL-10 in some patients with Category III CPPS [33] could additionally result in reduced antinociceptive effects [79].…”

Nonbacterial Prostatitis: A Comprehensive Review

“…In non bacterial prostatitis the cultures are always negative in all four aliquots. Measurement of prostaglandin E2 con centration in prostatic fluid showed a significantly lower concentration in healthy men than in patients with pros tatitis [23], Prostatic biopsy unfortunately is not specifi cally diagnostic of (non)bacterial prostatitis [18]. Two studies, in which the patients had prostatic biopsies fol lowed by culturing for bacteria and for viruses, demon strated no etiologic role for such pathogens [24].…”