2011
DOI: 10.1124/jpet.111.189845
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Prostaglandin E2Promotes Wound-Induced Migration of Intestinal Subepithelial Myofibroblasts via EP2, EP3, and EP4 Prostanoid Receptor Activation

Abstract: Intestinal subepithelial myofibroblasts (ISMFs) are mesenchymal cells that reside in the subepithelial region throughout the intestine. When the intestine is damaged, the migratory and mitotic responses of ISMFs are crucial for wound closure. However, their mechanism of action remains unknown. We have investigated the role of cyclooxygenase (COX) and its metabolite prostaglandin E 2 (PGE 2 ) in the wound repair process of bovine ISMFs. The action of a mechanical scratch in a layer of ISMFs in cell culture elev… Show more

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Cited by 36 publications
(19 citation statements)
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“…Previous studies suggest that COX-2 can regulate myofibroblast migration in an autocrine fashion in both stimulated and unstimulated cells [3032], though enhanced myofibroblast migration has not been previously demonstrated following exposure to TNF-α. In patients with Crohn’s disease, the stromal compartment has been identified as the major reservoir of COX-2 derived by-products [3335].…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies suggest that COX-2 can regulate myofibroblast migration in an autocrine fashion in both stimulated and unstimulated cells [3032], though enhanced myofibroblast migration has not been previously demonstrated following exposure to TNF-α. In patients with Crohn’s disease, the stromal compartment has been identified as the major reservoir of COX-2 derived by-products [3335].…”
Section: Discussionmentioning
confidence: 99%
“…Although the inhibitory effects of PGE 2 on myofibroblasts are protective against excessive fibrotic scar formation in the lung and skin, PGE 2 may elicit distinct effects at other sites of tissue injury. For example, Iwanage et al [63] have recently shown that EP2/3/4 receptor signaling can induce the migration of intestinal sub-epithelial myofibroblasts (ISMFs) during wound closure. Moreover, PGE 2 is also capable of promoting the proliferation of cardiac fibroblasts via EP1/EP3 signaling [64], and inducing liver contraction via activation of the EP3 and FP receptors [65].…”
Section: Multifaceted Roles Of Pge2 In Inflammationmentioning
confidence: 99%
“…During the early inflammatory phase of tissue repair, immigrating macrophages and stromal cells produce PGE 2 , which has been shown to activate myofibroblasts and thus promote wound contraction (Figures and ). In addition, PGE 2 promoted wound closure in the skin by inducing the expression of the IL‐6 family cytokine oncostatin M in wound macrophages .…”
Section: Roles Of Eicosanoids In Tissue Repairmentioning
confidence: 99%