Prostaglandin E1 reduces myocardial reperfusion injury by inhibiting proinflammatory cytokines production during cardiac surgery

Kawamura, Takae; Nara, Noriko; Kadosaki, Mamoru; Inada, Katsuya; Endo, S

doi:10.1097/00003246-200007000-00004

Cited by 46 publications

(31 citation statements)

References 27 publications

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“…After histological analysis according Chiu et al 20 it was demonstrated that without PTX 1,13,14,16 and PGE1 [17][18][19][20] The PGE1 [17][18][19], is known by its intense vasodilator effect, for being a substance with intense biological activity that has been used for such a longtime to treat. the chronic arterial occlusive disease, since beside to vasodilation capacity it also inhibit platelets aggregation.…”

Section: Discussionmentioning

confidence: 99%

“…To minimize the ischemic effects on cells many types of drugs have been used during intestinal reperfusion as pentoxyflline 16 (PTX) and prostaglandin E1 (PGE1) 17 , in the ischemic-reperfusion process (I/R). PTX has antioxidant action inhibiting directly the anion superoxide, which indirectly blocks the action of the enzyme xanthine-oxidase.…”

Section: Introductionmentioning

confidence: 99%

“…PGE1 has a role in the activation of fibrinolysis and/ or fibrogenesis, in the modulation of cellular proliferation, in the hemorreologic activity of erithocytes, in the inhibition and activation of neutrophils capacities and also in the utilization of oxygen and glucose by the tissues. Beside to those effects there is evidence that PGE1 stimulates angiogenesis in cases of myocardic ischemia [17][18][19] .…”

Section: Introductionmentioning

confidence: 99%

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Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1

Brasileiro

Inoye²,

Aydos³

et al. 2013

Acta Cir. Bras.

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PURPOSE:To investigate the small intestinal tissue alterations in rats submitted to ischemia and tissue reperfusion using pentoxyfilline or prostaglandin E1. METHODS:Thirty five Wistar rats were used, distributed into group control (A) n=10 were submitted to intestinal ischemia and reperfusion during 60 minutes and no one drug have been utilized. In the group pentoxyfilline (B) n=10 have been utilized during tissue ischemia and reperfusion as well as prostaglandin E1 (C) n=10, but separately . In the group sham (D) n=5, the animals were submitted to surgical. After euthanasia of the animals, a segment of the small intestine was cut, stained by hematoxilin-eosin and histological analysis according to Chiu criteria. RESULTS:Histological results showed that using pentoxyflline or prostaglandin E1 the results during tissue reperfusion were better, since the levels of criteria from Chiu that predominated were level 2 and 3, indicating less tissue damage in comparison to the control group (group A) that showed levels 4 and 5, what means more severe histological tissue alterations. CONCLUSION:Use of pentoxyfilline or prostaglandin E1 promoted a beneficial effect during intestinal reperfusion, demonstrated by less severe histological lesions in the small intestine mucosa of rats submitted to ischemia and tissue reperfusion when helped by the drugs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1

Brasileiro

Inoye²,

Aydos³

et al. 2013

Acta Cir. Bras.

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“…The clinical manifestation of SIRS following CPB is mediated via cell-derived cytokines that target end-organ receptors. After CPB, elevated serum levels of the pro-inflammatory cytokines, tumor necrosis factor (TNF)-a, interleukin (IL)-6 and IL-8, as well as the anti-inflammatory cytokine IL-10 have been found 2,3 . The potent vasodilator nitric oxide (NO) has also been implicated in SIRS pathophysiology.…”

Section: Introductionmentioning

confidence: 99%

Effect of myocardial protection and perfusion temperature on production of cytokines and nitric oxide during cardiopulmonary bypass

et al. 2007

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Effect of myocardial protection and perfusion temperature on production of cytokines and nitric oxide during cardiopulmonary bypassEffect of myocardial protection and perfusion temperature on production of cytokines and nitric oxide during cardiopulmonary bypass ABSTRACT Purpose: To investigate the effects of different conditions used during cardiopulmonary bypass (CPB) surgery on accompanying production of cytokine and nitric oxide (NO). Methods: Patients undergoing CPB for the first time were prospectively enrolled and divided into two groups according to CPB parameters performed: i) normothermia (36.5-37°C) with blood cardioplegia (NB group, n=10) and ii) hypothermia (29-31°C) with crystalloid cardioplegia (HC group, n=10). Plasma samples obtained following intubation (baseline), during (5 and 30 min) and after (4 and 24 h) CPB were assayed for cytokines (ELISA) and NO metabolites (Griess reaction). Results: Peak concentrations of interleukin (IL)-6 and IL-8 were reached at 4 h post CPB in both groups, but in the HC group those levels increased earlier and persisted for longer (24 h) compared to baseline (P < 0.05). IL-10 levels also increased at 4 h compared to baseline, but only significantly so in the HC group. NO metabolites were reduced in HC group at all time points compared to baseline (P < 0.05), while no significant differences were detected in the NB group. Conclusion: The association between increased systemic levels of cytokines and reduced NO production in the HC group suggests that different myocardial protection and/or perfusion temperature used during CPB may contribute to the extent of inflammatory response. Key words: Cardiopulmonary Bypass. Myocardium. Perfusion. Nitric Oxide. Cytokines. RESUMOObjetivo: Investigar a hipótese de que diferentes procedimentos durante o bypass cardiopulmonary (BCP) causa diferentes níveis de citocinas (IL) e óxido nítrico (NO). Métodos: Pacientes submetidas a BCP foram prospectivamente estudadas de acordo com bypass realizado sobre normotermia (36.5-37°C) com cardioplegia sanguínea (NB group, n=10) or hipotermia (29-31°C) com cardioplegia cristalóide (HC group, n=10). Amostras de Plasma foram obtidas após a intubação (linha de base), durante (5, 30 min) e após (4, 24 h) o BCP. Os ensaios foram realizados através de ELISA (IL) e metabólitos do NO (reação de Griess). Resultados: Os picos de concentrações de IL-6 and IL-8 estavam aumentados em 4 h pós BCP em ambos os grupos, mas no grupo HC estes níveis aumentaram precocemente e persistiram aumentadas por 24 h, comparado a linha de base (P<0.05). O nível de IL-10 também teve o pico em 4 h, mas estatisticamente significante somente no grupo HC, comparado a linha de base. Os metabólitos do NO estavam reduzidos no grupo HC, em todo o tempo, comparado a linha de base (P<0.05), enquanto nenhuma diferença estatisticamente significante foi detectada no grupo NB. Conclusão: A associação entre o aumento sistêmico dos níveis de citocina e a redução da produção de NO no grupo HC sugere que o tipo de proteção miocárdica e/ou ...

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“…Kawamura et al (2000) reported that PGE1 reduced myocardial reperfusion injury by inhibiting proinflammatory cytokine productions, including IL-6 and IL-8, during cardiac surgery. Here we demonstrated that lipo-PGE1 suppressed the productions of serum IL-6 and TNF-α after myocardial infarction reperfusion.…”

Section: Fig 2 Excised Heart Stained With Evans Blue Dye and Thioflamentioning

confidence: 99%

Cardioprotective effect of liposomal prostaglandin E1 on a porcine model of myocardial infarction reperfusion no-reflow

Yang

et al. 2011

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To evaluate whether liposomal prostaglandin E1 (lipo-PGE1) can decrease reperfusion no-reflow in a catheter-based porcine model of acute myocardial infarction (AMI). Methods: Twenty-two male Chinese mini-swines were randomized into three groups: six in a sham-operation group, and eight each in the control and lipo-PGE1 groups. The distal part of the left anterior descending coronary artery (LAD) in the latter two groups was completely occluded for 2 h, and then reperfused for 3 h. Lipo-PGE1 (1 μg/kg) was injected 10 min before LAD occlusion until reperfusion for 1 h in the lipo-PGE1 group. Hemodynamic data and proinflammatory cytokines were examined before AMI, 2 h after occlusion, and 1, 2, and 3 h after reperfusion. Myocardial contrast echocardiography (MCE) and double staining were performed to evaluate the myocardial no-reflow area (NRA). Results: Left ventricular systolic pressure and end-diastolic pressure significantly improved in the lipo-PGE1 group after reperfusion compared with the control group and also 2 h after AMI (P<0.05 for both). MCE and double staining both showed that lipo-PGE1 decreased reperfusion NRA after AMI (P<0.05, P<0.01). Lipo-PGE1 decreased serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) after myocardial infarction reperfusion (P<0.05 for both). Conclusions: Lipo-PGE1 is cardioprotective in our porcine model of myocardial infarction reperfusion no-reflow, decreasing NRA and attenuating the inflammatory response.

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Prostaglandin E1 reduces myocardial reperfusion injury by inhibiting proinflammatory cytokines production during cardiac surgery

Abstract: PGE1 suppressed the production of IL-6 and IL-8 but not IL-10, IL-1ra, sTNF RI, or sTNF RII. The change in the balance between pro-and anti-inflammatory cytokines may be one of the most important cytoprotective mechanisms of PGE1.

Cited by 46 publications

References 27 publications

Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1

Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1

Effect of myocardial protection and perfusion temperature on production of cytokines and nitric oxide during cardiopulmonary bypass

Cardioprotective effect of liposomal prostaglandin E1 on a porcine model of myocardial infarction reperfusion no-reflow

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