Prostaglandin E2, 9S-, 13S-HODE and resolvin D1 are strongly associated with the post-stroke cognitive impairment

Kotlęga, Dariusz; Peda, Barbara; Drozd, Arleta; Zembroń-Łacny, Agnieszka; Stachowska, Ewa; Gramacki, J.

doi:10.1016/j.prostaglandins.2021.106576

Cited by 13 publications

(14 citation statements)

References 80 publications

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“…Kotlęga et al. ( 60 ) demonstrated that higher levels of RvD1 were associated with better cognitive functions in the acute phase of stroke and during the 6-month follow-up. In an experimental model of cerebral I/R injury, RvD1 could reduce oxidative stress, inflammatory response, and neuronal apoptosis, probably by inactivating NLRP3 (NOD-like receptor family pyrin domain containing 3) inflammasome ( 61 ).…”

Section: Discussionmentioning

confidence: 99%

“…Szczuko et al (59) reported that plasma RvD1 levels in patients with AIS were significantly lower in comparison to control subjects, and suggested that RvD1 is one of the most important PUFA derivatives in reducing post-stroke inflammation. Kotlęga et al (60) demonstrated that higher levels of RvD1 were associated with better cognitive functions in the acute phase of stroke and during the 6-month follow-up. In an experimental model of cerebral I/R injury, RvD1 could reduce oxidative stress, inflammatory response, and neuronal apoptosis, probably by inactivating NLRP3 (NOD-like receptor family pyrin domain containing 3) inflammasome (61).…”

Section: Discussionmentioning

confidence: 99%

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Plasma Lipid Mediators Associate With Clinical Outcome After Successful Endovascular Thrombectomy in Patients With Acute Ischemic Stroke

Hao

Feng

et al. 2022

Front. Immunol.

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BackgroundNeuroinflammatory response contributes to early neurological deterioration (END) and unfavorable long-term functional outcome in patients with acute ischemic stroke (AIS) who recanalized successfully by endovascular thrombectomy (EVT), but there are no reliable biomarkers for their accurate prediction. Here, we sought to determine the temporal plasma profiles of the bioactive lipid mediators lipoxin A4 (LXA4), resolvin D1 (RvD1), and leukotriene B4 (LTB4) for their associations with clinical outcome.MethodsWe quantified levels of LXA4, RvD1, and LTB4 in blood samples retrospectively and longitudinally collected from consecutive AIS patients who underwent complete angiographic recanalization by EVT at admission (pre-EVT) and 24 hrs post-EVT. The primary outcome was unfavorable long-term functional outcome, defined as a 90-day modified Rankin Scale score of 3-6. Secondary outcome was END, defined as an increase in National Institutes of Health Stroke Scale (NIHSS) score ≥4 points at 24 hrs post-EVT.ResultsEighty-one consecutive AIS patients and 20 healthy subjects were recruited for this study. Plasma levels of LXA4, RvD1, and LTB4 were significantly increased in post-EVT samples from AIS patients, as compared to those of healthy controls. END occurred in 17 (20.99%) patients, and 38 (46.91%) had unfavorable 90-day functional outcome. Multiple logistic regression analyses demonstrated that post-EVT levels of LXA4 (adjusted odd ratio [OR] 0.992, 95% confidence interval [CI] 0.987-0.998), ΔLXA4 (adjusted OR 0.995, 95% CI 0.991-0.999), LTB4 (adjusted OR 1.003, 95% CI 1.001-1.005), ΔLTB4 (adjusted OR 1.004, 95% CI 1.002-1.006), and post-EVT LXA4/LTB4 (adjusted OR 0.023, 95% CI 0.001-0.433) and RvD1/LTB4 (adjusted OR 0.196, 95% CI 0.057-0.682) ratios independently predicted END, and post-EVT LXA4 levels (adjusted OR 0.995, 95% CI 0.992-0.999), ΔLXA4 levels (adjusted OR 0.996, 95% CI 0.993-0.999), and post-EVT LXA4/LTB4 ratio (adjusted OR 0.285, 95% CI 0.096-0.845) independently predicted unfavorable 90-day functional outcome. These were validated using receiver operating characteristic curve analyses.ConclusionsPlasma lipid mediators measured 24 hrs post-EVT were independent predictors for early and long-term outcomes. Further studies are needed to determine their causal-effect relationship, and whether the imbalance between anti-inflammatory/pro-resolving and pro-inflammatory lipid mediators could be a potential adjunct therapeutic target.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Plasma Lipid Mediators Associate With Clinical Outcome After Successful Endovascular Thrombectomy in Patients With Acute Ischemic Stroke

Hao

Feng

et al. 2022

Front. Immunol.

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“…Further studies demonstrate how RvD2 and RvE1 supply may significantly decrease or slow down atherosclerotic changes as well [ 25 ]. Post-stroke blood levels of RvD1 have also been found to correlate with cognitive performance: in a prospective study assessing the impact of eicosanoids on cognitive function in stroke survivors, prostaglandin E2, 9S-, 13S-HODE and RvD1 were all strongly associated with the post-stroke cognitive impairment, while RvD1 only correlated with better cognitive performance [ 31 ].…”

Section: Specialized Pro-resolving Mediators and Potential Applicatio...mentioning

confidence: 99%

Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications

et al. 2022

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Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-unsaturated fatty acids (PUFAs) which have been demonstrated to have an important role in the inflammation environment, preventing an overreaction of the organism and promoting the resolution of inflammation. Our purpose was to point out the current evidence for specialized pro-resolving mediators, focusing on their role in neuroinflammation and in major neurological diseases.

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“…Demir et al (2020) made the conclusion that DHAP (18:0), PGD2/I2, porphobilinogen, 5methyltetrahydrofolic acid, and N-Acetyl-4-O-acetylneuraminic acid/N-Acetyl-7-O-acetylneuraminic acid may serve as biomarkers for predicting HSP with kidney disease through an untargeted metabolomics approach in serum. 9S-and 13S-HODEs, oxidized linoleic acid metabolites and derived from linoleic acid, can reflect the status of oxidative stress and are linked to inflammation, atherogenesis, metabolic syndrome, and stroke (Vangaveti et al, 2016;Kotlega et al, 2021). 9S/13S HODE were declined in a study of stroke, and at last, indicating the most important inflammatory derivatives of free fatty acids related to cognitive decline after stroke (Kotlega et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…9S-and 13S-HODEs, oxidized linoleic acid metabolites and derived from linoleic acid, can reflect the status of oxidative stress and are linked to inflammation, atherogenesis, metabolic syndrome, and stroke (Vangaveti et al, 2016;Kotlega et al, 2021). 9S/13S HODE were declined in a study of stroke, and at last, indicating the most important inflammatory derivatives of free fatty acids related to cognitive decline after stroke (Kotlega et al, 2021). Therefore, it is speculated that the AA metabolites may be related to the pathogenesis of HSP by the COX pathway and LOX pathway.…”

Section: Discussionmentioning

confidence: 99%

Integrated Analyses of Gut Microbiome and Host Metabolome in Children With Henoch-Schönlein Purpura

Wen

Dang

Feng

et al. 2022

Front. Cell. Infect. Microbiol.

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Recent studies have shown that intestinal microbes and metabolites are involved in the pathogenesis of many diseases. However, whether and how they are related to Henoch–Schönlein purpura (HSP) has yet to be understood. This work is designed to detect gut microbes, intestinal and serum metabolites in children with HSP, trying to discover the etiology and pathogenesis of HSP. A total of 86 children were recruited in this study, namely, 58 children with HSP (HSP group) and 28 healthy children as control groups (CON group). 16S rDNA amplicon sequencing technology and UPLC-QTOF/MS non-targeted metabolomics analysis were used to detect the intestinal microbes and metabolites, and also multi-reaction monitoring technology for detecting serum arachidonic acid (AA) and its metabolites. Then, correlation analysis was performed to explore the possible interaction between the differential gut microbes and metabolites. As a result, at the microbiota family level, the CON group had an advantage of Coriobacteriaceae while the HSP group had a dominant Bacteroidaceae. Five kinds of bacteria in the HSP group were significantly enriched at the genus level, and seven kinds of bacteria were significantly enriched in the CON group. A total of 59 kinds of gut metabolites significantly differ between the two groups, in which most are lipids and peptides. Spearman correlation analysis showed that Bacteroides, Dialister, and Agathobacter were associated with unsaturated fatty acids, especially AA metabolism. Then, we tested the AA related metabolites in serum and found thromboxane B2, leukotriene B4, prostaglandin D2, 9S-hydroxyoctadecadienoic acid, and 13S-hydroxyoctadecadienoic acid significantly changed. In conclusion, children with HSP had dominant Bacteroidaceae and decreased Coriobacteriaceae in the family level of gut microbes, and also lipids and peptides changed most in the gut metabolites. Our data suggested that the biosynthesis and metabolism of unsaturated fatty acids, especially AA and its metabolites, might participate in the occurrence and development of HSP.

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Prostaglandin E2, 9S-, 13S-HODE and resolvin D1 are strongly associated with the post-stroke cognitive impairment

Cited by 13 publications

References 80 publications

Plasma Lipid Mediators Associate With Clinical Outcome After Successful Endovascular Thrombectomy in Patients With Acute Ischemic Stroke

Plasma Lipid Mediators Associate With Clinical Outcome After Successful Endovascular Thrombectomy in Patients With Acute Ischemic Stroke

Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications

Integrated Analyses of Gut Microbiome and Host Metabolome in Children With Henoch-Schönlein Purpura

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