Prostaglandin E2, prostacyclin, and thromboxane changes during nonpulsatile cardiopulmonary bypass in humans

Faymonville, Marie-Élisabeth; Deby‐Dupont, G.; Larbuisson, Robert; Deby, C.; Bodson, Lucien; Limet, Raymond; Lamy, Maurice

doi:10.1016/s0022-5223(19)35964-1

Cited by 99 publications

(8 citation statements)

References 21 publications

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“…Preoperative elevations in PVR has been considered an important risk factor for patients who undergo open heart surgery. [1][2][3][4][5][6][7][8][9][17][18][19][20][21][22][23][24][25] In particular, it was demonstrated that CPB institution may produce significative changes in vascular endothelium when normal blood supply via pulmonary artery is removed. Ischemic damage to pulmonary vascular endothelium produces a defect in vasoactive substances release, production, and/or intracellular signal transduction.…”

Section: Variablesmentioning

confidence: 99%

“…Nitroprusside, amrinone, prostaglandin E1 (prostacyclin), and inhaled nitric oxide were recently used to evaluate potential reversibility of pulmonary hypertension in candidates for heart transplantation. [20][21][22][23][24][25] In our series the institution of CPB produced marked changes in PVR and mean PAP. Prostacyclin infusion reversed significantly postoperative pulmonary hypertension with a statistical significant improvement in CI.…”

Section: Variablesmentioning

confidence: 99%

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Inhaled Prostacyclin, Nitric Oxide, and Nitroprusside in Pulmonary Hypertension After Mitral Valve Replacement

Fattouch

Sbraga

Bianco

et al. 2005

Journal of Cardiac Surgery

118

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Inhaled prostacyclin and nitric oxide are effective in the treatment of postoperative pulmonary hypertension in patients with mitral valve stenosis undergoing mitral valve surgery. Both drugs improve cardiac output and reduce mean pulmonary arterial pressure, pulmonary vascular resistance, and trans-pulmonary gradient. They may be useful in patients with acute right ventricular failure following cardiac surgery. In comparison to nitric oxide, inhaled prostacyclin is free from toxic side effects and is easier to administer.

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Section: Variablesmentioning

confidence: 99%

Section: Variablesmentioning

confidence: 99%

Inhaled Prostacyclin, Nitric Oxide, and Nitroprusside in Pulmonary Hypertension After Mitral Valve Replacement

Fattouch

Sbraga

Bianco

et al. 2005

Journal of Cardiac Surgery

118

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“…The aetiology of graft vasospasm is likely to be multifactorial, including trauma at the time of surgery, endothelial disruption and the presence of vasoactive substances. Endothelin-1 (ET-1) and thromboxane A 2 (TXA 2 ) are two of the most potent endogenous vasoconstrictors , circulating levels of which have been shown to rise at the time of surgery (Watkins et al, 1982;Faymonville et al, 1986). ET-1 is released by the endothelium, whereas the prostanoid TXA 2 is released from platelets.…”

Section: Introductionmentioning

confidence: 99%

Rho‐kinase inhibitors prevent agonist‐induced vasospasm in human internal mammary artery

Batchelor

Sádaba

Ishola

et al. 2001

British J Pharmacology

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1 Vasospasm of arterial conduits used for coronary artery surgery is an important cause of graft failure and is likely to result partly from raised levels of vasoconstrictor substances such as thromboxane A 2 and endothelin-1. Our aim was to ®nd pharmacological agents that could prevent agonist-induced vasospasm. 2 Isometric tension was recorded from discarded segments of human left internal mammary artery (LIMA). Submaximal contraction evoked by the thromboxane A 2 mimetic U46619 (10 nM) was not inhibited by a blocker of store-and receptor-operated Ca 2+ channels (30 mM SKF96365) in the presence of diltiazem. Furthermore, contractions to 41 nM U46619 were preserved when extracellular Ca 2+ was reduced from 2.5 mM to 60 nM. Thus, sustained U46619-evoked contraction occurred without Ca 2+ in¯ux. 3 We hypothesized that contraction might occur via Rho-kinase-mediated Ca 2+ -sensitization of myo®laments. Inhibitors of Rho-kinase (Y27632 and HA1077) were profound relaxants. If contraction was pre-evoked by 10 nM U46619, Y27632 and HA1077 caused full relaxation with EC 50 s of 1.67+0.22 mM and 3.58+0.35 mM respectively. Y27632 was also eective if applied before U46619, but was less potent. 4 Y27632 abolished contraction evoked by endothelin-1 and signi®cantly reduced resting tone in the absence of a vasoconstrictor. 5 Rho-kinase-mediated Ca 2+ -sensitization appears to be a major mechanism of vasoconstriction in human LIMA. Rho-kinase inhibitors may have an important role in preventing vasospasm in arterial grafts used for coronary artery surgery.

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“…They concluded that this imbalance may help cause a continuous elevation in PVR 46 . Studies have also demonstrated that this very imbalance is associated with CPB 47–52 …”

Section: Resultsmentioning

confidence: 98%

Pulmonary hypertension associated with cardiopulmonary bypass and cardiac surgery

Fayad

Sellke

Feng

2022

Journal of Cardiac Surgery

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Background and Aim Pulmonary hypertension (PH) is frequently associated with cardiovascular surgery and is a common complication that has been observed after surgery utilizing cardiopulmonary bypass (CPB). The purpose of this review is to explain the characteristics of PH, the mechanisms of PH induced by cardiac surgery and CPB, treatments for postoperative PH, and future directions in treating PH induced by cardiac surgery and CPB using up‐to‐date findings. Methods The PubMed database was utilized to find published articles. Results There are many mechanisms that contribute to PH after cardiac surgery and CPB which involve pulmonary vasomotor dysfunction, cyclooxygenase, the thromboxane A2 and prostacyclin pathway, the nitric oxide pathway, inflammation, and oxidative stress. Furthermore, there are several effective treatments for postoperative PH within different types of cardiac surgery. Conclusions By possessing a deep understanding of the mechanisms that contribute to PH after cardiac surgery and CPB, researchers can develop treatments for clinicians to use which target the mechanisms of PH and ultimately reduce and/or eliminate postoperative PH. Additionally, learning about the most up‐to‐date studies regarding treatments can allow clinicians to choose the best treatments for patients who are undergoing cardiac surgery and CPB.

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Prostaglandin E2, prostacyclin, and thromboxane changes during nonpulsatile cardiopulmonary bypass in humans

Cited by 99 publications

References 21 publications

Inhaled Prostacyclin, Nitric Oxide, and Nitroprusside in Pulmonary Hypertension After Mitral Valve Replacement

Inhaled Prostacyclin, Nitric Oxide, and Nitroprusside in Pulmonary Hypertension After Mitral Valve Replacement

Rho‐kinase inhibitors prevent agonist‐induced vasospasm in human internal mammary artery

Pulmonary hypertension associated with cardiopulmonary bypass and cardiac surgery

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