Prostaglandin in teh uterus: Modulation by steroid hormones

Pakrasi, Pranab L.; Cheng, Haiyung; Dey, Sudhansu K.

doi:10.1016/0090-6980(83)90160-0

Cited by 65 publications

(20 citation statements)

References 31 publications

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“…Thus both oestradiol (Pakrasi et al 1983, Nakayama et al 1991 and progesterone (Franchi et al 1982) administration to ovariectomized rats increased uterine PGF 2 output. However, when administered together in rats progesterone was able to prevent the increase in PGF 2 secretion induced by oestradiol (Kuehl et al 1975, Pakrasi et al 1983. In these studies it was, however, difficult to distinguish between endometrial and myometrial prostanoid production.…”

Section: Introductionmentioning

confidence: 99%

The regulation by ovarian steroids of prostaglandin synthesis and prostaglandin-induced contractility in non-pregnant rat myometrium. Modulating effects of isoproterenol

Engstrøm

2001

Journal of Endocrinology

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The objectives of the present study were to investigate the effects of the reproductive steroids oestradiol and progesterone on myometrial levels of cyclooxygenase-2 (COX-2) mRNA and PGF 2 induced myometrial contractility and to study whether the effect of 2 -adrenoceptor stimulation by isoproterenol on the myometrium alters these parameters.Oestrogen treatment of ovariectomized rats increased myometrial COX-2 mRNA whereas PGF 2 receptor (PGF 2 -R) mRNA was unchanged following this treatment and maximal contractility (E max ) of isolated uterine strips challenged with PGF 2 was unaltered. Progesterone treatment alone decreased COX-2 mRNA in comparison with values obtained from oestrogentreated animals, and in combination with oestrogen the enhancing effect of progesterone on COX-2 mRNA was curbed. EC 50 of uterine strips challenged with PGF 2 increased following oestrogen treatment whereas this parameter was substantially decreased following progesterone treatment.When oestrogen was combined with isoproterenol infusion mRNA values of both COX-2 and PGF 2 -R were reduced. Finally, when isoproterenol infusions were given in combination with both oestrogen and progesterone, PGF 2 -R mRNA and E max were enhanced as compared with similar rats not having received isoproterenol.We conclude that oestrogen increases COX-2 mRNA production and subsequent prostaglandin synthesis in nonpregnant rat myometrium. We further conclude that in the oestrogen-dominated rat myometrium the relaxing effect of 2 -adrenoceptor stimulation involves attenuation of both prostaglandin synthesis and PGF 2 -R expression. We finally conclude that in the presence of both oestrogen and progesterone this effect of 2 -adrenoceptor stimulation is restrained.

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Section: Introductionmentioning

confidence: 99%

The regulation by ovarian steroids of prostaglandin synthesis and prostaglandin-induced contractility in non-pregnant rat myometrium. Modulating effects of isoproterenol

Engstrøm

2001

Journal of Endocrinology

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“…COX is present in the rodent uterus and embryo, and synthesizes PGs during early pregnancy (Pakrasi & Dey 1983, Malathy et al 1986, Parr et aï. 1988 (Das et al 1995).…”

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confidence: 99%

Developmental expression of the cyclo-oxygenase-1 and cyclo-oxygenase-2 genes in the peri-implantation mouse uterus and their differential regulation by the blastocyst and ovarian steroids

Chakraborty¹,

Das²,

Wang³

et al. 1996

Journal of Molecular Endocrinology

314

179

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“…First, PLA2 activity and hence the production of prostaglandins in membranes, decidua and myometrium seem to be under close estrogen and progesterone control. Indeed, experimental studies in rats have shown that progesterone inhibits PLA2 activity in vivo whereas estrogen has the opposite effect [97,98]. In rabbits, uteroglobin-PLA2 interaction probably mediates progesterone inhibition [99,100].…”

Section: Production Of Free Arachidonic Acid and Prostaglandinsmentioning

confidence: 99%

Fetal-Placental and Decidual-Placental Units: Role of Endocrine and Paracrine Regulations in Parturition

Carbillon

Uzan²,

Challier³

et al. 2000

Fetal Diagn Ther

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In primates, fetal adrenal and placental steroidogenic enzymatic systems are complementary in a fetal-placental unit, synchronizing fetal maturation and myometrial activation in late gestation. Moreover, as hemochorial placentation characterizes rodents and primates, paracrine regulations between decidua and placenta are essential to the immunotolerance of the conceptus and its development. Thus, the decidual-placental unit remains in a striking state of decidual quiescence throughout gestation, and the reversal of this quiescence is thought to play a key role in myometrial stimulation and the onset of parturition. A comprehensive view of the control of myometrial contractility, through the interaction of paracrine and endocrine modifications in late gestation, is proposed. The failure of these mechanisms underlie prematurity and the use of fetal therapy in threatened preterm labor.

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Prostaglandin in teh uterus: Modulation by steroid hormones

Cited by 65 publications

References 31 publications

The regulation by ovarian steroids of prostaglandin synthesis and prostaglandin-induced contractility in non-pregnant rat myometrium. Modulating effects of isoproterenol

The regulation by ovarian steroids of prostaglandin synthesis and prostaglandin-induced contractility in non-pregnant rat myometrium. Modulating effects of isoproterenol

Developmental expression of the cyclo-oxygenase-1 and cyclo-oxygenase-2 genes in the peri-implantation mouse uterus and their differential regulation by the blastocyst and ovarian steroids

Fetal-Placental and Decidual-Placental Units: Role of Endocrine and Paracrine Regulations in Parturition

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