Prostaglandin-Induced Cystoid Macular Edema Following Routine Cataract Extraction

Agange, Negin; Mosaed, Sameh

doi:10.1155/2010/690707

Cited by 22 publications

(17 citation statements)

References 12 publications

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“…Cystoid macular edema (CME) has been reported in association with the use of latanoprost, travoprost, and bimatoprost 1,2. These drugs are ocular hypotensive lipids, and their side effects can be expected to be somewhat similar.…”

Section: Introductionmentioning

confidence: 99%

Subtenon triamcinolone injection for postoperative cystoid macular edema associated with tafluprost

Matsuura¹,

Uotani²,

Terasaka³

2013

OPTH

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PurposeWe report the successful treatment of a case of cystoid macular edema (CME) associated with topical tafluprost, which was accompanied by serous retinal detachment (SRD).CaseA 78-year-old woman underwent intraocular lens suture surgery, including anterior vitreous cutting, for crystalline lens dislocation in the right eye. Tafluprost was initiated 12 weeks after surgery. Intraocular pressure (IOP) was controlled at 10–14 mmHg. Visual acuity remained at 20/40–30/40. However, the patient complained of blurred vision (20/200) 9 months after surgery. CME accompanied by SRD was identified by optical coherence tomography (OCT) and treated with subtenon triamcinolone injection. Visual acuity rapidly increased to 20/50, and the volume of SRD decreased in a few days. Discontinuation of tafluprost and initiation of diclofenac eye drops improved visual acuity to 20/40 and resulted in improved OCT findings within a few weeks. Three months after injection, tafluprost was resumed along with diclofenac. No recurrence of CME occurred over the following 3 months, and IOP was controlled at 10–15 mmHg.ConclusionSRD is considered to be a symptom of treatment-resistant CME, which may lead to poor visual acuity after recovery. In such cases, subtenon triamcinolone injection should be strongly considered at an early stage.

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Section: Introductionmentioning

confidence: 99%

Subtenon triamcinolone injection for postoperative cystoid macular edema associated with tafluprost

Matsuura¹,

Uotani²,

Terasaka³

2013

OPTH

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“…33 Cystoid macular oedema is the result of chronic oedema that persists for ≥ 4 months, leading to the formation of cystic honeycomb-like spaces in the retina, 34 and can occur as a consequence of retinal dystrophies, 35 inflammatory diseases (uveitis, scleritis, birdshot chorioretinopathy, toxoplasmosis), 36 retinal vascular disease (retinal vein occlusions, idiopathic retinal telangiectasia, radiation retinopathy), 34 diabetic retinopathy, 34 cataract or other eye surgery, injury to the eye, choroidal tumours, or may be drug induced, for example with prostaglandins such as latanoprost. 37 As with other macular conditions, the main symptoms of cystoid macular oedema are blurred or decreased central vision, but peripheral vision is unaffected. Estimates of the incidence and prevalence of cystoid macular oedema vary considerably depending on the cause of the oedema.…”

Section: Cystoid Macular Oedemamentioning

confidence: 99%

Accuracy of fundus autofluorescence imaging for the diagnosis and monitoring of retinal conditions: a systematic review

Frampton

Kalita

Payne

et al. 2016

Health Technol Assess

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BackgroundNatural fluorescence in the eye may be increased or decreased by diseases that affect the retina. Imaging methods based on confocal scanning laser ophthalmoscopy (cSLO) can detect this ‘fundus autofluorescence’ (FAF) by illuminating the retina using a specific light ‘excitation wavelength’. FAF imaging could assist the diagnosis or monitoring of retinal conditions. However, the accuracy of the method for diagnosis or monitoring is unclear.ObjectiveTo conduct a systematic review to determine the accuracy of FAF imaging using cSLO for the diagnosis or monitoring of retinal conditions, including monitoring of response to therapy.Data sourcesElectronic bibliographic databases; scrutiny of reference lists of included studies and relevant systematic reviews; and searches of internet pages of relevant organisations, meetings and trial registries. Databases included MEDLINE, EMBASE, The Cochrane Library, Web of Science and the Medion database of diagnostic accuracy studies. Searches covered 1990 to November 2014 and were limited to the English language.Review methodsReferences were screened for relevance using prespecified inclusion criteria to capture a broad range of retinal conditions. Two reviewers assessed titles and abstracts independently. Full-text versions of relevant records were retrieved and screened by one reviewer and checked by a second. Data were extracted and critically appraised using the Quality Assessment of Diagnostic Accuracy Studies criteria (QUADAS) for assessing risk of bias in test accuracy studies by one reviewer and checked by a second. At all stages any reviewer disagreement was resolved through discussion or arbitration by a third reviewer.ResultsEight primary research studies have investigated the diagnostic accuracy of FAF imaging in retinal conditions: choroidal neovascularisation (one study), reticular pseudodrusen (three studies), cystoid macular oedema (two studies) and diabetic macular oedema (two studies). Sensitivity of FAF imaging using an excitation wavelength of 488 nm was generally high (range 81–100%), but was lower (55% and 32%) in two studies using longer excitation wavelengths (514 nm and 790 nm, respectively). Specificity ranged from 34% to 100%. However, owing to limitations of the data, none of the studies provide conclusive evidence of the diagnostic accuracy of FAF imaging.LimitationsNo studies on the accuracy of FAF imaging for monitoring the progression of retinal conditions or response to therapy were identified. Owing to study heterogeneity, pooling of diagnostic outcomes in meta-analysis was not conducted. All included studies had high risk of bias. In most studies the patient spectrum was not reflective of those who would present in clinical practice and no studies adequately reported how FAF images were interpreted.ConclusionsAlthough already in use in clinical practice, it is unclear whether or not FAF imaging is accurate, and whether or not it is applied and interpreted consistently for the diagnosis and/or monitoring of retinal conditions. Well-designed prospective primary research studies, which conform to the paradigm of diagnostic test accuracy assessment, are required to investigate the accuracy of FAF imaging in diagnosis and monitoring of inherited retinal dystrophies, early age-related macular degeneration, geographic atrophy and central serous chorioretinopathy.Study registrationThis study is registered as PROSPERO CRD42014014997.FundingThe National Institute for Health Research Health Technology Assessment programme.

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“…Of note, endogenous prostaglandins are proinflammatory in nature. They are the key risk factors responsible for CME in patients following cataract surgeries [6]. There are various clinical case reports about the side effect of synthetic prostaglandin analogues (such as latanoprost and travaprost) suggesting a causative link between PGAs and CME in patients, who have undergone both uneventful cataract surgeries and routine cataract extraction [6,7].…”

Section: Rescula (B-k Channel Activator) Vs Prostaglandinmentioning

confidence: 99%

“…They are the key risk factors responsible for CME in patients following cataract surgeries [6]. There are various clinical case reports about the side effect of synthetic prostaglandin analogues (such as latanoprost and travaprost) suggesting a causative link between PGAs and CME in patients, who have undergone both uneventful cataract surgeries and routine cataract extraction [6,7]. A recent 6-month head-to-head randomized clinical study comparing three different PGAs vs rescula in patients with POAG or OH has strengthened the argument that PGAs pose a potential risk of CME due to the breakdown of bloodaqueous barrier in patients treated with travoprost, bimatoprost, and latanoprost (but not Rescula) [8].…”

Section: Rescula (B-k Channel Activator) Vs Prostaglandinmentioning

confidence: 99%

“…Endogenous prostaglandins are known to modulate normal cell function and participate in broad intricate inflammatory processes such as CME and uveitis [5,6]. As a B-K channel activator, the potential benefits of anti-inflammatory and neuroprotective functions may open up a broad therapeutic niche window to those whose glaucoma pathological identities involve with a complex chronic ocular inflammatory process, such as refractory glaucoma, or a combination of glaucoma with other ocular inflammatory conditions (uveitis).…”

Section: Conclusion and Future Prospectmentioning

confidence: 99%

See 1 more Smart Citation

Revisit Rescula and Cystoid Macular Edema and Refractory Glaucoma

Qiu¹,

Craven²

2015

J Clin Exp Ophthalmol

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Rescula (unoprostone isopropyl) has been in the market as ocular hypotensive drug since 1994. There are amounting scientific research and post-marketing clinical experiences reported in peer review journals. Yet there seems limited understanding about its unique clinical implication associated with newly discovered molecular mechanism (traits) of BK channel activation. Hence this review article is using a focal lens with an eye on B-K channel activation to further delineate possible roles of rescula in modulating chronic parainflammation in the eye, which may eventually set it apart from the rest lipid hypotensive drugs such as latanoprost that is pro-inflammatory in nature. Cystoid macular edema and refractory glaucoma will be the key historical clinical case highlights.

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Prostaglandin-Induced Cystoid Macular Edema Following Routine Cataract Extraction

Cited by 22 publications

References 12 publications

Subtenon triamcinolone injection for postoperative cystoid macular edema associated with tafluprost

Subtenon triamcinolone injection for postoperative cystoid macular edema associated with tafluprost

Accuracy of fundus autofluorescence imaging for the diagnosis and monitoring of retinal conditions: a systematic review

Revisit Rescula and Cystoid Macular Edema and Refractory Glaucoma

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