“…In 1994, a case series described 5 infants being treated for congenital ductal-dependent heart disease who developed periostitis with the earliest onset being 14 days after prostaglandin infusion [14] . In more recent years, similar cases have been documented in 2017 and 2022 [15 , 16] . Among reported cases of vaccine related periostitis, patients displayed symptoms within a week of vaccine exposure.…”