Prostaglandins and bone metabolism

Choudhary, Shilpa; Pilbeam, Carol C.

doi:10.1016/b978-0-12-814841-9.00051-8

Cited by 23 publications

(1 citation statement)

References 578 publications

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“…Furthermore, as components of cell membranes, they can influence the fluidity and the behaviour of ECM components; membrane-bound enzymes and receptors or ion channels, affecting cellular signaling; the responsiveness to exogenous molecules; and the transport of proteins and minerals such as calcium (ion or mineral) [6,10]. In addition, they can impact bone formation directly or indirectly through their conversion into lipid mediators such as docosanoids and eicosanoids [11][12][13][14], which also present pro-or anti-osteogenic functions during skeletal formation (see reviews [12,13,15]). These nutrients and their mediators are also involved in key cellular processes such as calcium metabolism, oxidative stress, and inflammation that ultimately affect bone health [16].…”

Section: Introductionmentioning

confidence: 99%

Exploring Omega-3′s Impact on the Expression of Bone-Related Genes in Meagre (Argyrosomus regius)

Luján-Amoraga,

Delgado-Martín,

Lourenço-Marques

et al. 2023

Biomolecules

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Dietary supplementation with Omega-3 fatty acids seems to promote skeletal health. Therefore, their consumption at imbalanced or excessive levels has offered less beneficial or even prejudicial effects. Fish produced in aquaculture regimes are prone to develop abnormal skeletons. Although larval cultures are usually fed with diets supplemented with Omega-3 Long Chain Polyunsaturated fatty acids (LC-PUFAs), the lack of knowledge about the optimal requirements for fatty acids or about their impact on mechanisms that regulate skeletal development has impeded the design of diets that could improve bone formation during larval stages when the majority of skeletal anomalies appear. In this study, Argyrosomus regius larvae were fed different levels of Omega-3s (2.6% and 3.6% DW on diet) compared to a commercial diet. At 28 days after hatching (DAH), their transcriptomes were analyzed to study the modulation exerted in gene expression dynamics during larval development and identify impacted genes that can contribute to skeletal formation. Mainly, both levels of supplementation modulated bone-cell proliferation, the synthesis of bone components such as the extracellular matrix, and molecules involved in the interaction and signaling between bone components or in important cellular processes. The 2.6% level impacted several genes related to cartilage development, denoting a special impact on endochondral ossification, delaying this process. However, the 3.6% level seemed to accelerate this process by enhancing skeletal development. These results offered important insights into the impact of dietary Omega-3 LC-PUFAs on genes involved in the main molecular mechanism and cellular processes involved in skeletal development.

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Section: Introductionmentioning

confidence: 99%

Exploring Omega-3′s Impact on the Expression of Bone-Related Genes in Meagre (Argyrosomus regius)

Luján-Amoraga,

Delgado-Martín,

Lourenço-Marques

et al. 2023

Biomolecules

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Bone resorbing activity released from zymosan-activated mouse peritoneal macrophages - the role of prostanoids and interleukin-1

1999

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Prostaglandin E 2 (PGE 2 ) Autoamplifies its Production Through EP 1 Subtype of PGE Receptor in Mouse Osteoblastic MC3T3-E1 Cells

Suda

Tanaka

Yasoda

et al. 1998

Calcified Tissue International

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Prostaglandin E2 (PGE2) is known to autoamplify its production in the osteoblasts through the induction of prostaglandin G/H synthase-2 (PGHS-2), which is the inducible form of the rate-limiting enzyme in PG synthesis, PGHS. To elucidate the cellular mechanism mediating this process, we have employed the PGE2 analogs, which are specific agonists for four subtypes of PGE receptor, and studied the potency of these analogs to induce PGHS-2 mRNA in mouse osteoblastic MC3T3-E1 cells. The induction was mainly observed by 17-phenyl-omega-trinor PGE2 (EP1 agonist) and sulprostone (EP3/EP1 agonist), but not by butaprost (EP2 agonist) or 11-deoxy PGE1 (EP4/EP2 agonist). Since EP3 subtype was undetectable in MC3T3-E1 cells, these data indicate that PGHS-2 mRNA induction is mediated through EP1 subtype of PGE receptor in MC3T3-E1 cells. PGE2 production determined by radioimmunoassay was also increased by 17-phenyl-omega-trinor PGE2 and sulprostone. The autoamplification of PGE2 production is considered to be important in elongating the otherwise short-lived PGE2 action in certain physiological conditions such as mechanical stress and fracture healing, as well as the pathological inflammatory bone loss. The observations in the present study provide us with the better understanding of these processes.

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Prostaglandins and bone metabolism

Cited by 23 publications

References 578 publications

Exploring Omega-3′s Impact on the Expression of Bone-Related Genes in Meagre (Argyrosomus regius)

Exploring Omega-3′s Impact on the Expression of Bone-Related Genes in Meagre (Argyrosomus regius)

Bone resorbing activity released from zymosan-activated mouse peritoneal macrophages - the role of prostanoids and interleukin-1

Prostaglandin E 2 (PGE 2 ) Autoamplifies its Production Through EP 1 Subtype of PGE Receptor in Mouse Osteoblastic MC3T3-E1 Cells

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