Prostaglandins and consecutive vascular segments of the canine hindlimb

Ra, Greenberg; Sparks, Harvey V.

doi:10.1152/ajplegacy.1969.216.3.567

Cited by 47 publications

(20 citation statements)

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“…A number of previous studies have demonstrated the contractile effect of PGF2a both in cerebral (Toda, 1976;Edvinsson, Hardebo, McCulloch & Owman, 1978;Uski, Edvinsson & Owman, 1981) and peripheral vessels (Nakano, 1968;Greenberg & Sparks, 1969). The maximum contractile effect of PGF2.…”

Section: Discussionmentioning

confidence: 94%

Influence of extracellular calcium and calcium antagonists on contractions induced by potassium and prostaglandin F_2α in isolated cerebral and mesenteric arteries of the cat

Andersson

Edvinsson

MacKenzie

et al. 1983

British J Pharmacology

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1The effects of a number of calcium antagonists (diltiazem, nifedipine, nimodipine and verapamil) have been studied on feline isolated pial arteries contracted by potassium (127 mM) or prostaglandin F2X (PGF2,,, 2.5 riM) and mesenteric arteries contracted by potassium (127 mM). 2 Withdrawal of Ca2+ from the extracellular medium for 30 min reduced the contractile response to potassium in cerebral vessels by 92% and in mesenteric vessels by 96%. Subsequent addition of Ca2+ caused reproducible contractions which were inhibited by both nifedipine and nimodipine. 3 The four calcium antagonists relaxed the isolated middle cerebral artery contracted either by potassium or PGF2,,, and mesenteric arteries contracted by potassium, in the following order of potency: nimodipine > nifedipine > verapamil > diltiazem. 4 Nimodipine was more potent than nifedipine in cerebral arteries, and more potent in cerebral than in mesenteric arteries. Otherwise, the potassium-contracted cerebral and mesenteric vessels showed no major differences in sensitivity to calcium antagonists.

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Section: Discussionmentioning

confidence: 94%

Influence of extracellular calcium and calcium antagonists on contractions induced by potassium and prostaglandin F_2α in isolated cerebral and mesenteric arteries of the cat

Andersson

Edvinsson

MacKenzie

et al. 1983

British J Pharmacology

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“…PGE1 has been reported to relax the contraction of vascular smooth muscle cells [61] and increase blood flow in peripheral arteries [62] , followed by improvement of endothelial function [63] . Since PGE1 is rapidly inactivated in the lungs, PGE1 must be administered into the obstructed artery or a large amount of it has to be given intravenously.…”

Section: Effect Of Prostaglandin-e1 To Normal Nerve Root and Compressmentioning

confidence: 99%

Pathophysiology, diagnosis and treatment of intermittent claudication in patients with lumbar canal stenosis

Kobayashi

2014

WJO

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Spinal nerve roots have a peculiar structure, different from the arrangements in the peripheral nerve. The nerve roots are devoid of lymphatic vessels but are immersed in the cerebrospinal fluid (CSF) within the subarachnoid space. The blood supply of nerve roots depends on the blood flow from both peripheral direction (ascending) and the spinal cord direction (descending). There is no hypovascular region in the nerve root, although there exists a so-called water-shed of the bloodstream in the radicular artery itself. Increased mechanical compression promotes the disturbance of CSF flow, circulatory disturbance starting from the venous congestion and intraradicular edema formation resulting from the breakdown of the blood-nerve barrier. Although this edema may diffuse into CSF when the subarachnoid space is preserved, the endoneurial fluid pressure may increase when the area is closed by increased compression. On the other hand, the nerve root tissue has already degenerated under the compression and the numerous macrophages releasing various chemical mediators, aggravating radicular symptoms that appear in the area of Wallerian degeneration. Prostaglandin E1 (PGE1) is a potent vasodilator as well as an inhibitor of platelet aggregation and has therefore attracted interest as a therapeutic drug for lumbar canal stenosis. However, investigations in the clinical setting have shown that PGE1 is effective in some patients but not in others, although the reason for this is unclear.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Lumbar canal stenosis; Cauda equine; Nerve root; Prostaglandin E1; Blood flow Core tip: The radicular symptoms associated with degenerative disease of the lumbar spine are reported to be attributable to a combination of mechanical nerve root compression and resultant circulatory disturbance. Disturbance of blood flow in the cauda equina and nerve roots is reported to play an important role in the mechanism of intermittent claudication in patients with lumbar canal stenosis. Prostaglandin E1 (PGE1) is a potent vasodilator as well as an inhibitor of platelet aggregation and has therefore attracted interest as a therapeutic drug for lumbar canal stenosis with intermittent claudication. However, investigations in the clinical setting have shown that lipo-PGE1 is effective in some patients but not in others, although the reason for this is unclear.Kobayashi S. Pathophysiology, diagnosis and treatment of intermittent claudication in patients with lumbar canal stenosis. World

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“…The failure to elicit a response upon subsequent injections of prostaglandin E2 may be due to the limb vasculature being maximally dilated as suggested by Daugherty (1971). In contrast to the studies of Ducharme, Weeks & Montgomery (1968) and Greenberg & Sparks (1969), prostaglandin F2.did not induce vasoconstriction in the isolated hind limb. However, the techniques employed by these investigators were substantially different.…”

Section: Methodsmentioning

confidence: 81%

Vasoconstrictor Response to Arachidonic Acid in the Isolated Hind Limb of the Dog

Fitzpatrick

Johnson

Kot

et al. 1977

British J Pharmacology

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1Arachidonic acid (AA) (25‐200 μg/kg) produced a dose‐related increase in perfusion pressure in dog isolated hind limbs perfused with either blood or a platelet‐free perfusate. 2Prostaglandin E2 produced vasodilatation while prostaglandin produced no vascular change at these administered doses. 3Phentolamine did not alter the arachidonic acid response, eliminating possible α‐adrenoceptor mediation. 4Aspirin and indomethacin blocked the vasoconstrictor response to AA. 5This study indicates that a vasoactive intermediate in prostaglandin synthesis can be elaborated in the absence of platelets.

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Prostaglandins and consecutive vascular segments of the canine hindlimb

Cited by 47 publications

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Influence of extracellular calcium and calcium antagonists on contractions induced by potassium and prostaglandin F_2α in isolated cerebral and mesenteric arteries of the cat

Influence of extracellular calcium and calcium antagonists on contractions induced by potassium and prostaglandin F_2α in isolated cerebral and mesenteric arteries of the cat

Pathophysiology, diagnosis and treatment of intermittent claudication in patients with lumbar canal stenosis

Vasoconstrictor Response to Arachidonic Acid in the Isolated Hind Limb of the Dog

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Prostaglandins and consecutive vascular segments of the canine hindlimb

Cited by 47 publications

References 0 publications

Influence of extracellular calcium and calcium antagonists on contractions induced by potassium and prostaglandin F2α in isolated cerebral and mesenteric arteries of the cat

Influence of extracellular calcium and calcium antagonists on contractions induced by potassium and prostaglandin F2α in isolated cerebral and mesenteric arteries of the cat

Pathophysiology, diagnosis and treatment of intermittent claudication in patients with lumbar canal stenosis

Vasoconstrictor Response to Arachidonic Acid in the Isolated Hind Limb of the Dog

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Influence of extracellular calcium and calcium antagonists on contractions induced by potassium and prostaglandin F_2α in isolated cerebral and mesenteric arteries of the cat

Influence of extracellular calcium and calcium antagonists on contractions induced by potassium and prostaglandin F_2α in isolated cerebral and mesenteric arteries of the cat