Prostaglandins and the immune response

Pelus, Louis M.; Strausser, Helen R.

doi:10.1016/0024-3205(77)90274-0

Cited by 161 publications

(27 citation statements)

References 58 publications

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“…Prostaglandins were able to make macrophages and/or lymphocytes less sensitive to various stimuli (Pelus and Strausser, 1977;Schultz et al, 1978). Moreover, prostaglandin E 2 suppressed NK cells and lymphokine-activated killer (LAK) cells (Ohnishi et al, 1991;Roth and Golub, 1993;Baxevanis et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

Reaction with Fructose Detoxifies Fumonisin B₁ while Stimulating Liver-Associated Natural Killer Cell Activity in Rats

Dantzer

Hopmans

et al. 1997

J. Agric. Food Chem.

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Fumonisin B1 (FB1) was reacted with fructose in an attempt to detoxify this mycotoxin. Fischer 344/N rats were initiated with diethylnitrosamine (15 mg/kg body weight) and then fed 69.3 μmol FB1/kg diet or 69.3 μmol FB1 reacted with fructose (FB1−fructose)/kg diet for 4 weeks. In comparison with the rats fed basal diet or FB1−fructose, the FB1-fed rats had significantly increased plasma cholesterol (P < 0.01), plasma alanine aminotransferase activity (P < 0.05), and endogenous hepatic prostaglandin production (P < 0.05). Placental glutathione S-transferase-positive and γ-glutamyl transferase-positive altered hepatic foci occurred only in the FB1-fed rats. Liver-associated natural killer (NK) cell activity was significantly decreased in the FB1-fed rats and increased in the group fed FB1-fructose, as compared with the basal group (P < 0.03). Therefore, modifying FB1 with fructose seems to prevent FB1-induced hepatotoxicity and promotion of hepatocarcinogenesis while stimulating liver-associated NK cell activity in rats. Fumonisin B 1 (FB 1 ) was reacted with fructose in an attempt to detoxify this mycotoxin. Fischer 344/N rats were initiated with diethylnitrosamine (15 mg/kg body weight) and then fed 69.3 µmol FB 1 /kg diet or 69.3 µmol FB 1 reacted with fructose (FB 1 -fructose)/kg diet for 4 weeks. In comparison with the rats fed basal diet or FB 1 -fructose, the FB 1 -fed rats had significantly increased plasma cholesterol (P < 0.01), plasma alanine aminotransferase activity (P < 0.05), and endogenous hepatic prostaglandin production (P < 0.05). Placental glutathione S-transferase-positive and γ-glutamyl transferase-positive altered hepatic foci occurred only in the FB 1 -fed rats. Liver-associated natural killer (NK) cell activity was significantly decreased in the FB 1 -fed rats and increased in the group fed FB 1 -fructose, as compared with the basal group (P < 0.03). Therefore, modifying FB 1 with fructose seems to prevent FB 1 -induced hepatotoxicity and promotion of hepatocarcinogenesis while stimulating liver-associated NK cell activity in rats.

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Section: Discussionmentioning

confidence: 99%

Reaction with Fructose Detoxifies Fumonisin B₁ while Stimulating Liver-Associated Natural Killer Cell Activity in Rats

Dantzer

Hopmans

et al. 1997

J. Agric. Food Chem.

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“…The physiological relevance of these various immunoregulatory systems remains undetermined. In addition to these numerous studies showing that expression of suppressor activities requires an in vitro activation, naturally occurring suppressor lymphocytes have been shown to control the level of T and B immune responses (19)(20)(21)(22)(23) at such times as the neonatal period (24)(25)(26), late pregnancy (26), and in normal nonresponder subjects (27). The I Abbreviiations used in this paper: E-RFC, sheep erythrocytes forming rosettes; yG, gammagloblulin; HTLA, human T leukocyte antigen; ICC, immunoglobulin-containing cells; NWC, nylon wool columns; PGE2, prostaglandin E2; PWM, pokeweed mitogen; slg, surface immunoglobulins; TS, T suppressor.…”

mentioning

confidence: 99%

Dysfunctions of Pokeweed Mitogen-stimulated T and B Lymphocyte Responses Induced by Gammaglobulin Therapy

Durandy¹,

Fischer²,

Griscelli³

1981

J. Clin. Invest.

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“…Acutephase reactants present in the sera of animals and humans afflicted with both benign and malignant dis eases have the capacity to suppress immune function [16][17][18], These acute-phase reactants may account for a number of these suppressor factors demonstrated in this project. This issue could be resolved by applying the methodology utilized in this study in benign and malignant diseases resulting in immune suppression and enumerating the suppressor factors elaborated in each disease condition.…”

Section: Discussionmentioning

confidence: 99%

Heterogeneity of Soluble Suppressor Factors in Rat Malignant Ascites

Cohen¹,

Contino²,

Hensen³

et al. 1988

Oncology

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A study was undertaken to enumerate and partially characterize soluble factors generated by tumor-bearing animals capable of suppressing PHA-induced splenocyte proliferation. Sprague-Dawley rats were induced to form malignant ascites by the intraperitoneal injection of the Walker 256 carcinoma. Intact ascites suppressed splenocyte proliferation by 96%. Molecular sieving of the ascites by means of ultrafiltration (10-kilodalton particle cutoff) revealed suppressor activity to reside in both the ultrafiltrate and retentate. Further enumeration of suppressor factors was achieved by preparative polyacrylamide gel electrophoresis of the ascites ultrafiltrate and retentate. Five discrete bands of suppressor activity were resolved in the ultrafiltrate, three of which were heat-labile. Three discrete bands of suppressor activity were resolved in the retentate, none of which were heat-labile. This study underscores the complexity and heterogeneity of soluble factors elaborated in a cancer-bearing animal.

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Prostaglandins and the immune response

Cited by 161 publications

References 58 publications

Reaction with Fructose Detoxifies Fumonisin B₁ while Stimulating Liver-Associated Natural Killer Cell Activity in Rats

Reaction with Fructose Detoxifies Fumonisin B₁ while Stimulating Liver-Associated Natural Killer Cell Activity in Rats

Dysfunctions of Pokeweed Mitogen-stimulated T and B Lymphocyte Responses Induced by Gammaglobulin Therapy

Heterogeneity of Soluble Suppressor Factors in Rat Malignant Ascites

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Prostaglandins and the immune response

Cited by 161 publications

References 58 publications

Reaction with Fructose Detoxifies Fumonisin B1 while Stimulating Liver-Associated Natural Killer Cell Activity in Rats

Reaction with Fructose Detoxifies Fumonisin B1 while Stimulating Liver-Associated Natural Killer Cell Activity in Rats

Dysfunctions of Pokeweed Mitogen-stimulated T and B Lymphocyte Responses Induced by Gammaglobulin Therapy

Heterogeneity of Soluble Suppressor Factors in Rat Malignant Ascites

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Reaction with Fructose Detoxifies Fumonisin B₁ while Stimulating Liver-Associated Natural Killer Cell Activity in Rats

Reaction with Fructose Detoxifies Fumonisin B₁ while Stimulating Liver-Associated Natural Killer Cell Activity in Rats