Prostaglandins and the lung

Respiratory Syncytial Virus (RSV) Infection Induces Cyclooxygenase 2: A Potential Target for RSV Therapy

“…Eicosanoid function in the airways has been subdivided into stimulatory PGs (bronchoconstrictors) such as PGD 2 , PGF 2 ␣ and TBx, on the one hand, and inhibitory PGs (bronchodilators) such as PGE 2 , on the other (60). PGE 2 is the most abundant PG in lungs (60) and is considered to be a potent immunosuppressor. In vitro, PGE 2 activates the Th2 subset of T cells while suppressing the Th1 subset (61).…”

Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice.

“…Mast cells express surface receptors (FcER),' which bind IgE with pulmonary dynamic compliance; FceR, surface receptors that bind IgE antibodies; GL, pulmonary conductance; HR, heart rate; PEEP, positive end expiratory pressure. high affinity (6,7), priming the cells to release a variety of mediators in response to challenge with specific antigen (1)(2)(3)(4)(5)(6)(7). Second, many of the mediators released from appropriately stimulated mast cells are bronchoactive (1)(2)(3)(4)(8)(9)(10). Third, it is well established that pharmacologic agents capable of interfering with mast cell degranulation, or with the effects of "mast cell-derived" mediators, can inhibit anaphylactic responses (1 1-15).…”

Pulmonary Pharmacology of DT-TX 30 SE, a Potent Selective Combined Thromboxane Synthetase Inhibitor and Receptor Antagonist, in Guinea Pigs

“…It is a potent platelet aggregating agent and may therefore play a role in pulmonary thrombosis (1).…”