Prostaglandins for preventing postpartum haemorrhage

Gülmezoglu, A Metin; Forna, Fatu; Villar, José; Hofmeyr, G Justus

doi:10.1002/14651858.cd000494.pub3

Cited by 122 publications

(130 citation statements)

References 93 publications

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“…6 Some evidence suggests that the uterotonic component can be eff ective on its own. 8,9 However, the contribution of controlled cord traction is largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Active management of the third stage of labour with and without controlled cord traction: a randomised, controlled, non-inferiority trial

Gülmezoglu¹,

Lumbiganon²,

Landoulsi³

et al. 2012

The Lancet

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127

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Active management of the third stage of labour with and without controlled cord traction: a randomised, controlled, non-inferiority trial. Lancet, 379 (9827 A Metin Gülmezoglu, Pisake Lumbiganon, Sihem Landoulsi, Mariana Widmer, Hany Abdel-Aleem, Mario Festin, Guillermo Carroli, Zahida Qureshi, João Paulo Souza, Eduardo Bergel, Gilda Piaggio, Shivaprasad S Goudar, John Yeh, Deborah Armbruster, Mandisa Singata, Cristina Pelaez-Crisologo, Fernando Althabe, Peter Sekweyama, Justus Hofmeyr, Mary-Ellen Stanton, Richard Derman, Diana Elbourne SummaryBackground Active management of the third stage of labour reduces the risk of post-partum haemorrhage. We aimed to assess whether controlled cord traction can be omitted from active management of this stage without increasing the risk of severe haemorrhage.

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“…6 Some evidence suggests that the uterotonic component can be eff ective on its own. 8,9 However, the contribution of controlled cord traction is largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Active management of the third stage of labour with and without controlled cord traction: a randomised, controlled, non-inferiority trial

Gülmezoglu¹,

Lumbiganon²,

Landoulsi³

et al. 2012

The Lancet

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127

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“…17 Studies have shown that Misoprostol is not as effective as Oxytocin for the prevention of PPH and that maternal pyrexia is a significant adverse effect. 14,16,[18][19][20] However, misoprostol is a suitable agent for management of the third stage of labour when other agents are not available for reasons of cost, storage, or difficulty of administration. 18,21,22. Though blood loss in group C was comparatively higher, there were no values found more than 200 ml.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of efficacy of oxytocin, methylergometrine and misoprostol in prevention of post-partum haemorrhage

Alam

Shyam

Goswami

2017

Int J Reprod Contracept Obstet Gynecol

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Background: To compare the efficacy of oxytocin, methylergometrine and misoprostol in active management of third stage of labour (AMTSL).Methods: A clinical study was conducted on 330 low risk pregnant women with a healthy singleton pregnancy and spontaneous onset of labour at term; allocated into three groups where active management of third stage of labour was done with either Oxytocin 10 IU intramuscular, or Methylergometrine 0.2 mg intramuscular, or tab Misoprostol 600µg sublingual on 110 women each group. Primary parameter was blood loss during labour. Secondary parameters were the duration of third stage of labour and changes in haemoglobin level.Results: Blood loss during labour in Oxytocin group was 145.86±11.53 ml, which was significantly less than that in Methylergometrine (164.02±9.36 ml) and Misoprostol groups (183.18±9.70 ml), but no patient in any of the groups had blood loss more than 200ml. Duration of third stage of labour was significantly less in Oxytocin group (5.13±1.91 mins) than in. Methylergometrine (6.16±1.85 mins), and Misoprostol groups (6.47±1.51 mins). No patient had prolonged third stage in any of the groups. There was no significant change in pre-and post-delivery haemoglobin levels in all the groups.Conclusions: Though injectable uterotonics are effective for active management of third stage of labour (AMTSL), misoprostol can also be effectively used, especially in settings where there is no adequate trained personnel and drug storage facility.

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“…4 The need for standardized treatment protocols has been emphasized recently, although which uterotonics should be used remains controversial. 5,6 Many hospitals currently run drills to train their staff using standardized protocols to recognize and treat PPH. 7,8 Although the emphasis to date has been on early diagnosis and treatment, primary prevention of PPH has remained elusive.…”

Section: Introductionmentioning

confidence: 99%

Identifying women most likely to benefit from prevention strategies for postpartum hemorrhage

Korst

Fridman³

et al. 2009

J Perinatol

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Objective: To identify women who are most likely to benefit from primary prevention strategies for postpartum hemorrhage (PPH).Study Design: In a retrospective patient cohort, we applied recursive partitioning algorithms to identify the most discriminant risk factors and their interactions, and calculated the 'number needed to treat' to prevent a single case of PPH (estimated blood loss >1000 ml).Result: By delivery category, the highest risk groups with 'number needed to treat' ranging from 4 to 7 were: (1) vaginal delivery (PPH ¼ 0.7% of 16 218)Fmacrosomia with gestational diabetes and manual removal of the placenta; (2) primary cesarean (PPH ¼ 18.7% of 2696)Fmacrosomia and multiparity; and (3) repeat cesarean (PPH ¼ 16.0% of 1832)Futerine incision other than low transverse and failed vaginal birth after cesarean. Conclusion:Clinical profiles that identify women at risk for PPH can provide a foundation for the development of primary prevention strategies.

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Prostaglandins for preventing postpartum haemorrhage

Cited by 122 publications

References 93 publications

Active management of the third stage of labour with and without controlled cord traction: a randomised, controlled, non-inferiority trial

Active management of the third stage of labour with and without controlled cord traction: a randomised, controlled, non-inferiority trial

A comparative study of efficacy of oxytocin, methylergometrine and misoprostol in prevention of post-partum haemorrhage

Identifying women most likely to benefit from prevention strategies for postpartum hemorrhage

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