Prostaglandins in androgenetic alopecia in 12 men and four female

Villarreal-Villarreal, César Daniel; Sinclair, Rodney; Martínez-Jacobo, Lizeth; Garza‐Rodríguez, Verónica; Rodríguez‐León, S.A.; Lamadrid‐Zertuche, A.C.; Rodríguez-Gutiérrez, René; Ortı́z-López, Rocio; Rojas-Martı́nez, Augusto; Ocampo‐Candiani, Jorge

doi:10.1111/jdv.15479

Cited by 12 publications

(13 citation statements)

References 10 publications

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“…Testosterone and testicular secretion assist in restoration and increase of the L-PGDS level in rat epididymis after castration 16 . Furthermore, L-PGDS/PGD 2 mediates androgen-induced male alopecia (AGA) 17 , which is subsequently associated with a high incidence of BPH 18 . Our previous study found that after BPA administration, the PGDS transcription is increased, which might lead to the occurrence of prostate hyperplasia 19 .…”

Section: Introductionmentioning

confidence: 99%

The prostaglandin synthases, COX-2 and L-PGDS, mediate prostate hyperplasia induced by low-dose bisphenol A

Huang

et al. 2020

Sci Rep

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This study aimed to identify prostaglandin synthases (PGS) that mediate bisphenol A (BPA)-induced prostatic hyperplasia and explore their underlying mechanisms. In an in vivo study, male adult Sprague-Dawley rats were treated with different concentrations of BPA (10, 30, 90, or 270 μg/ kg, i.g., daily), or with vehicle for 4 weeks. Results revealed that low-dose BPA induced prostatic hyperplasia with increased PCNA/TUNEL ratio. It significantly upregulated the expression of cyclooxygenase-2 (COX-2) and NF-κB in the dorsolateral prostate (P < 0.05) and the expression of lipocalin-type prostaglandin D synthase (L-PGDS) in ventral prostate (P < 0.05). The level of estradiol (E 2)/testosterone (T) and expression of androgen receptor (AR) and estrogen receptor α (ERα) were also altered. In vitro studies showed that low-dose BPA (0.1-10 nM) promoted the proliferation of human prostate fibroblasts and epithelial cells, and significantly upregulated the expression of COX-2 and L-PGDS in the cells. The two types of cell proliferation induced by BPA were inhibited by COX-2 inhibitor (NS398) and L-PGDS inhibitor (AT56), with increased apoptosis level. These findings suggested that COX-2 and L-PGDS could mediate low-dose BPA-induced prostatic hyperplasia through pathways involved in cell proliferation and apoptosis, which might be related to the functions of ERα and AR. The role of COX-2/NF-κB pathway in dorsolateral prostate requires further research. Bisphenol A (BPA) is a synthetic plasticizer that is widely used to package daily necessities 1. Environmental exposure to BPA has potential toxicity to the tissues of male system including those of the testes and prostate 2 , leading to abnormal prostate development and a trend of hyperplasia 3. Prostate epithelial cells and prostate fibroblasts are the two main cell that constitute prostate tissues. Excessive proliferation of epithelial cells and prostate fibroblasts, and the transformation of epithelial cells to mesenchymal cells are involved in the pathogenesis of prostate hyperplasia 4,5. Low-dose BPA (0.01-1 nM) has been reported to promote the proliferation of primary prostate epithelial cells in rats 6. Similar to estradiol (E 2), BPA promotes the proliferation of human prostate epithelial stem cells and increases the possibility of human prostate epithelial carcinoma 7. However, the underlying mechanism of its effect on prostate cell proliferation and prostate hyperplasia remains unclear. As a typical environmental endocrine disruptor (EDC), BPA can disturb the endocrine functions by mimicking, enhancing, or inhibiting the endogenous estrogen activity, interfering with the androgen system 8 , and affecting the expressions of endocrine hormone-related genes and pathways. Prostaglandin synthases (PGS) catalyze the formation of different active prostaglandins (PGs) in the arachidonic acid metabolic pathway. There are four main PGS that are closely associated with hormonal function. Cyclooxygenase-2 (COX-2) is an inducible prostaglandin H synthase that is less expressed i...

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Section: Introductionmentioning

confidence: 99%

The prostaglandin synthases, COX-2 and L-PGDS, mediate prostate hyperplasia induced by low-dose bisphenol A

Huang

et al. 2020

Sci Rep

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“…It is well established that certain prostaglandins (PG) such as PGD2, which may be released after reactive oxygen species induced tissue damage, may have a crucial role in the pathogenesis of androgenetic alopecia by increasing testosterone. This pathway may be one of the possible effects of DXP on androgenetic alopecia 22‐24 . Of note, a previous animal study reported that bristles of the female swine suffering from a deficiency of pantothenic acid loosen and fall, in particular on the rump and along the spine 25 .…”

Section: Discussionmentioning

confidence: 96%

Systemic dexpanthenol as a novel treatment for female pattern hair loss

Kutlu

Metin

2020

J of Cosmetic Dermatology

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Background There are only a few drugs that have been used for the treatment of female pattern hair loss (FPHL). Aims Through use of the Dermatologic Life Quality Index (DLQI) and a modified hair growth questionnaire, we aimed to evaluate the effect of dexpanthenol (DXP) as a new option for FPHL. Methods Women who received 500 mg intramuscular DXP weekly for FPHL were included in this study. They were evaluated in terms of DLQI and laboratory characteristics, before and after DXP treatment, and were examined with a modified hair growth questionnaire. Results Overall satisfaction with the appearance of the hair was described by the patients as 57.1% “ I am satisfied,” 28.6% “I am very satisfied,” and 14.3% “I am neutral (neither satisfied nor dissatisfied).” There was a statistical difference between the mean DLQI scores before and after DXP treatment (P < .001). No statistical difference was found in the laboratory characteristics of the patients before and after DXP treatment (P > 0.05). No side effect was reported during DXP treatment. Conclusion Dexpanthenol is a safe and novel drug that may increase the quality of life in patients with FPHL.

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“…Based on many previous studies, this review provides that there is a highly remarkable correlation between the expression levels of PGs and hair growth. Four major PGs including PGD 2 , PGI 2 , PGE 2 , and PGF 2α are implicated in the pathogenesis of the hair loss pattern of both males and females [ 10 , 11 , 16 , 35 , 61 ]. That is, PGD 2 and PGI 2 contribute to inhibiting hair growth, On the other hand, PGE 2 and PGF 2α contribute to promoting hair growth.…”

Section: Discussionmentioning

confidence: 99%

The physiological and pharmacological roles of prostaglandins in hair growth

Shin

2022

Korean J Physiol Pharmacol

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Hair loss is a common status found among people of all ages. Since the role of hair is much more related to culture and individual identity, hair loss can have a great influence on well-being and quality of life. It is a disorder that is observed in only scalp patients with androgenetic alopecia (AGA) or alopecia areata caused by stress or immune response abnormalities. Food and Drug Administration (FDA)-approved therapeutic medicines such as finasteride, and minoxidil improve hair loss temporarily, but when they stop, they have a limitation in that hair loss occurs again. As an alternative strategy for improving hair growth, many studies reported that there is a relationship between the expression levels of prostaglandins (PGs) and hair growth. Four major PGs such as prostaglandin D2 (PGD 2 ), prostaglandin I2 (PGI 2 ), prostaglandin E2 (PGE 2 ), and prostaglandin F2 alpha (PGF 2 α) are spatiotemporally expressed in hair follicles and are implicated in hair loss. This review investigated the physiological roles and pharmacological interventions of the PGs in the pathogenesis of hair loss and provided these novel insights for clinical therapeutics for patients suffering from alopecia.

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Prostaglandins in androgenetic alopecia in 12 men and four female

Cited by 12 publications

References 10 publications

The prostaglandin synthases, COX-2 and L-PGDS, mediate prostate hyperplasia induced by low-dose bisphenol A

The prostaglandin synthases, COX-2 and L-PGDS, mediate prostate hyperplasia induced by low-dose bisphenol A

Systemic dexpanthenol as a novel treatment for female pattern hair loss

The physiological and pharmacological roles of prostaglandins in hair growth

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