Prostaglandins in Hematology

Abstract

Prostaglandin E, (PGE,)

Energized endocytosis in human erythrocyte ghosts.

“…Study of the possible role of prostaglandin E1 and E2 was prompted by their reported ability to alter erythrocyte membrane deformability (31) when Ca is added to the suspending media (36). Our studies revealed no effect of prostaglandin E1 and E2 on endocytosis, Ca efflux, or Ca,Mg-ATPase, in the concentration range that produces (36) (Table IV) (Fig.…”

“…Prostaglandins E1 and E2 have been shown to affect the deformability characteristics of intact erythrocytes (31). Since the deformability of the erythrocyte is under metabolic control, represented in part by erythrocyte ATP content and in part by its Ca content (32,33) it was hypothesized that PGE1 and PGE2 might exert their membrane effects by perturbing either Ca efflux, endocytosis, or the membrane-associated Ca,Mg-ATPase.…”

Regulation of membrane flexibility in human erythrocytes

“…These studies suggest but do not prove that the flexibility of an isolated erythrocyte can be controlled by these substances. Studies by Allen and Valeri (1974) indicate further that erythrocyte morphology is regulated by low concentrations of the prostaglandins PGE1,' or PGE2, which can decrease, or increase, respectively, the internal volume of the cell by a small amount (-3%). The paramagnetic resonance spectra of fatty acid spin-labels bound nonspecifically to these membranes show small but reproducible changes on the addition of low concentrations ( 10-'o-10-'2 M ; of the order of few molecules per cell) of the prostaglandins PGEl and PGE2 (Kury et al, 1974), and also show reproducible changes on the addition of physiological concentrations of adrenaline and carbamyl choline (Huestis and McConnell, 1974).…”

Effects of intra‐arterial prostaglandin E1 in patients with peripheral arterial occlusive disease

“…This is proved by our xenon clearance examinations and the favourable shifts of the muscle oxygen pressure histograms. This effect is probably due to increased deformability of red blood cells and inhibition of platelet aggregation [34].…”