1989
DOI: 10.1097/00005176-198910000-00010
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Prostaglandins in the Plasma and Stool of Children with Rotavirus Gastroenteritis

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Cited by 33 publications
(35 citation statements)
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“…Our results are in agreement with other studies in which elevated levels of PGE 2 and PGF 2 were detected in the plasma and stool of rotavirus-infected children (66) and elevated intestinal PGE 2 concentrations were found in piglets early after rotavirus infection (69). In addition, many other viruses are known to modify COX-2 expression and PG production (29,33,34,37,43,47,59,67).…”
Section: Discussionsupporting
confidence: 93%
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“…Our results are in agreement with other studies in which elevated levels of PGE 2 and PGF 2 were detected in the plasma and stool of rotavirus-infected children (66) and elevated intestinal PGE 2 concentrations were found in piglets early after rotavirus infection (69). In addition, many other viruses are known to modify COX-2 expression and PG production (29,33,34,37,43,47,59,67).…”
Section: Discussionsupporting
confidence: 93%
“…This indicates that COX inhibitors might have a broad effect on rotavirus infection, blocking rotaviruses of different serotypes and with different species specificity. In addition, our findings are in agreement with the observations that the duration of rotavirus diarrheal illness in young children is reduced after oral administration of aspirin, a nonspecific COX inhibitor similar to indomethacin (19,56,66), and that indomethacin abolished rotavirus-induced secretion of potassium ions in infected piglet jejunum (65).…”
Section: Discussionsupporting
confidence: 91%
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“…Loperamide is such as a drug, reducing intestinal motility by acting on opioid receptors on the myenteric plexa. However, there are contradictive studies whether loperamide reduces rotavirus diarrhea 105,106 . Increased motility has been observed in rotavirus infected mice 99 which was reduced by loperamide 99 .…”
Section: Increased Motilitymentioning
confidence: 99%
“…Furthermore, loperamide can inhibit intestinal secretion caused by bacterial enterotoxins (24,25). Regarding RV infections, Yamashiro and coworkers (26) found a significant effect of the stool score on days 3 to 5 of treatment. Meta-analyses confirmed that patients treated with loperamide are less likely to have diarrhea 24 h after treatment and present with a shorter duration of diarrhea and fewer stools than patients in the placebo group (27).…”
mentioning
confidence: 99%