Prostanoid Release in Experimental Liver Transplantation

Post, Stefan; Goerig, M.; Otto, Gerhard; Männer, M.; Senninger, N.; Kommerell, B; Herfarth, Christian

doi:10.1097/00007890-199003000-00002

Cited by 33 publications

(14 citation statements)

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“…Vasoactive agents liberated from the liver after initiation of reperfusion have been proposed as the responsible factors underlying the pathophysiology of transplantation-related liver failure. The levels of prostanoids in the hepatic vein immediately after liver grafting are markedly increased, 57 and this is significantly associated with poor early graft function. 58 Thus, pretreatment with TXA 2 synthase inhibitor not only significantly reduced the serum levels of TXA 2 but also provided a better graft function and survival rate after liver transplantation.…”

Section: Ischemia-reperfusion-induced Hepatic Injurymentioning

confidence: 99%

Role of Thromboxane in Producing Hepatic Injury During Hepatic Stress

Yokoyama

Nimura²,

Nagino³

et al. 2005

Arch Surg

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Section: Ischemia-reperfusion-induced Hepatic Injurymentioning

confidence: 99%

Role of Thromboxane in Producing Hepatic Injury During Hepatic Stress

Yokoyama

Nimura²,

Nagino³

et al. 2005

Arch Surg

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“…Experimental models suggest a role for initiating mediator of reperfusion injury. In this study, OKY046 decreased TXA synthesis during preservation prostanoid immediately after reprefusion [17][18][19][20]. Post et al [17,18] demonstrated a massive intrahepatic re-and perfusion, but OKY046 did not increase PGI synthesis during preservation.…”

Section: Figmentioning

confidence: 74%

“…In this study, OKY046 decreased TXA synthesis during preservation prostanoid immediately after reprefusion [17][18][19][20]. Post et al [17,18] demonstrated a massive intrahepatic re-and perfusion, but OKY046 did not increase PGI synthesis during preservation. Histologically, OKY046 reduced lease of prostanoids during the first minutes after reperfusion in porcine hepatic allografts but they were unable the amount of reperfusion damage of the sinusoidal endothelial cells and the hepatocytes.…”

Section: Figmentioning

confidence: 74%

Thromboxane A2in Preservation-Reperfusion Injury: The Effect of Thromboxane A2Synthetase Inhibitor

Suehiro

Yanaga

Itasaka

et al. 1996

Journal of Surgical Research

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“…These data have been confirmed in clinical liver transplantation. One explanation for the beneficial effect of a protein flushout after cold ischemia may be the removal of cytotoxic end products of metabolism such as free fatty acids, thromboxane or leukotrienes which can cause reperfusion injury [19,20]. The same effect might be true for a protein flushout after hyperthermic isolated liver perfusion.…”

Section: Discussionmentioning

confidence: 99%

Isolated Hyperthermic Liver Perfusion with High Dose Tumor Necrosis Factor Alpha in Pigs: An Experimental Study in Preparation of Clinical Use

Lang¹,

Thyen²,

Nadalin³

et al. 2000

Eur Surg Res

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Isolated hyperthermic perfusion of the liver was performed for 45 min in 27 pigs via hepatic artery and portal vein at mean inflow temperatures between 40.7 and 41.2°C. In two study groups B and C (n = 9 pigs each) 50 μg recombinant human tumor necrosis factor-α (rhTNFα) per kg body weight were added to the perfusate, whereas in a control group A liver perfusion was done without rhTNFα. Before reperfusion the livers were washed out with Ringer’s solution in all groups followed by a protein solution in group C. At 30 and 60 min after reperfusion the maximum systemic rhTNFα concentrations were significantly higher in group B with 68 and 61 ng/ml compared to 14.5 and 14.9 ng/ml in group C (p < 0.05). Mean systemic porcine TNFα concentration was significantly higher in group B (217 pg/ml) compared to group C (50 pg/ml) 30 min after reperfusion (p = 0.012). Survival was 7/9 in group A and C and only 2/9 in group B with 6/7 pigs dying due to severe cardiopulmonary failure within 12 h after operation. In surviving pigs of group A and C only mild and transient hepatotoxicity was registered. The presented study underlines the feasibility of high dose rhTNFα application in an isolated hyperthermic liver perfusion system. Washout of the liver with a protein solution before reperfusion reduces systemic TNFα levels as well as associated lethal cardiocirculatory and hepatotoxic side effects.

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Prostanoid Release in Experimental Liver Transplantation

Cited by 33 publications

References 0 publications

Role of Thromboxane in Producing Hepatic Injury During Hepatic Stress

Role of Thromboxane in Producing Hepatic Injury During Hepatic Stress

Thromboxane A2in Preservation-Reperfusion Injury: The Effect of Thromboxane A2Synthetase Inhibitor

Isolated Hyperthermic Liver Perfusion with High Dose Tumor Necrosis Factor Alpha in Pigs: An Experimental Study in Preparation of Clinical Use

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