Prostate and seminal vesicle volume based consideration of prostate cancer patients for treatment with 3D‐conformal or intensity‐modulated radiation therapya)

Reddy, Nandanuri M. S.; Nori, Dattatreyudu; Chang, Hye-Sook; Lange, Christopher S.; Ravi, A.

doi:10.1118/1.3451125

Cited by 11 publications

(11 citation statements)

References 34 publications

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“…Very large prostate gland size may be a challenge for EBRT planning, because larger PTVs make it more challenging to meet planning objectives for bladder and rectum 118 . Short-term androgen deprivation therapy (ADT) may downsize large prostate glands before brachytherapy to mitigate concerns regarding pubic arch interference and toxicity 119, 120.…”

Section: Techniques Of Patient Immobilization and Setupmentioning

confidence: 99%

ACR Appropriateness Criteria ® external beam radiation therapy treatment planning for clinically localized prostate cancer, part I of II

Zaorsky

Showalter

Ezzell

et al. 2017

Advances in Radiation Oncology

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Section: Techniques Of Patient Immobilization and Setupmentioning

confidence: 99%

ACR Appropriateness Criteria ® external beam radiation therapy treatment planning for clinically localized prostate cancer, part I of II

Zaorsky

Showalter

Ezzell

et al. 2017

Advances in Radiation Oncology

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“…5,[7][8][9] For example, in a study of the dose sparing of parotid glands for head-and-neck (HN) cancer patients, Hunt et al found that percent gland volume overlapping with PTV could predict the mean gland dose. 7 In prostate cancer cases, Reddy et al reported that the mean dose to rectum and bladder increased with increasing prostate volume.…”

Section: Introductionmentioning

confidence: 99%

“…7 In prostate cancer cases, Reddy et al reported that the mean dose to rectum and bladder increased with increasing prostate volume. 8 Moore et al demonstrated a correlation between the fraction of OAR volume overlapping with PTV and the OAR mean dose, and used the correlation to formulate a tool of quality control for the IMRT plans. 9 Further, Zhu et al proposed the concept of distance-to-target histogram (DTH) to establish the correlation between the OAR-PTV anatomy and OAR dose-volume histograms (DVHs).…”

Section: Introductionmentioning

confidence: 99%

Modeling the dosimetry of organ‐at‐risk in head and neck IMRT planning: An intertechnique and interinstitutional study

Lian

Yuan

et al. 2013

Medical Physics

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Purpose:To build a statistical model to quantitatively correlate the anatomic features of structures and the corresponding dose-volume histogram (DVH) of head and neck (HN) Tomotherapy (Tomo) plans. To study if the model built upon one intensity modulated radiation therapy (IMRT) technique (such as conventional Linac) can be used to predict anticipated organs-at-risk (OAR) DVH of patients treated with a different IMRT technique (such as Tomo). To study if the model built upon the clinical experience of one institution can be used to aid IMRT planning for another institution. Methods: Forty-four Tomotherapy intensity modulate radiotherapy plans of HN cases (Tomo-IMRT) from Institution A were included in the study. A different patient group of 53 HN fixed gantry IMRT (FG-IMRT) plans was selected from Institution B. The analyzed OARs included the parotid, larynx, spinal cord, brainstem, and submandibular gland. Two major groups of anatomical features were considered: the volumetric information and the spatial information. The volume information includes the volume of target, OAR, and overlapped volume between target and OAR. The spatial information of OARs relative to PTVs was represented by the distance-to-target histogram (DTH). Important anatomical and dosimetric features were extracted from DTH and DVH by principal component analysis. Two regression models, one for Tomotherapy plan and one for IMRT plan, were built independently. The accuracy of intratreatment-modality model prediction was validated by a leave one out cross-validation method. The intertechnique and interinstitution validations were performed by using the FG-IMRT model to predict the OAR dosimetry of Tomo-IMRT plans. The dosimetry of OARs, under the same and different institutional preferences, was analyzed to examine the correlation between the model prediction and planning protocol. Results: Significant patient anatomical factors contributing to OAR dose sparing in HN Tomotherapy plans have been analyzed and identified. For all the OARs, the discrepancies of dose indices between the model predicted values and the actual plan values were within 2.1%. Similar results were obtained from the modeling of FG-IMRT plans. The parotid gland was spared in a comparable fashion during the treatment planning of two institutions. The model based on FG-IMRT plans was found to predict the median dose of the parotid of Tomotherapy plans quite well, with a mean error of 2.6%. Predictions from the FG-IMRT model suggested the median dose of the larynx, median dose of the brainstem and D2 of the brainstem could be reduced by 10.5%, 12.8%, and 20.4%, respectively, in the Tomo-IMRT plans. This was found to be correlated to the institutional differences in OAR constraint settings. Re-planning of six Tomotherapy patients confirmed the potential of optimization improvement predicted by the FG-IMRT model was correct. The institutional clinical experience was incorporated into the model which allows the model from one institution to generate a reference plan for another ...

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“…However, the detection of SVI and extracapsular extension using MRI results in alteration of target volumes for radiation therapy (Chang et al, 2014). In one study, combined prostate and SV volumes facilitated selection of conformal (CRT) or intensity modulated radiation therapy (IMRT), with volumes < 85 cm 3 supporting the use of CRT and volumes >85 cm 3 supporting the use of IMRT based on total radiation dose delivered (Reddy et al, 2010). Moreover, in a study by Xin et al, it has been shown that the recommended target distances of 1 and 2cm form the starting point of SVs for definitive radiotherapy are inadequate as the actual anatomical SVs are not covered in 62.3% and 71.0% of cases depending on the guideline preferred (Qi et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

The association between seminal vesicle size and duration of abstinence from ejaculation

et al. 2016

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There are few data describing the relationship between seminal vesicle (SV) size and duration of abstinence between ejaculations. This study evaluates the association between SV size and duration of abstinence from ejaculation using pelvic magnetic resonance imaging(MRI).Sexually active men 18–68 years old who underwent pelvic MRI for various medical indications were included. The date of last ejaculation was recorded, and the cross-sectional areas of the right and left seminal vesicles were calculated separately using mediolateral and anteroposterior measurements on T2 weighted MRI images. The association between SV area and duration of abstinence between ejaculations was determined via linear regression analysis. The study cohort consisted of 104 men with a mean age of 46.45±11.4 (range 18–68)years old. Mean right and left SV cross-sectional areas were 744.1±351.1 (range: 149.9–1794.7) mm2 and 727.6±359.2 (range 171.4 to 2248.4) mm2, respectively. The mean duration of abstinence between ejaculations in the cohort was 3.6±2.6 (range 1–15) days. Although no correlation between age and SV area was observed (r=0.007, p = 0.947),linear regression analysis demonstrated a positive correlation between SV area and the duration of abstinence from ejaculation(r=0.372, p=0.0001).SV cross-sectional area increases with duration of abstinence from ejaculation and can be assessed using MRI. The use of SV size estimation may be applicable in diagnosis, risk stratification, and treatment of urological diseases.

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Prostate and seminal vesicle volume based consideration of prostate cancer patients for treatment with 3D‐conformal or intensity‐modulated radiation therapya)

Cited by 11 publications

References 34 publications

ACR Appropriateness Criteria ® external beam radiation therapy treatment planning for clinically localized prostate cancer, part I of II

ACR Appropriateness Criteria ® external beam radiation therapy treatment planning for clinically localized prostate cancer, part I of II

Modeling the dosimetry of organ‐at‐risk in head and neck IMRT planning: An intertechnique and interinstitutional study

The association between seminal vesicle size and duration of abstinence from ejaculation

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