Prostate Cancer and Prostatic Diseases Best of Asia, 2019: challenges and opportunities

Zhu, Yao; Freedland, Stephen J.; Ye, Dingwei

doi:10.1038/s41391-019-0193-7

Cited by 16 publications

(14 citation statements)

References 12 publications

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“…However, there is a recent trend of a rising incidence of prostate cancer in Asia, which is attributed to the longer lifespan and the “westernization” of lifestyle and diet intake [ 15 ]. Increased awareness and accessibility to serum PSA screening also allows early-stage and lower-grade prostate cancers to be diagnosed [ 16 ].…”

Section: Active Surveillance In Asiamentioning

confidence: 99%

Multiparametric MRI in Active Surveillance of Prostate Cancer: An Overview and a Practical Approach

Lee

Tan

2021

Korean J Radiol

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MRI has become important for the detection of prostate cancer. MRI-guided biopsy is superior to conventional systematic biopsy in patients suspected with prostate cancer. MRI is also increasingly used for monitoring patients with low-risk prostate cancer during active surveillance. It improves patient selection for active surveillance at diagnosis, although its role during follow-up is unclear. We aim to review existing evidence and propose a practical approach for incorporating MRI into active surveillance protocols.

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Section: Active Surveillance In Asiamentioning

confidence: 99%

Multiparametric MRI in Active Surveillance of Prostate Cancer: An Overview and a Practical Approach

Lee

Tan

2021

Korean J Radiol

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“…Incorporating equations (8) and (9) into equation (7), the relationship between the deflection angle φ of the puncture needle, the puncture force Fz, and the puncture moment Mzx can be obtained when z = L. Because the puncture needle is fixed on the base at the end of the robot, the influence of the puncture torque Mzx can be ignored.…”

Section: ) Force Analysismentioning

confidence: 99%

“…Among the diseases of the urinary system, prostate cancer is one of the most common malignant tumors in male crowd, and its incidence is increasing year by year [1], [2]. According to statistics, prostate cancer is second only to lung cancer among male patients [3]- [6], and the incidence in China and other Asian countries are also increasing and tending to be younger [7]- [13]. At present, the treatment of prostate cancer mainly uses the minimally invasive surgical method of radioactive seed implantation, and the traditional surgery is mainly performed by doctors manually or using robots to complete related operations [14].…”

Section: Introductionmentioning

confidence: 99%

Study on the Control Method and Optimization Experiment of Prostate Soft Tissue Puncture

Zhang

Liu

2020

IEEE Access

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In the treatment of prostate cancer patients, surgery of radioactive seed implantation with the puncture robots is an effective treatment method. However, when the puncture needle enters the lesion tissue, there are complicated forces between the needle body and the soft tissue, which leads to the drift of the prostate and the deflection of the puncture needle, thereby affecting the puncture accuracy. In order to improve the positioning accuracy and ensure the best treatment effect, a sine rotation continuous puncture control method was proposed in this paper. First, by analyzing the interaction between the puncture needle and the soft tissue, the force balance equation and the deflection equation were established, according to the equations, it could be known that puncture friction is the main factor affecting the deflection of the puncture needle. Second, combined with the influence of puncture friction and the research on the theory of rotation puncture, the sine rotation puncture method was compared with the direct puncture method and the existing rotation puncture method; Observed with a 4D Color Doppler Ultrasound to verify the feasibility of the rotating puncture theory and the effectiveness of the sine rotation puncture method. Third, through the establishment of Euler Beam model, rotation angle analysis and puncture velocity test analysis, the influence of dynamic parameters of this method on the puncture accuracy was discussed, the optimization range of each factor was obtained; The experiment was designed by the quadratic regression orthogonal combination theory, the experiment process was observed and recorded by a 3D X-ray scanner, the regression equations were established between experiment factors and experiment indicators with the Design-Expert, and the best parameter combinations were acquired through optimization. Last, comparison tests and verification test were carried out to verify the rationality and reliability of the optimized sine rotation puncture control method.

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“…Prostate cancer is the most common malignant tumor among men in developed countries (1). In recent years, prostate cancer has contributed to a high morbidity and mortality in most native Asian populations, with >297,000 new prostate cancer cases diagnosed in Asia, accounting for 23.3% of the global incidence and ~33% of deaths occurring in Asia in 2018 (2,3). Currently, prostate gland removal and androgen blockade is an effective treatment option for the majority of patients with prostate cancer; however, a number of patients experience hormone resistance, and prostatectomy is dangerous for older patients with cardiovascular disease (4).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑137 regulates hypoxia‑mediated migration and epithelial‑mesenchymal transition in prostate cancer by targeting LGR4 via the EGFR/ERK signaling pathway

et al. 2020

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MicroRNAs (miRs) serve an integral role in prostate cancer. The present study aimed to investigate the effects and mechanisms of miR-137 in hypoxia-mediated migration and epithelial-mesenchymal transition (EMT). PC3 and DU145 prostate cancer cells were exposed to hypoxia for 24 h, after which the expression of miR-137 was determined by reverse transcription-quantitative PCR (RT-qPCR). The cells were transfected with a miR-137 mimic or inhibitor, followed by hypoxia exposure. The results demonstrated that hypoxia reduced miR-137 expression. Further results from the Cell Counting Kit-8, Cell Death Detection ELISA plus kit, Transwell assay, RT-qPCR and western blotting assays revealed that the miR-137 mimic prevented cell proliferation, facilitated apoptosis and repressed cell migration, invasiveness, and expression of N-cadherin, vimentin and matrix metalloproteinase 2; the miR-137 inhibitor exerted the opposite effects. A dualluciferase reporter assay determined that miR-137 directly targeted leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4). Additionally, miR-137 negatively regulated the epidermal growth factor receptor/extracellular signalregulated kinase (EGFR/ERK) signaling pathway by targeting LGR4. LGR4 silencing or EGFR/ERK inhibition abolished the effects of miR-137 inhibitor on cell migration and EMT. In conclusion, by targeting LGR4 via the EGFR/ERK signaling pathway, miR-137 inhibited prostate cancer cell migration and EMT.

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Prostate Cancer and Prostatic Diseases Best of Asia, 2019: challenges and opportunities

Cited by 16 publications

References 12 publications

Multiparametric MRI in Active Surveillance of Prostate Cancer: An Overview and a Practical Approach

Multiparametric MRI in Active Surveillance of Prostate Cancer: An Overview and a Practical Approach

Study on the Control Method and Optimization Experiment of Prostate Soft Tissue Puncture

MicroRNA‑137 regulates hypoxia‑mediated migration and epithelial‑mesenchymal transition in prostate cancer by targeting LGR4 via the EGFR/ERK signaling pathway

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