Prostate cancer, chronic myelogenous leukemia and multiple myeloma in a single patient: a case report and review of the literature

Abstract

Background Synchronous or metachronous multiple primary malignancies (MPMs) are a known phenomenon. These occurrences may be spontaneous or related to environmental risk factors or genetic predisposition. Chronic myelogenous leukemia (CML) and Multiple myeloma (MM) are two uncommon hematologic malignancies, arises from two different cell lineage. The coexistence of CML and MM that is a rare phenomenon, with only 29 cases reported in the literature. To the best of our, this combination of triple primary cancers has not been reported in a single patient. Case presentation Herein, we reported a case of an 85-year-old Iranian male with three confirmed primary malignant neoplasms. The patient presented with synchronous prostate cancer and CML, in august 2016. He received imatinib and nilotinib for CML and hormonal therapy for prostate cancer. He remained in good control at further follow-ups for about 5 years. In the follow-up period and after 61 months treatment with tyrosine kinase inhibitors (TKIs), CML was undetectable in molecular tests, but the presence of serum M-protein, abnormal plasma cells in the bone marrow, and CRAB criteria was compatible with MM. Conclusion We must evaluate the possibility of multiple primary cancers during cancer treatment and follow-up and it may be worthwhile to monitor serum electrophoresis and protein levels in TKIs-treated patients.

Vasculitis-Like Hemorrhagic Herpes Zoster and HIV Infections: An Intricate Association

“…They generally affect the cerebral vessels and can cause damage to large and small vessels [6]. Shingles can affect both the central nervous system, causing encephalitis, and the peripheral nervous system, leading to post-herpetic neuralgia, segmental paresis, and Guillain-Barré or Hunt syndrome, respectively [7,8]. Leukocytoclastic vasculitis is a small vessel vasculitis responsible for approximately 37% of vasculitic-type phenomena due to VZV infection.…”

Association Between Synchronous Occurrence of Multiple Myeloma and Carcinoma Prostate: Literature Analysis in the Context of a Case Report

“…[8][9][10][11][12][13][14][15][16][17][18][19][20][21]. Despite an extensive search, we could find six reported cases of myeloma, four cases of metachronous diagnosis of myeloma, two cases of MGUS, two cases of smoldering myeloma, and one case of plasmacytoma with prostate carcinoma.…”