Prostate cancer

Castillejos-Molina, Ricardo; Gabilondo-Navarro, Fernando

doi:10.21149/spm.v58i2.7797

Cited by 59 publications

(43 citation statements)

References 21 publications

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“…Compared with other malignant tumours, PC cells proliferate rate is slower and it is discovered and diagnosed when urine retention and other symptoms occur [3]. In recent years, the arise of blood prostate specific antigen (PSA) has enhanced the detection rate of inchoate PC [4], but studies have demonstrated that certain organs of human can produce PSA under certain circumstances, the blood PSA lacks the specificity for diagnosing PC [5]. Therefore, there is an urgency to find new indicators for detecting inchoate PC.…”

Section: Introductionmentioning

confidence: 99%

Silencing circular RNA circZNF609 restrains growth, migration and invasion by up-regulating microRNA-186-5p in prostate cancer

Jin

Zhao

Zhang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Background: Prostate cancer (PC) fearfully impacts men's health. We explored the efficacy and mechanism of circular RNA circZNF609 (circZNF609) on colony formation, viability, apoptosis, migration and invasion and in PC cells. Methods: Colony formation, CCK-8, flow cytometry, migration and invasion assay were respectively used to detect the functions of circZNF609 and microRNA (miR)-186-5p on cell colony ability, viability, apoptosis, migration and invasion. circZNF609 and miR-186-5p expression were changed by cell transfection and tested by RT-qPCR. Moreover, Cleaved-Caspase-3, Cleaved-Caspase-9, matrix metalloproteinase-9 (MMP-9), Vimentin and relate-proteins of cell pathways were examined through Western blot. Results: circZNF609 was highly expressed at PC tissues. circZNF609 declined cell colony ability, viability, migration and invasion and caused apoptosis. Furthermore, circZNF609 negatively regulated miR-186-5p, miR-186-5p inhibitor could reverse impacts of circZNF609. Finally, circZNF609 restrained the YAP1 and AMPK pathways by up-regulating miR-186-5p. Conclusion: Silencing circZNF609 restrained growth, migration and invasion of PC cells by upregulating miR-186-5p via YAP1 and AMPK pathways. HIGHLIGHTS 1. circZNF609 is highly expressed in PC tissues; 2. circZNF609 restrains cell growth, migration and invasion; 3. circZNF609 exerts its function by up-regulating miR-186-5p; 4. circZNF609 exerts its function by YAP1 and AMPK signaling pathways.

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Section: Introductionmentioning

confidence: 99%

Silencing circular RNA circZNF609 restrains growth, migration and invasion by up-regulating microRNA-186-5p in prostate cancer

Jin

Zhao

Zhang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…Malignant tumors from the prostate are the leading cause of cancer death among adult males [ 23 ] and the mortality rate from the state de Colima, where this study took place, is one of the highest in the country [ 24 ]. High occurrence of late stages (Gleason score ≥ 7) at the time of diagnosis have been documented, in a population from northern Mexico [ 25 ], and may be determining in the observed mortality.…”

Section: Discussionmentioning

confidence: 99%

Disability-Adjusted Life Years for Cancer in 2010–2014: A Regional Approach in Mexico

Murillo-Zamora

Mendoza-Cano

Ríos-Silva

et al. 2018

IJERPH

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The disability-adjusted life years (DALYs) were used to estimate the regional (state of Colima, Mexico) cancer burden in 2010–2014. The years of life lost (YLL) were estimated with mortality data and years lived with disability (YLD) using incidence data. The DALYs were calculated as the arithmetic addition of YLL and YLD. Sex and cancer site-specific estimations were made and DALY rates were used to identify the leading causes of disease burden. Data from 2532 deaths were analyzed and, for all malignant tumors combined, 18,712.9 DALYs and 20,243.3 DALYs were estimated in males and females respectively. The overall contribution of YLL in DALY estimates was higher among females (93.7% vs. 87.4%). Age-standardized DALY rates (and 95% confidence intervals, CI) per 100,000 inhabitants were used to rank the leading causes of disease burden and, among males, malignant tumors from the prostate, lower respiratory tract, and colon and rectum accounted the highest rates (45.7, 95% CI 32.7–59.3; 37.6, 95% CI 25.7–49.9; and 25.9, 95% CI 16.0–36.1 DALYs). Breast, cervix uteri, and lower respiratory tract cancer showed the highest burden in females (66.0, 95% CI 50.3–82.4; 44.4, 95% CI 31.5–57.7; and 20.9, 95% CI 12.0–30.0 DALYs). The present study provides an indication of the burden of cancer at the regional level, underscoring the need to expand cancer prevention, screening, and awareness programs, as well as to improve early diagnosis and medical treatment.

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“…After venipuncture, the blood was stored, to be subsequently centrifuged (procedure carried out in a balanced way, checking the calibration and matching the tubes according to their physical characteristics) in pairs for 10 min at 3000 rpm, using an Inbrás ALB 18 VT Serological centrifuge (Inbrás, Ribeirão Preto, BRAZ/SP, Brazil), then the serum was transferred with the aid of an automatic pipette and variable volume to a tube properly labeled with a minimum of 2.0 mL of serum, and stored in an ice box and then transferred to the laboratory that performed the sample processing, following the Standard Operating Procedure (SOP) [ 23 ] and ARCHITECT i1000SR immunoassay analyzer (Abbott, Green Oaks, USA/IL, United States of America). A PSA level equal to or greater than 4 ng/mL was considered high [ 13 , 15 , 24 ].…”

Section: Methodsmentioning

confidence: 99%

Prevalence and Factors Associated with High Concentration of Prostate-Specific Antigen: ELSIA Study

Galvão

Tribess

Silva

et al. 2020

Biology

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Background: Prostate cancer (PC) is the second most common cancer among men, behind only non-melanoma skin cancer, and the main method of screening for PC is the prostate-specific antigen (PSA). To analyze the prevalence and the factors associated with high concentration of PSA in the elderly is essential to understand this outcome, and building strategies to decrease their rates of morbidity and mortality. Methods: We performed a cross-sectional study with 96 elderly men. A high level of PSA was defined by >4.0 ng/mL. In order to identify sociodemographic, health, functional and behavioral variables, which may be associated with high levels of PSA, we carried out a multivariate analysis using Poisson regression. Results: The prevalence of high levels of PSA was 21.9% (n = 21). High levels of PSA was associated with years of study, race/ethnicity and family arrangement, health perception, systolic blood pressure, diastolic blood pressure, metabolic diseases, alcohol consumption and sedentary behavior. Conclusions: The study found a high prevalence of high PSA concentrations in the elderly and several aspects are associated, which can be a worrying factor for their health, since PSA is an important marker of prostate cancer.

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Prostate cancer

Cited by 59 publications

References 21 publications

Silencing circular RNA circZNF609 restrains growth, migration and invasion by up-regulating microRNA-186-5p in prostate cancer

Silencing circular RNA circZNF609 restrains growth, migration and invasion by up-regulating microRNA-186-5p in prostate cancer

Disability-Adjusted Life Years for Cancer in 2010–2014: A Regional Approach in Mexico

Prevalence and Factors Associated with High Concentration of Prostate-Specific Antigen: ELSIA Study

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