Prostate Cancer Imaging and Therapy: Potential Role of Nanoparticles

Kilcoyne, Aoife; Harisinghani, Mukesh G.; Mahmood, Umar

doi:10.2967/jnumed.115.170738

Cited by 12 publications

(7 citation statements)

References 73 publications

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“…Various applications are envisioned for these materials including stand-alone biosensors, light harvesting and biocomputing devices, along with theranostics, the latter of which provides perhaps one of the more illustrative concepts reflecting the longer-term possibilities. For example, within a putative oncological theranostic device, the NP could provide MRI or other in vivo contrast while simultaneously acting as a central scaffold to host biologicals such as antibodies for tumor targeting, peptides for facilitated cellular uptake, and poorly soluble chemotherapeutics for specified delivery. , …”

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confidence: 99%

“…For example, within a putative oncological theranostic device, the NP could provide MRI or other in vivo contrast while simultaneously acting as a central scaffold to host biologicals such as antibodies for tumor targeting, peptides for facilitated cellular uptake, and poorly soluble chemotherapeutics for specified delivery. 11,12 Some types of biologically functionalized NPs, such as antibody-decorated gold colloids, have now been in use for several decades, 7 however, it is only recently that the promise and the complexity of such hybrid materials have started to be fully realized. The latter is exemplified by the many requirements surrounding the optimal assembly of these composite materials including: (i) NP synthesis, (ii) surface functionalization, and (iii) bioconjugation.…”

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confidence: 99%

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Elucidating Surface Ligand-Dependent Kinetic Enhancement of Proteolytic Activity at Surface-Modified Quantum Dots

et al. 2017

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Combining biomolecules such as enzymes with nanoparticles has much to offer for creating next generation synergistically functional bionanomaterials. However, almost nothing is known about how these two disparate components interact at this critical biomolecular-materials interface to give rise to improved activity and emergent properties. Here we examine how the nanoparticle surface can influence and increase localized enzyme activity using a designer experimental system consisting of trypsin proteolysis acting on peptide-substrates displayed around semiconductor quantum dots (QDs). To minimize the complexity of analyzing this system, only the chemical nature of the QD surface functionalizing ligands were modified. This was accomplished by synthesizing a series of QD ligands that were either positively or negatively charged, zwitterionic, neutral, and with differing lengths. The QDs were then assembled with different ratios of dye-labeled peptide substrates and exposed to trypsin giving rise to progress curves that were monitored by Förster resonance energy transfer (FRET). The resulting trypsin activity profiles were analyzed in the context of detailed molecular dynamics simulations of key interactions occurring at this interface. Overall, we find that a combination of factors can give rise to a localized activity that was 35-fold higher than comparable freely diffusing enzyme-substrate interactions. Contributing factors include the peptide substrate being prominently displayed extending from the QD surface and not sterically hindered by the longer surface ligands in conjunction with the presence of electrostatic and other productive attractive forces between the enzyme and the QD surface. An intimate understanding of such critical interactions at this interface can produce a set of guidelines that will allow the rational design of next generation high-activity bionanocomposites and theranostics.

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confidence: 99%

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confidence: 99%

Elucidating Surface Ligand-Dependent Kinetic Enhancement of Proteolytic Activity at Surface-Modified Quantum Dots

et al. 2017

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“…The term nanomaterials refer to structures of nanometric size, generally inferior to 100 nm, which may have a biologic origin, as in the case of lipid-based systems, lactic acid or dextran, as well as predominant inorganic characteristics, as in the case of polymers, silica, metals or carbon lattices [40]. One of nanomaterials' most fascinating properties lies in the possibility of functionalizing their wide surface with specific ligands, thus generating nanosized targeted vehicles of both imaging and therapeutic agents [96]. Figure 5 illustrates the variety of nanomaterials suitable for theranostics.…”

Section: Theranostic Applications Of Radioconjugated Nanomaterials Inmentioning

confidence: 99%

Prognostic and Theranostic Applications of Positron Emission Tomography for a Personalized Approach to Metastatic Castration-Resistant Prostate Cancer

Filippi

Frantellizzi

Chiaravalloti

et al. 2021

IJMS

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Metastatic castration-resistant prostate cancer (mCRPC) represents a condition of progressive disease in spite of androgen deprivation therapy (ADT), with a broad spectrum of manifestations ranging from no symptoms to severe debilitation due to bone or visceral metastatization. The management of mCRPC has been profoundly modified by introducing novel therapeutic tools such as antiandrogen drugs (i.e., abiraterone acetate and enzalutamide), immunotherapy through sipuleucel-T, and targeted alpha therapy (TAT). This variety of approaches calls for unmet need of biomarkers suitable for patients’ pre-treatment selection and prognostic stratification. In this scenario, imaging with positron emission computed tomography (PET/CT) presents great and still unexplored potential to detect specific molecular and metabolic signatures, some of whom, such as the prostate specific membrane antigen (PSMA), can also be exploited as therapeutic targets, thus combining diagnosis and therapy in the so-called “theranostic” approach. In this review, we performed a web-based and desktop literature research to investigate the prognostic and theranostic potential of several PET imaging probes, such as 18F-FDG, 18F-choline and 68Ga-PSMA-11, also covering the emerging tracers still in a pre-clinical phase (e.g., PARP-inhibitors’ analogs and the radioligands binding to gastrin releasing peptide receptors/GRPR), highlighting their potential for defining personalized care pathways in mCRPC

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“…Regarding MRI/MRT used in PCa related NP settings the number of publications is constantly increasing [104,339,340,341,342,343,344]. Jin et al, for example, evaluated MRI-guided focal NP-based (porphysomes) photothermal therapy (see below) in an orthotropic PCa mouse model, and concluded that it might be an effective and safe technique to treat PCa, with a low risk of progression of disease [343].…”

Section: Multimodal Imaging Options For Prostate and Breast Cancermentioning

confidence: 99%

Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications—Focus on Prostate and Breast Cancer

Elgqvist

2017

IJMS

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Prostate and breast cancer are the second most and most commonly diagnosed cancer in men and women worldwide, respectively. The American Cancer Society estimates that during 2016 in the USA around 430,000 individuals were diagnosed with one of these two types of cancers, and approximately 15% of them will die from the disease. In Europe, the rate of incidences and deaths are similar to those in the USA. Several different more or less successful diagnostic and therapeutic approaches have been developed and evaluated in order to tackle this issue and thereby decrease the death rates. By using nanoparticles as vehicles carrying both diagnostic and therapeutic molecular entities, individualized targeted theranostic nanomedicine has emerged as a promising option to increase the sensitivity and the specificity during diagnosis, as well as the likelihood of survival or prolonged survival after therapy. This article presents and discusses important and promising different kinds of nanoparticles, as well as imaging and therapy options, suitable for theranostic applications. The presentation of different nanoparticles and theranostic applications is quite general, but there is a special focus on prostate cancer. Some references and aspects regarding breast cancer are however also presented and discussed. Finally, the prostate cancer case is presented in more detail regarding diagnosis, staging, recurrence, metastases, and treatment options available today, followed by possible ways to move forward applying theranostics for both prostate and breast cancer based on promising experiments performed until today.

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Prostate Cancer Imaging and Therapy: Potential Role of Nanoparticles

Cited by 12 publications

References 73 publications

Elucidating Surface Ligand-Dependent Kinetic Enhancement of Proteolytic Activity at Surface-Modified Quantum Dots

Elucidating Surface Ligand-Dependent Kinetic Enhancement of Proteolytic Activity at Surface-Modified Quantum Dots

Prognostic and Theranostic Applications of Positron Emission Tomography for a Personalized Approach to Metastatic Castration-Resistant Prostate Cancer

Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications—Focus on Prostate and Breast Cancer

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