Prostate cancer in Asia: A collaborative report

Chen, Rui; Ren, Shancheng; Yiu, MK; Fai, Ng Chi; Cheng, W. S.; Ian, Lap Hong; Naito, Seiji; Matsuda, Tadashi; Kehinde, Elijah O.; Kural, Ali Rıza; Chiu, Jason Yichun; Umbas, Rainy; Wang, Qiang; Shi, Xiaolei; Zhou, Liqun; Huang, Jian; Huang, Yiran; Xie, Liping; Ma, Lulin; Chen, Yin; Xu, Danfeng; Xu, Kexin; Ye, Zhangqun; Liu, Chunxiao; Ye, Dingwei; Gao, Xin; Fu, Qiang; Hou, Jianquan; Yuan, Jianlin; He, Dalin; Pan, Tiejun; Ding, Qiang; Jin, Fang; Shi, Bibo; Wang, Gongxian; Liu, Xiuheng; Wang, Dongwen; Zhang, Shen; Kong, Xiangbo; Xu, Wanhai; Deng, Yaoliang; Xia, Haibo; Cohen, Arthur M.; Gao, Xu; Xu, Chuanliang; Sun, Yinghao

doi:10.1016/j.ajur.2014.08.007

Cited by 153 publications

(107 citation statements)

References 69 publications

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“…When compared with other Asian countries this pattern is similar to that found in China, Hong Kong and Taiwan [6]. Whether this is due to the late presentation or due to an unknown risk factor is debatable [8].…”

Section: Total 193supporting

confidence: 55%

“…In Asia prostate carcinoma is the sixth most frequent cancer in men [6]. Most prostate cancers (59.8%) in Sri Lanka still presents at the metastatic age similar to other South Asian countries and Indonesia [6,7]. Only 3% were screening detected.…”

Section: Total 193mentioning

confidence: 99%

“…According to the National Cancer Registry of Sri Lanka prostate carcinoma is the 9th most common cancer in Sri Lankan men [3]. In Asia prostate carcinoma is the sixth most frequent cancer in men [6]. Most prostate cancers (59.8%) in Sri Lanka still presents at the metastatic age similar to other South Asian countries and Indonesia [6,7].…”

Section: Total 193mentioning

confidence: 99%

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Clinicopathological profile of malignancies treated in a urology unit over a period of five years

et al. 2016

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ObjectiveTo identify the clinico-pathological profile of urological malignancies treated in the urology unit of a tertiary care hospital in Sri Lanka. Materials and methodsData related to all newly diagnosed and histologically confirmed malignancies in a urology unit of a tertiary care hospital in Sri Lanka were recorded prospectively over a ResultsThere were 386 prostate cancers, 193 bladder tumours, 173 renal tumours, 13 upper urinary tract carcinomas, eight penile cancers, seven testicular malignancies, one urethral carcinoma and two urachal carcinomas during the study period. Gleason score of 8 or more prostate cancers were seen in 164 (42.5%) patients. Metastases were present in 59.8% of patients with prostate cancer. Muscle invasive urothelial cancers constituted 31.4% patients with bladder carcinoma. Primary carcinoma-in-situ of the bladder was seen in only one patient. Average age at diagnosis of renal cell carcinoma was 56.9 years with a male to female ratio of 3.5:1.

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Section: Total 193supporting

confidence: 55%

Section: Total 193mentioning

confidence: 99%

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Clinicopathological profile of malignancies treated in a urology unit over a period of five years

et al. 2016

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“…For example, 100 and 250 mg/kg of genistein in the diet dramatically reduced metastasis of PC3-M cells in mice without affecting tumor volume (Lakshman et al, 2008). It is well established that men in Asian countries consume more soy products and have a lower risk of prostate cancer (Chen et al, 2014). A study of Japanese men in Los Angeles county found the risk of prostate cancer in immigrants increased to the levels of American born men, suggesting an environmental cause (Shimizu et al, 1991).…”

Section: Phytoandrogensmentioning

confidence: 99%

Phytosteroids beyond estrogens: Regulators of reproductive and endocrine function in natural products

Dean¹,

Murphy²,

Burdette³

2017

Molecular and Cellular Endocrinology

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Foods and botanical supplements can interfere with the endocrine system through the presence of phytosteroids – chemicals that interact with steroids receptors. Phytoestrogens are well studied, but compounds such as kaempferol, apigenin, genistein, ginsenoside Rf, and glycyrrhetinic acid have been shown to interact with non-estrogen nuclear receptors. These compounds can have agonist, antagonist, or mixed agonist/antagonist activity depending on compound, receptor, cell line or tissue, and concentration. Some phytosteroids have also been shown to inhibit steroid metabolizing enzymes, resulting in biological effects through altered endogenous steroid concentrations. An interesting example, compound A (4-[1-chloro-2-(methylamino)ethyl]phenyl acetate hydrochloride (1:1)) is a promising selective glucocorticoid receptor modulator (SGRM) based on a phytosteroid isolated from Salsola tuberculatiformis Botschantzev. Given that $6.9 billion of herbal supplements are sold each year, is clear that further identification and characterization of phytosteroids is needed to ensure the safe and effective use of botanical supplements.

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“…There are differences between Asian and Western populations 4 and the relationship between PSA level and PCa detection rate may thus differ between these populations as summarized in a recent review. 5 In this study, we aim to determine the characteristics of Chinese men undergoing initial prostate biopsy and evaluate the relationship between PSA level and the detection rate of PCa and HGPCa in a nationwide, multicenter biopsy cohort.…”

Section: Introductionmentioning

confidence: 99%

Prostate Specific Antigen and Prostate Cancer in Chinese Men Undergoing Initial Prostate Biopsies Compared with Western Cohorts

et al. 2017

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Purpose To determine characteristics of Chinese men undergoing initial prostate biopsy and to evaluate the relationship between PSA levels and PCa/HGPCa detection in a large Chinese multicenter cohort. Materials and Methods 13,904 Urology outpatients received biopsy for indications as following were included in this retrospective study: PSA levels of > 4.0 ng/mL or PSA levels of <4.0 ng/ml but with abnormal DRE results. The PSA measurements were performed in accordance with the standard procedures at the respective institutions. The type of assay used was documented and recalibrated to the WHO standard. Results The incidence of PCa and HGPCa were lower in the Chinese cohort than Western cohorts at any given PSA level. Around 25% of patients with PSA levels of 4.0-10.0 ng/mL were found to have PCa compared to approximately 40% in US clinical practice. Moreover, the risk curves were generally flatter than that of the Western cohorts, that is, risk did not increase as rapidly with higher PSA. Conclusions The relationship between PSA level and prostate cancer risk differs importantly between Chinese and Western populations, with overall lower risk in the Chinese cohort. Further research should explore whether environmental or genetic differences explain these findings or whether they result from unmeasured differences in screening or benign prostate disease. Caution is required for the implementation of prostate cancer clinical decision rules or prediction models to men in China, or other Asian countries with similar genetic and environmental backgrounds.

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Prostate cancer in Asia: A collaborative report

Cited by 153 publications

References 69 publications

Clinicopathological profile of malignancies treated in a urology unit over a period of five years

Clinicopathological profile of malignancies treated in a urology unit over a period of five years

Phytosteroids beyond estrogens: Regulators of reproductive and endocrine function in natural products

Prostate Specific Antigen and Prostate Cancer in Chinese Men Undergoing Initial Prostate Biopsies Compared with Western Cohorts

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