Prostate cancer metastasis to the mandible: case report

Parkins, GE; Kito, Go

doi:10.4314/eamj.v86i5.54200

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…Por ello, la mayoría de metástasis serán osteoblásticas; aunque también han sido notificadas en forma mixta, osteolítica, incluso sin evidencia radiológica. Al igual que otras neoplasias mandibulares, no es extraordinario el diagnóstico tras un dolor o parestesia-hipoestesia del nervio dentario inferior que no mejora tras tratamientos odontológicos [8][9][10][11] . No sólo han sido reportadas a nivel del cuerpo mandibular: también en ramas 12 , cóndilos 13 y glándulas parótidas con infiltración ósea 14 .…”

Section: Discussionunclassified

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Úbeda¹,

Monleón²,

Álvarez³

2023

Rev Osteoporos Metab Miner

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El cáncer de próstata es la lesión maligna no cutánea más frecuente en varones mayores de 70 años. El diagnóstico en estadíos avanzados de la enfermedad no es excepcional, mediante las lesiones metastásicas como debut. Las más características son óseas con comportamiento osteoblástico, infrecuentes en huesos maxilares. Por otro lado, la enfermedad ósea de Paget es una patología metabólica crónica por disfunción de osteoclastos. A nivel craneofacial la afectación característica es un aumento de tamaño, patrón en "copos de algodón" u osteoporosis circunscrita, siendo excepcional la localización única mandibular. Se presenta un caso de enfermedad ósea de Paget en hemimandíbula derecha sobre la que se desarrolla una metástasis por adenocarcinoma prostático.Palabras clave: enfermedad ósea de Paget, osteitis deformante, cáncer de próstata, metástasis, neoplasias orales. Metastatic prostate adeno-carcinoma and Paget's bone disease of the mandible SummaryProstate cancer is the most common non-cutaneous malignant lesion in males over 70 years of age. Diagnosis in advanced stages of the disease is not exceptional, through metastatic lesions as debut. The most characteristic of these lesions are osseous with osteoblastic behavior, uncommon in maxillary bones. On the other hand, Paget's disease is a chronic metabolic disorder attributed to osteoclast dysfunction. At the craniofacial level, the characteristic affectation is an increase in size, a "cotton flakes" pattern or circumscribed osteoporosis. The fact that this is only located in the mandible is exceptional. A case of Paget's disease of the right hemi-mandible bone is presented in which a metastasis is developed due to prostatic adenocarcinoma.

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Section: Discussionunclassified

Saber tibia

Úbeda¹,

Monleón²,

Álvarez³

2023

Rev Osteoporos Metab Miner

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“…Therefore, most metastases will be osteoblastic although they have also been reported in a mixed, osteolytic form, even without radiological evidence. As with other mandibular neoplasms, diagnosis is not unusual after pain or paresthesiahypoesthesia of the inferior dental nerve that does not improve after dental treatments [8][9][10][11] . They have not only been reported at mandibular level, but also in branches 12 , condyles 13 and parotid glands with bone infiltration 14 .…”

Section: Discussionmentioning

confidence: 99%

Adenocarcinoma de próstata metastásico y enfermedad ósea de Paget mandibular

Prol

Ruiz-Oslé

Malaxetxebarria

et al. 2018

Rev Osteoporos Metab Miner

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Prostate cancer is the most common non-cutaneous malignant lesion in males over 70 years of age. Diagnosis in advanced stages of the disease is not exceptional, through metastatic lesions as debut. The most characteristic of these lesions are osseous with osteoblastic behavior, uncommon in maxillary bones. On the other hand, Paget's disease is a chronic metabolic disorder attributed to osteoclast dysfunction. At the craniofacial level, the characteristic affectation is an increase in size, a "cotton flakes" pattern or circumscribed osteoporosis. The fact that this is only located in the mandible is exceptional. A case of Paget's disease of the right hemi-mandible bone is presented in which a metastasis is developed due to prostatic adenocarcinoma.

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“…A variant of PC3 which has a higher incidence of metastasis, PC3M, also forms osteolytic metastases (frequently within the mandible) after orthotopic and intracardiac injection [63,64]. Mandibular metastases in prostate cancer (and cancer in general) is an uncommon, but devastating event [65].…”

Section: Human Prostate Cancer Xenografts In Immunocompromised Micementioning

confidence: 99%

Review of Animal Models of Prostate Cancer Bone Metastasis

Simmons

Elshafae

Keller

et al. 2014

Veterinary Sciences

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Prostate cancer bone metastases are associated with a poor prognosis and are considered incurable. Insight into the formation and growth of prostate cancer bone metastasis is required for development of new imaging and therapeutic strategies to combat this devastating disease. Animal models are indispensable in investigating cancer pathogenesis and evaluating therapeutics. Multiple animal models of prostate cancer bone metastasis have been developed, but few effectively model prostatic neoplasms and osteoblastic bone metastases as they occur in men. This review discusses the animal models that have been developed to investigate prostate cancer bone metastasis, with a focus on canine models and also includes human xenograft and rodent models. Adult dogs spontaneously develop benign prostatic hyperplasia and prostate cancer with osteoblastic bone metastases. Large animal models, such as dogs, are needed to develop new molecular imaging tools and effective focal intraprostatic therapy. None of the available models fully reflect the metastatic disease seen in men, although the various models have provided important insight into the metastatic process. As additional models are developed and knowledge from the different models is combined, the molecular mechanisms of prostate cancer bone metastasis can be deciphered and targeted for development of novel therapies and molecular diagnostic imaging.

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Prostate cancer metastasis to the mandible: case report

Cited by 4 publications

References 11 publications

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Saber tibia

Adenocarcinoma de próstata metastásico y enfermedad ósea de Paget mandibular

Review of Animal Models of Prostate Cancer Bone Metastasis

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