Prostate cancer radiation dose response: results of the M. D. Anderson phase III randomized trial

Pollack, Alan; Zagars, Gunar K.; Starkschall, George; Antolak, John A.; Lee, John; Huang, Eugene; Eschenbach, Andrew C. von; Kuban, Deborah A.; Rosen, Isaac I.

doi:10.1016/s0360-3016(02)02829-8

Cited by 1,259 publications

(449 citation statements)

References 30 publications

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“…The adoption of conformal planning techniques has been shown to reduce rectal and bladder toxicity for a given prescribed dose, without reducing treatment efficacy (1). This has permitted dose escalation, with both improved biochemical control rates and acceptable, although increasing treatment-related morbidity (2). The use of intensity modulated radiotherapy (IMRT) may enable even greater sparing of organs at risk, making increased dose escalation a realistic option or permitting a further reduction in treatment related side effects.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of the Use of Bony Anatomy and Internal Markers for Offline Verification and an Evaluation of the Potential Benefit of Online and Offline Verification Protocols for Prostate Radiotherapy

McNair

Hansen

Parker

et al. 2008

International Journal of Radiation Oncology*Biology*Physics

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Section: Introductionmentioning

confidence: 99%

A Comparison of the Use of Bony Anatomy and Internal Markers for Offline Verification and an Evaluation of the Potential Benefit of Online and Offline Verification Protocols for Prostate Radiotherapy

McNair

Hansen

Parker

et al. 2008

International Journal of Radiation Oncology*Biology*Physics

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“…Perhaps the best example of this is in the management of prostate cancer where the development of 3D conformal radiotherapy has improved freedom from biochemical failure due to the ability to safely escalate radiation dose (1) . As doses are increased, the precision of dose delivery becomes crucial, so the treatment must be performed with great accuracy.…”

Section: Introductionmentioning

confidence: 99%

Target localization for post‐prostatectomy patients using CT and ultrasound image guidance

Paskalev

Feigenberg

Jacob

et al. 2005

J Applied Clin Med Phys

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We conducted a study comparing B‐mode acquisition and targeting (BAT) ultrasound alignments based on CT data in the postoperative setting. CT scans were obtained with a Primatom CT‐on‐rails on nine patients. Two CT scans were obtained each week, while setup error was minimized by BAT ultrasounds. For the first three patients, a direct comparison was performed. For the next six patients, a template based on the shifts from the week 1 CT during treatment was used for subsequent setup. Comparison of isocenter shifts between the BAT ultrasound and CT was made by the difference, absolute difference, and improvement (using CT alignments as the reference technique). A total of 90 image comparisons were made. The average interfraction motion was 3.2 mm in the lateral, 3.0 mm in the longitudinal, and 5.1 mm in the AP direction. The results suggest that the CT‐based ultrasound templates can improve the localization of the prostate bed when the initial displacements are greater than 4 mm. For initial displacements smaller than 4 mm, the technique neither improved nor worsened target localization. However, ultrasound alignments performed without the use of a template deteriorated patient positioning for two out of three patients, demonstrating that the use of a CT template was beneficial even at small initial displacements.PACS numbers: 87.53.‐j, 87.53.Kn, 87.53.Xd

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“…This encouraged the investigation of higher doses of radiation in attempts to establish the optimal dose that could be safely delivered. A randomized study at the MD Anderson Cancer Center [18] comparing doses of 70 Gy and 78 Gy in 305 men with T1-T3 prostate cancer showed a significant improvement in 'freedom from failure', including biochemical failure in the group of men presenting with a PSA > 10. In this higher-risk group, the freedom from failure rate was 62% for the 78-Gy arm vs. 43% for men who received 70 Gy (P = 0.01).…”

Section: Radiotherapymentioning

confidence: 99%

Management of locally advanced prostate cancer

Payne¹

2008

Asian J Androl

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The management of all stages of prostate cancer is an increasingly complex process and involves a variety of available treatments and many disciplines. Despite prostate-specific antigen (PSA) testing, the presentation of prostate cancer at a locally advanced stage is common in the UK, accounting for one-third of all new cases. There is no universally accepted definition of locally advanced prostate cancer; the term is loosely used to encompass a spectrum of disease profiles that show high-risk features. Men with high-risk prostate cancer generally have a significant risk of disease progression and cancer-related death if left untreated. High-risk patients, including those with locally advanced disease, present two specific challenges. There is a need for local control as well as a need to treat any microscopic metastases likely to be present but undetectable until disease progression. The optimal treatment approach will therefore often necessitate multiple modalities. The exact combinations, timing and intensity of treatment continue to be strongly debated. Management decisions should be made after all treatments have been discussed by a multidisciplinary team (including urologists, oncologists, radiologists, pathologists and nurse specialists) and after the balance of benefits and side effects of each therapy modality has been considered by the patient with regard to his own individual circumstances. This article reviews the current therapy options.

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Prostate cancer radiation dose response: results of the M. D. Anderson phase III randomized trial

Cited by 1,259 publications

References 30 publications

A Comparison of the Use of Bony Anatomy and Internal Markers for Offline Verification and an Evaluation of the Potential Benefit of Online and Offline Verification Protocols for Prostate Radiotherapy

A Comparison of the Use of Bony Anatomy and Internal Markers for Offline Verification and an Evaluation of the Potential Benefit of Online and Offline Verification Protocols for Prostate Radiotherapy

Target localization for post‐prostatectomy patients using CT and ultrasound image guidance

Management of locally advanced prostate cancer

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