Prostate cancer with metastases to the kidney: a rare manifestation of a common disease

Khan, Fahd; Mahmalji, Wasim; Sriprasad, Seshadri; Madaan, Sanjeev

doi:10.1136/bcr-2012-008388

Cited by 13 publications

(19 citation statements)

References 13 publications

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“…It has been assumed that metastatic infiltration presumably results from arterial tumor embolization since kidney has a highly vascular structure. [5] Interestingly, as far as we know in the literature renal metastasis from PCa always occurs at the left side. The underlying hematogenous or lymphogenous spread mechanisms are unknown therefore; further studies are needed in this issue.…”

Section: Discussionmentioning

confidence: 99%

“…In the report by Khan et al [5] , prostate adenocarcinoma and leftsided renal mass (5.5 cm in size) compatible to renal cell carcinoma with extra-renal extension was described in a 66-year-old male patient. Authors considered primary and metastatic renal cell carcinoma, lymphoma and benign lesions including angiomyolipoma or oncocytoma in the initial differential diagnosis but biopsy revealed prostatic origin of the mass lesion.…”

Section: Discussionmentioning

confidence: 99%

“…Survival rates reported in the literature range from 6 weeks to 18 months in patients with PCa and renal metastasis. [5,8] Our patient was followed up by monthly intervals. Our case is still alive 5 months after diagnosis of renal metastasis.…”

Section: Discussionmentioning

confidence: 99%

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Giant renal metastasis from prostate cancer mimicking renal cell carcinoma

Kurtul

Resim

Koçarslan

2018

Turkish Journal of Urology

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The most common sites for prostate cancer metastasis include bone, distant lymph nodes, liver and lungs. Renal metastasis of prostate cancer is a rarely seen pattern of invasion. In the current study, we described an 83-year-old male with a history of prostate cancer. He was admitted because of edema, hyperemia, warm and pain at left leg and inguinal region. In the further evaluation, a mass lesion at prostate region and conglomerate lymphadenopathy at left iliac vascular trajectory and a mass lesion at left kidney with heterogeneous contrast-enhancement were observed on contrast-enhanced magnetic resonance imaging and computerized tomography scan. Fine-needle aspiration biopsy was performed in the lesion with radiologically suspect renal cell carcinoma. By evaluating histopathological features and immunohistochemical staining of the tumor, we decided that the lesion was metastasis from prostate cancer.Keywords: Prostate cancer; renal metastasis; survival. ÖZProstat kanseri en sık kemik, uzak lenf düğümleri, karaciğer ve akciğere metastaz yapmaktadır. Prostat kanserinin renal metastazı oldukça nadir görülen bir yayılım şeklidir. Biz bu çalışmada, 83 yaşında prostat kanseri öyküsü olan bir vakayı sunduk. Hasta sol bacak ve kasık bölgesinde ödem, hiperemi, sıcaklık artışı ve ağrı nedeniyle başvurdu. Kontrastlı manyetik rezonans görüntüleme ve bilgisayarlı tomografi taramasında prostat lojunda kitle lezyonu ve sol iliyak vasküler bölgede konglomere lenfadenopati yanısıra, sol böbrekte heterojen kontrastlanan kitle lezyonu izlendi. Görüntüleme ile renal hücreli karsinom şüphesi olan lezyondan ince iğne aspirasyon biyopsisi yapıldı. Histopatolojik özellikler ve immunohistokimyasal boyamalar sonucunda tümörün prostat kanseri metastazı olduğuna karar verildi.Anahtar Kelimeler: Prostat kanser; renal metastaz; sağkalım.Cite this article as: Kurtul N, Resim S, Koçarslan S. Giant renal metastasis from prostate cancer mimicking renal cell carcinoma. Turk J Urol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Giant renal metastasis from prostate cancer mimicking renal cell carcinoma

Kurtul

Resim

Koçarslan

2018

Turkish Journal of Urology

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“…Prostate carcinoma comprises 15% of all men's cancers in developed countries and 4% of men's cancers in developing countries. Typically, prostate cancer metastasizes to the bone, lungs, and liver and locally invades the seminal vesicles, bladder, rectum, and regional lymph nodes (31). However, renal mass lesion should be considered in primary tumor metastasis, especially among the left size localized patients (32).…”

Section: Prostate Cancer and Kidneymentioning

confidence: 99%

Impact of cancers on the kidney function and structure; an ignored entity

Davoodi¹,

Bahadoram²,

Bahadoram³

et al. 2018

J Renal Inj Prev

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Important declines have been observed in urological cancer-related mortality in recent decades, mainly due to improvements in treatments of prostate cancer, less exposure to tobacco smoking as well as occupational carcinogens of kidney and bladder. However, because of global population ageing, age-related urinary tract cancers are expected to increase in the near future despite improved primary prevention, early detection and more efficient treatment. In this article, renal cell carcinoma (RCC), kidney transplantation, cancer and acute kidney injury (AKI), lung cancer and chronic kidney disease (CKD), breast cancer, prostate cancer, cervix cancer and brain cancer and their associations with kidney function and structure have been discussed. In conclusion, kidney and cancers have interaction with each other. Kidney carcinoma can be metastasizing to other organs as well as other cancer to kidney. Therefore, it is recommended to consider the potential effect of kidney functions and interaction with other cancers in each malignancy.

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“…Literature has shown diverse sites of possible metastases, these atypical metastatic locations being the ocular region, brain, respiratory tract, testes, mammary and parotid glands, the skin and the lymphatic system [4]. Some studies reported that 15% of men with PC might be affected by atypical metastases at diagnosis [5] [6].…”

Section: Introductionmentioning

confidence: 99%

Partial Nephrectomy as Treatment of an Atypical Metastasis from Prostate Cancer—A Case Report and Review of Literature

Sobrinho¹,

Diniz²,

Martins³

et al. 2018

OJU

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Background: Prostate cancer is the second most common type of cancer in man and the second in cancer-specific deaths in this population in the world. Most of the causes of death related to prostate cancer are due to its distant metastases, with the most common sites being: skeleton, distant lymph nodes, liver and lung. Renal metastasis is rare, and studies suggest infiltration due to arterial microembolization of the tumor. A key point in this scenario is the clinical suspicion of differential diagnoses, to offer the patient an effective therapy in such a specific case. Aim: To report a case of a patient with prostate cancer undergoing partial nephrectomy whose histopathological report revealed a metastatic lesion of that primary site. Case Presentation: 74 years old man, referred in May 2015 due to high PSA level and lumbago. PSA 323.11 ng/dl, rectal examination cT3a; biopsy was performed and histopathological study reported bilateral prostate adenocarcinoma, Gleason's score 8 (4 + 4). Patient's staging showed multiple secondary implants on skeletal scintigraphy. Tomography revealed solid exophytic lesion in the lower pole of the right kidney (4.7 × 3.6 cm); prostate without cleavage planes with seminal vesicles and pelvic node enlargement. Hormone therapy was initiated, PSA levels dropped to 9.51 ng/dl and total testosterone < 50 ng/dl. Partial nephrectomy was planned, initially by laparoscopy, but converted to laparotomy in December 2015. Procedure lasting 3 hours, minimal blood loss, no perioperative complications, discharged on the 3rd postoperative day. Histopathological report described undifferentiated malignant neoplasm, requiring immunohistochemistry that confirmed prostate adenocarcinoma. Patient remains hormone therapy, with no progression of the disease so far. Conclusion:How to cite this paper: Sobrinho, U

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Prostate cancer with metastases to the kidney: a rare manifestation of a common disease

Cited by 13 publications

References 13 publications

Giant renal metastasis from prostate cancer mimicking renal cell carcinoma

Giant renal metastasis from prostate cancer mimicking renal cell carcinoma

Impact of cancers on the kidney function and structure; an ignored entity

Partial Nephrectomy as Treatment of an Atypical Metastasis from Prostate Cancer—A Case Report and Review of Literature

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