Prostate Cancers Detected by Magnetic Resonance Imaging–Targeted Biopsies Have a Higher Percentage of Gleason Pattern 4 Component and Are Less Likely to Be Upgraded in Radical Prostatectomies

Zhao, Yani; Deng, Fang; Huang, Hongying; Lee, Peng; Lepor, Hebert; Rosenkrantz, Andrew B.; Taneja, Samir S.; Melamed, Jonathan; Zhou, Ming

doi:10.5858/arpa.2017-0410-oa

Cited by 9 publications

(5 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…86 Gordetsky et al 87 showed that aggregate GS (and cancer extent) for targeted biopsies better predicted tumor volume and extraprostatic extension than grading (and extent) in the worst single core. Zhao et al 88 found that targeted biopsy GS's were less likely to be upgraded at prostatectomy.…”

Section: Proposal and Votingmentioning

confidence: 99%

The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma

Leenders¹,

Kwast

Grignon

et al. 2020

American Journal of Surgical Pathology

Self Cite

403

311

View full text Add to dashboard Cite

Five years after the last prostatic carcinoma grading consensus conference of the International Society of Urological Pathology (ISUP), accrual of new data and modification of clinical practice require an update of current pathologic grading guidelines. This manuscript summarizes the proceedings of the ISUP consensus meeting for grading of prostatic carcinoma held in September 2019, in Nice, France. Topics brought to consensus included the following: (1) approaches to reporting of Gleason patterns 4 and 5 quantities, and minor/tertiary patterns, (2) an agreement to report the presence of invasive cribriform carcinoma, (3) an agreement to incorporate intraductal carcinoma into grading, and (4) individual versus aggregate grading of systematic and multiparametric magnetic resonance imaging-targeted biopsies. Finally, developments in the field of artificial intelligence in the grading of prostatic carcinoma and future research perspectives were discussed.

show abstract

Section: Proposal and Votingmentioning

confidence: 99%

The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma

Leenders¹,

Kwast

Grignon

et al. 2020

American Journal of Surgical Pathology

Self Cite

403

311

View full text Add to dashboard Cite

show abstract

“…Therefore, the preoperative GGG is a crucial variable included in PCa risk assessment tools, such as the D’Amico risk classification or cancer of the prostate risk assessment (CAPRA) score [ 28 , 29 , 30 ]. Nowadays, the absence of concordance between the biopsy and final histology reports represents one of the major concerns of PCa diagnosis and management due to the risk of mistreatment [ 37 , 38 ]. These aspects become particularly relevant in the context of AS, where a misinterpretation of GGG could defer the final curative treatment [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…Porcaro et al measured an upgrading rate at final pathology of 66.7% within 237 low-risk PCa patients who underwent RARP at a single tertiary referral center in Verona (vs. an upgrading rate of 74.4% in our population) [ 38 ]. Additionally, Zhao et al examined 243 PCa patients diagnosed with standard biopsy or MRI-targeted biopsy [ 37 ]. Upgrading was observed in 100 and 75% of GGG 1 patients who underwent standard biopsy or MRI-targeted biopsy, respectively [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Incidence and Predicting Factors of Histopathological Features at Robot-Assisted Radical Prostatectomy in the mpMRI Era: Results of a Single Tertiary Referral Center

et al. 2023

View full text Add to dashboard Cite

Background and Objectives: To describe the predictors of cribriform variant status and perineural invasion (PNI) in robot-assisted radical prostatectomy (RARP) histology. To define the rates of upgrading between biopsy specimens and final histology and their possible predictive factors in prostate cancer (PCa) patients undergoing RARP. Material and Methods: Within our institutional database, 265 PCa patients who underwent prostate biopsies and consecutive RARP at our center were enrolled (2018–2022). In the overall population, two independent multivariable logistic regression models (LRMs) predicting the presence of PNI or cribriform variant status at RARP were performed. In low- and intermediate-risk PCa patients according to D’Amico risk classification, three independent multivariable LRMs were fitted to predict upgrading. Results: Of all, 30.9% were low-risk, 18.9% were intermediate-risk and 50.2% were high-risk PCa patients. In the overall population, the rates of the cribriform variant and PNI at RARP were 55.8% and 71.1%, respectively. After multivariable LRMs predicting PNI, total tumor length in biopsy cores (>24 mm [OR: 2.37, p-value = 0.03], relative to <24 mm) was an independent predictor. After multivariable LRMs predicting cribriform variant status, PIRADS (3 [OR:15.37], 4 [OR: 13.57] or 5 [OR: 16.51] relative to PIRADS 2, all p = 0.01) and total tumor length in biopsy cores (>24 mm [OR: 2.47, p = 0.01], relative to <24 mm) were independent predicting factors. In low- and intermediate-risk PCa patients, the rate of upgrading was 74.4% and 78.0%, respectively. After multivariable LRMs predicting upgrading, PIRADS (PIRADS 3 [OR: 7.01], 4 [OR: 16.98] or 5 [OR: 20.96] relative to PIRADS 2, all p = 0.01) was an independent predicting factor. Conclusions: RARP represents a tailored and risk-adapted treatment strategy for PCa patients. The indication of RP progressively migrates to high-risk PCa after a pre-operative assessment. Specifically, the PIRADS score at mpMRI should guide the decision-making process of urologists for PCa patients.

show abstract

“…4 Further, target biopsy Gleason scores are less likely to be upgraded at prostatectomy compared with TRUS Gleason scores. 5 The PRECISION trial and the Canadian PRECISE trial, which compared MRI targeted biopsy vs TRUS biopsy in biopsy naïve men, demonstrated the benefit of MRI targeted biopsy in biopsy naïve patients, such that more clinically significant cancers were identified in the MRI targeted arm. 2,6 The ASIST trial also showed a reduction in upgrading at 2-year follow-up biopsies when patients had baseline MRI targeted biopsies.…”

Section: Introductionmentioning

confidence: 99%

Target prostate biopsies: how best to report in synoptic format?

Downes

Srigley

Loblaw

et al. 2021

CUAJ

View full text Add to dashboard Cite

Prostate Cancers Detected by Magnetic Resonance Imaging–Targeted Biopsies Have a Higher Percentage of Gleason Pattern 4 Component and Are Less Likely to Be Upgraded in Radical Prostatectomies

Cited by 9 publications

References 59 publications

The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma

The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma

Incidence and Predicting Factors of Histopathological Features at Robot-Assisted Radical Prostatectomy in the mpMRI Era: Results of a Single Tertiary Referral Center

Target prostate biopsies: how best to report in synoptic format?

Contact Info

Product

Resources

About