Prostate Carcinoma: Diffusion-weighted Imaging as Potential Alternative to Conventional MR and C-Choline PET/CT for Detection of Bone Metastases

Luboldt, Wolfgang; Küfer, R.; Blumstein, N. M.; Toussaint, T. L.; Kluge, Alexander; Seemann, M. D.; Luboldt, Hans-Joachim

doi:10.1148/radiol.2492080038

Cited by 110 publications

(50 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the addition of spectroscopy has also improved the specificity and diagnostic accuracy of MRI by adding a functional assessment through measuring metabolite levels such as choline, which is increased in PCa, and citrate, which is decreased [33]. In addition, with regard to the detection of distant metastasis, whole-body MR can assess nodal regions and appears equivalent to PET-CT in the detection of bone metastasis [34]. However, despite improved accuracy of detection with more contemporary imaging technologies, a negative scan cannot exclude the presence of distant disease.…”

Section: Imagingmentioning

confidence: 99%

Management of Biochemical Recurrence After Primary Treatment of Prostate Cancer: A Systematic Review of the Literature

et al. 2013

View full text Add to dashboard Cite

Context: Despite excellent cancer control with the treatment of localized prostate cancer (PCa), some men will experience a recurrence of disease. The optimal management of recurrent disease remains uncertain. Objective: To systematically review recent literature regarding management of biochemical recurrence after primary treatment for localized PCa. Evidence acquisition: A comprehensive systematic review of the literature was performed from 2000 to 2012 to identify articles pertaining to management after recurrent PCa. Search terms included prostate cancer recurrence, salvage therapy, radiorecurrent prostate cancer, post HIFU, post cryoablation, postradiation, and postprostatectomy salvage. Studies were selected according to Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines and required to provide a comprehensive description of primary and secondary treatments along with outcomes. Evidence synthesis: The data from 32 original publications were reviewed. The most common option for local salvage therapy after radical prostatectomy (RP) was radiation. Options for local salvage therapy after primary radiation included RP, brachytherapy, and cryotherapy. Different definitions of recurrence and risk profiles among patients make comparative assessment among salvage treatment modalities difficult. Triggers for intervention and factors predicting response to salvage therapy vary. Conclusions: Radiation therapy (RT) after RP can provide durable prostate-specific antigen (PSA) responses in a sizeable percentage of men, especially when given early (ie, PSA <1 ng/ml). Though a few studies suggest improvements in mortality, prospective randomized trials are needed and underway. The role of salvage treatment after RT is less clear.

show abstract

Section: Imagingmentioning

confidence: 99%

Management of Biochemical Recurrence After Primary Treatment of Prostate Cancer: A Systematic Review of the Literature

et al. 2013

View full text Add to dashboard Cite

show abstract

“…It is based on the molecular mobility of water. This mobility is determined by the interaction of water with intracellular elements, macromolecules, cell membranes, cell density and microstructural organization (7)(8)(9)(10).…”

Section: Discussionmentioning

confidence: 99%

“…Recently introduced parallel imaging techniques and the development of stronger gradients and multichannel coils have partially overcome these problems. These advances enable the technique to be widely applied for tumor evaluation in bones, the abdomen and the pelvis, and have led to the development of the whole-body DWI (8)(9)(10).…”

Section: Discussionmentioning

confidence: 99%

Metastatic meningioma: The role of whole‑body diffusion-weighted imaging

et al. 2011

View full text Add to dashboard Cite

Abstract. We report the case of a 74-year-old male patient with a completely resected anaplastic meningioma who developed multiple metastases two years later (subcutaneous tissue near the surgical area, cervical lymph nodes, lung, pleura and bones). The primary tumor and all of the metastases showed a significant restricted diffusion. Whole-body diffusion-weighted imaging (DWI) was performed for assessment of the metastases. This case demonstrated the usefulness of this technique in screening extracranial metastases in patients with malignant meningiomas.

show abstract

“…Furthermore, recent hardware and software advances have led to whole-body DWI assessment of the skeleton in very reasonable timeframes, and anatomic images can be fused to allow assessment of threat to spinal cord or nerve roots. Preliminary data suggest that DWI may surpass conventional T1W imaging and STIR for lesion detection ( Figure 5) and is equally as effective as 11 C choline (Luboldt et al, 2008).…”

Section: Mri For Assessment Of Bone Metastasesmentioning

confidence: 97%

Imaging metastatic bone disease from carcinoma of the prostate

2009

View full text Add to dashboard Cite

Imaging bone metastases from prostate cancer presents several challenges. The lesions are usually sclerotic and appear late on the conventional X-ray. Bone scintigraphy is the mainstay of lesion detection, but is often not suitable for assessment of treatment response, particularly because of a 'flare' phenomenon after therapy. Magnetic resonance imaging is increasingly used in assessment, and newer techniques allow quantitation. In addition to 18 F-fluorodeoxyglucose ( 18 FDG), newer PET isotopes are also showing promise in lesion detection and response assessment. This article reviews the available imaging modalities for evaluating prostatic bony metastases, and links them to the underlying pathological changes within bone lesions. British Journal of Cancer (2009) Prostate cancer is the second most common cancer in men, accounting for 1 in 9 of all new cancers, and with more than 670 000 new diagnoses annually worldwide. The metastatic spread is primarily in the skeleton (supporting the 'seed-and-soil' hypothesis described by Paget in 1889) in which lesions are often located in vertebra and ribs because of dissemination through Batson's venous plexus. The spread in bone also follows the distribution of adult red bone marrow, that is, skull, thorax, pelvis, spine, proximal long bones (Imbriaco et al, 1998;Scher, 2003), subsequently progressing to involve adjacent cortical bone. Preclinical models confirm that skeletal sites rich in cellular marrow with active turnover show increased cancer localisation (Schneider et al, 2005). Although predominantly osteoblastic, osteoclast activation also has an important role in the growth of sclerotic metastases in the bone. In a study of 68 men with prostatic bone metastases who underwent surgery for stabilisation of pathological fracture or impending fracture, most metastases were osteoblastic, but 29.1% had metastases that were osteolytic or mixed (Cheville et al,

show abstract

Prostate Carcinoma: Diffusion-weighted Imaging as Potential Alternative to Conventional MR and C-Choline PET/CT for Detection of Bone Metastases

Cited by 110 publications

References 27 publications

Management of Biochemical Recurrence After Primary Treatment of Prostate Cancer: A Systematic Review of the Literature

Management of Biochemical Recurrence After Primary Treatment of Prostate Cancer: A Systematic Review of the Literature

Metastatic meningioma: The role of whole‑body diffusion-weighted imaging

Imaging metastatic bone disease from carcinoma of the prostate

Contact Info

Product

Resources

About