Prostate Infiltration by Treg and Th17 Cells as an Immune Response to Propionibacterium acnes Infection in the Course of Benign Prostatic Hyperplasia and Prostate Cancer

Radej, Sebastian; Szewc, Monika; Maciejewski, Ryszard

doi:10.3390/ijms23168849

Cited by 18 publications

(4 citation statements)

References 103 publications

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“…It is believed that these changes could be linked to the severity of Cervical Intraepithelial Neoplasia (CIN), with an increase in Bacillus and Anaerococcus and a decrease in Gardnerella vaginalis potentially indicating a greater severity of the condition [ 36 ]. There are some studies suggesting that Propionibacterium acnes contributes to the development of several diseases in the prostate [ 37 ], gastric cancer [ 38 ], and ovarian cancer via regulating the hedgehog signaling pathway [ 32 ]. In this study, it was suggested that the genus level of Propionibacterium may be responsible for converting the cyst fluid environment to an environment with a lower concentration of iron.…”

Section: Discussionmentioning

confidence: 99%

Endogenous Microbacteria Can Contribute to Ovarian Carcinogenesis by Reducing Iron Concentration in Cysts: A Pilot Study

Kawahara,

Yamanaka,

Nishikawa

et al. 2024

Microorganisms

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Among epithelial ovarian cancer, clear cell carcinoma is common for chemo-resistance and high mortality. This cancer arises from benign ovarian endometrioma (OE), which is a high oxidative stress environment due to the cystic retention of menstrual blood produced during menstruation and the “iron” liberated from the cyst. There has been strong evidence that the iron concentration in OE decreases when they become cancerous. A decrease in iron concentration is a necessary condition for the formation of cancer. However, the mechanism of carcinogenesis is not yet clear. In the current study, the bacterial flora in endometriosis-associated ovarian cancer (EAOC), including clear cell carcinoma, and their origin, OE, were investigated using next-generation sequencing. The Shannon index in the genus level was significantly higher in EAOC than in OE fluids. Among several bacterial flora that were more abundant than benign chocolate cysts, a number of bacterial species that correlate very well with iron concentrations in the cysts were identified. These bacterial species are likely to be associated with decreased iron concentrations and cancer development.

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Section: Discussionmentioning

confidence: 99%

Endogenous Microbacteria Can Contribute to Ovarian Carcinogenesis by Reducing Iron Concentration in Cysts: A Pilot Study

Kawahara,

Yamanaka,

Nishikawa

et al. 2024

Microorganisms

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“…Indeed, it has been described that the presence of C. acnes in patients with prostate cancer correlates to a higher infiltration of regulatory T CD4(+), FoxP3(+) cells in prostatic tissues. Scientists discovered also that this infiltration correlates to the aggressiveness of the prostatic cancer in patients positive for C. acnes [13].…”

Section: Acnes Clinical Relevancementioning

confidence: 99%

Cutibacterium acnes Dysbiosis: Alternative Therapeutics for Clinical Application

Sá,

Fernandes,

Gestoso

et al. 2023

Applied Sciences

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Cutibacterium acnes (C. acnes) is a Gram-positive anaerobic facultative bacterium that is part of the human skin commensal microbiome. It colonizes various regions of the body, including the face, back, and chest. While typically a harmless commensal, under certain conditions, C. acnes can become pathogenic, leading to or promoting conditions such as acne vulgaris (AV), post-surgical infections, prostate cancer, and sarcoidosis. Current treatments for C. acnes infections often involve antibiotics, but the rise of antibiotic resistance has raised concerns. This review presents the virulence factors, clinical relevance, and current treatments of C. acnes, highlighting its association with AV, post-surgical infections, and other diseases. It also explores alternative innovative therapies such as phage therapy in development/research that are gaining prominence, with a growing focus on personalized medical approaches. To enhance C. acnes treatment while minimizing side effects and antibiotic prescription concerns, numerous clinical studies have been undertaken. These investigations span various pathological profiles and employ diverse strategies, such as utilizing bacterial extracts and compounds to restore healthy skin flora. The limitations and challenges of current and innovative treatments are also addressed, emphasizing the need for multidisciplinary strategies to combat C. acnes infections effectively.

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“…Propionibacterium acnes ( P. acnes ) is the most common microorganism in normal prostate tissues and is abundant in PCa tissues. It can activate the cGAS-STING pathway and induce the expression of IFN, which subsequently promotes PCa growth [ 128 , 129 ].…”

Section: Neoplasmsmentioning

confidence: 99%

The Role of cGAS-STING in Age-Related Diseases from Mechanisms to Therapies

et al. 2023

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With aging, the incidence of age-related diseases increases. Hence, age-related diseases are inevitable. However, the mechanisms by which aging leads to the onset and progression of age-related diseases remain unclear. It has been reported that inflammation is closely associated with age-related diseases and that the cGAS-STING signaling pathway, which can sense the aberrant presence of cytosolic DNA during aging and induce an inflammatory response, is an important mediator of inflammation in age-related diseases. With a better understanding of the structure and molecular biology of the cGAS-STING signaling axis, numerous selective inhibitors and agonists targeting the cGAS-STING pathway in human age-related diseases have been developed to modulate inflammatory responses. Here, we provide a narrative review of the activity of the cGAS-STING pathway in age-related diseases and discuss its general mechanisms in the onset and progression of agerelated diseases. In addition, we outline treatments targeting the cGAS-STING pathway, which may constitute a potential therapeutic alternative for age-related diseases.

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Prostate Infiltration by Treg and Th17 Cells as an Immune Response to Propionibacterium acnes Infection in the Course of Benign Prostatic Hyperplasia and Prostate Cancer

Cited by 18 publications

References 103 publications

Endogenous Microbacteria Can Contribute to Ovarian Carcinogenesis by Reducing Iron Concentration in Cysts: A Pilot Study

Endogenous Microbacteria Can Contribute to Ovarian Carcinogenesis by Reducing Iron Concentration in Cysts: A Pilot Study

Cutibacterium acnes Dysbiosis: Alternative Therapeutics for Clinical Application

The Role of cGAS-STING in Age-Related Diseases from Mechanisms to Therapies

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