Prostate-Specific Antigen-Based Prostate Cancer Screening: One for All or Individualized for Each Race? – A Narrative Review

Abstract

Prostate cancer (PCa) is the second most common cancer globally. However, significant disparities in incidence and mortality exist between countries, especially between Western and Asian regions. This review discusses the applicability of Western-based randomized controlled trials on prostate-specific antigen-based PCa screening in other regions such as Korea, where PCa is less frequently diagnosed but tends to present more aggressive features compared to Western countries. The paper also reviews major guidelines and landmark trials, emphasizing the importance of an individualized approach in the context of regional diversity in PCa incidence and mortality.