Prostate‐specific antigen nadir within 12 months of prostate cancer radiotherapy predicts metastasis and death

Abstract

Objective: The main goal of this study was to verify the influence of low birth weight (LBW) on the physical fitness of children aged 7–10 years. The comparisons were subsequently adjusted for chronological age, gender, physical activity (PA), and body composition. Methods: A total of 356 children of both genders born in Vitoria de Santo Antão (Northeast of Brazil) were divided into two groups according to their birth weight (LBW < 2.500 g, n = 100, and normal birth weight, NBW ≥ 3.000 g and ≤ 3.999 g, n = 256). Body composition measurements included body weight, height, body mass index, triceps, and subscapular skinfolds, and body fat percentage (%BF). PA was assessed by a questionnaire. Physical fitness was assessed by handgrip strength, muscle endurance, explosive power, flexibility, agility, maximal oxygen consumption (VO2max), and running speed. Results: LBW children were shorter, lighter, had lower fat‐free mass, muscle strength, and running speed but a higher VO2max than the NBW group. The differences in body weight (P = 0.507), height (P = 0.177), fat‐free mass (P = 0.374), and VO2max (P = 0.312) disappeared when adjusted for covariates. The differences in right and left handgrip strength (P < 0.01) and running speed (P < 0.01) remained significant even when controlled for age, gender, height, fat‐free mass, and PA. Conclusion: This combined analysis suggests that LBW alone can be not considered as a biological determinant of growth, body composition, or physical fitness in children, but is a predictor of muscle strength and running speed. Am. J. Hum. Biol., 2013. © 2012 Wiley Periodicals, Inc.

High-Dose Robotic Stereotactic Body Radiotherapy in the Treatment of Patients With Prostate Cancer

“…Although a longer follow-up is needed to confirm the results of SBRT in monotherapy or preboost modality for LpC, the data are encouraging and confirm the results obtained with HDR. 22,23 In another study, 19 a cohort of 38 patients with LpC, including 20 treated with SBRT monotherapy (38 Gy/4 fractions) and 18 with a post-EBRT boost (19 Gy/2 Fx) were described. The data observed were comparable to ours both in terms of toxicity and in terms of PSA control.…”

PSA Decrease During Combined-Modality Radiotherapy Predicts for Treatment Outcome

“…Although much effort has been placed on the importance of pretherapy PSA doubling time (1), less information is available regarding the possible importance of PSA response after therapy. Retrospective reviews from the Fox Chase Cancer Center (3,4) have demonstrated that posttherapy PSA can predict for long-term outcome reporting that the level of the PSA nadir was predictive of OS and metastatic free survival. Denham et al (5) recently reported on PSA response signatures.…”

“…Posttreatment PSA has also shown to be important. Several reports have discussed the prognostic information of posttreatment PSA, including nadir level (2)(3)(4), time to nadir, and PSA response signatures (5).…”

Interpretation of PSA levels after radical therapy for prostate cancer

“…The rates of distant metastases at 10 years were 4 per cent (PSA ≤2ng/ml) or 19 per cent (PSA >2ng/ml). 20 Horwitz et al (2005) studied this cohort postradiotherapy. Biochemical failure was defined as 2-3ng/ml greater than nPSA or two consecutive rises of at least 0.5ng/ml.…”