Prostate-Specific Membrane Antigen PET/Magnetic Resonance Imaging for the Planning of Salvage Radiotherapy in Patients with Prostate Cancer with Biochemical Recurrence After Radical Prostatectomy

Abstract

Prostate-specific membrane antigen (PSMA) PET/magnetic resonance (MR) imaging can help distinguish between patients with prostate cancer with locoregional recurrence and those with distant metastases, even at low prostate-specific antigen levels. PSMA PET/MR imaging may have advantages compared with PET/computed tomography for the detection of local recurrence and anatomic correlates to PET-positive lymph node and bone lesions. PSMA PET/MR imaging can help in making informed treatment decisions in patients with biochemical recurrence after radical prostatectomy. PSMA PET/MR imaging enables dose-escalated and metastases-directed salvage radiotherapy in patients with biochemical recurrence after radical prostatectomy.

Can 68Ga‐PSMA positron emission tomography and multiparametric MRI guide treatment for biochemical recurrence after radical prostatectomy?

“…Modern imaging methods such as mpMRI and 68 Ga‐PSMA PET/CT have increased diagnostic accuracy and may reduce overtreatment, especially in those with under‐staged metastatic disease on conventional imaging [18,19]. We demonstrate use of the combination of both radiology modalities to identify local recurrence, but more importantly, the decision to delay salvage RT in the presence of a rising postoperative PSA level and a negative MRI and PSMA PET/CT.…”

Incidental Detection of Asymptomatic Brain Metastases Due to Carcinoma Prostate in Ga-68 PSMA HBED-CC Positron Emission Tomography-Computed Tomography

“…[ 8 9 ] Ga-68 PSMA agents are proven to have a role in initial staging, response assessment, biochemical recurrence in castration-resistant prostate cancer, and radiotherapy planning. [ 10 11 12 13 ] In this case, solitary brain metastasis was found in the setting of normal PSA levels. So it was initially reported as PSMA-RADS 3C lesion.…”