Prostate-Specific Membrane Antigen–Targeted Radioguided Pelvic Lymph Node Dissection in Newly Diagnosed Prostate Cancer Patients with a Suspicion of Locoregional Lymph Node Metastases: The DETECT Trial

Schilham, Melline G.M.; Somford, Diederik M.; Küsters-Vandevelde, Heidi V.N.; Hermsen, Rick; van Basten, Jean Paul A.; Hoekstra, Robert J.; Scheenen, Tom W.J.; Gotthardt, Martin; Sedelaar, J.P. Michiel; Rijpkema, Mark

doi:10.2967/jnumed.123.266495

J Nucl Med

2024

DOI: 10.2967/jnumed.123.266495

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Prostate-Specific Membrane Antigen–Targeted Radioguided Pelvic Lymph Node Dissection in Newly Diagnosed Prostate Cancer Patients with a Suspicion of Locoregional Lymph Node Metastases: The DETECT Trial

Melline G.M. Schilham,

Diederik M. Somford,

Heidi V.N. Küsters-Vandevelde

et al.

Abstract: 18F-PSMA PET/CT-suggestive lesions in newly diagnosed PCa patients. The use of a radioactive PSMA tracer and a detection device (g-probe) during surgery helps in identifying LNs that were suggestive of PCa metastases on the 18 F-PSMA PET/CT before surgery and thus may improve the peroperative identification and removal of these LNs.

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Cited by 4 publications

References 25 publications

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Sterke correlatie tussen de intensiteit van prostaatkankerrecidieven op de PSMA PET/CT-scan en het intra-operatieve gammasonde signaal

Berrens,

Sorbi,

Donswijk

et al. 2024

Tijdschr Urol

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SamenvattingProstaatspecifiek membraan antigeen (PSMA) positronemissietomografie (PET) wordt gebruikt om prostaatkankerpatiënten met een biochemisch recidief te selecteren voor radiogeleide chirurgie (RGC). Tijdens RGC kan kankerweefsel worden geïdentificeerd na intraveneuze injectie van de PSMA-gerichte tracer [99mTc]Tc-PSMA-I&S. Het doel was om de correlatie te onderzoeken tussen de maximum standardized uptake value (SUVmax) op de preoperatieve PSMA PET/CT-scan en het intra-operatieve numerieke signaal (tellingen/seconde) gemeten met de Drop-In-gammasonde. Negenentwintig patiënten werden geïncludeerd in de prospectieve TRACE-studie (NCT03857113). Drieëndertig recidieven (29 nodaal, vier lokaal) werden preoperatief geïdentificeerd met een mediane SUVmax van 6,2 (interkwartielafstand [IKA] 4,2–9,7). Het mediane gammasondesignaal was 134 tellingen/s (IKA 81–220) in vivo en 109 (IKA 72–219) ex vivo, met een sterke correlatie met de SUVmax-waarden (ρs 0,728 en 0,763; p < 0,001, respectievelijk). Onze bevindingen tonen een directe relatie tussen de SUVmax-waarden op PSMA PET/CT-scan en het intra-operatieve signaal. De SUVmax-waarden kunnen dus worden gebruikt om patiënten te selecteren voor RGC.

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Sterke correlatie tussen de intensiteit van prostaatkankerrecidieven op de PSMA PET/CT-scan en het intra-operatieve gammasonde signaal

Berrens,

Sorbi,

Donswijk

et al. 2024

Tijdschr Urol

View full text Add to dashboard Cite

show abstract

Clinical Responses to Prostate-specific Membrane Antigen Radioguided Salvage Lymphadenectomy for Prostate Cancer Recurrence: Results from a Prospective Exploratory Trial

Weiner,

Ells,

Meyer

et al. 2024

European Urology Open Science

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Evolving Paradigms in Prostate Cancer: The Integral Role of Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography in Primary Staging and Therapeutic Decision-Making

Udovicich,

Jia,

Loblaw

et al. 2024

International Journal of Radiation Oncology*Biology*Physics

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Prostate-Specific Membrane Antigen–Targeted Radioguided Pelvic Lymph Node Dissection in Newly Diagnosed Prostate Cancer Patients with a Suspicion of Locoregional Lymph Node Metastases: The DETECT Trial

Cited by 4 publications

References 25 publications

Sterke correlatie tussen de intensiteit van prostaatkankerrecidieven op de PSMA PET/CT-scan en het intra-operatieve gammasonde signaal

Sterke correlatie tussen de intensiteit van prostaatkankerrecidieven op de PSMA PET/CT-scan en het intra-operatieve gammasonde signaal

Clinical Responses to Prostate-specific Membrane Antigen Radioguided Salvage Lymphadenectomy for Prostate Cancer Recurrence: Results from a Prospective Exploratory Trial

Evolving Paradigms in Prostate Cancer: The Integral Role of Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography in Primary Staging and Therapeutic Decision-Making

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