2021
DOI: 10.1021/acs.bioconjchem.1c00435
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Prostate-Specific Membrane Antigen-Targeted Turn-on Probe for Imaging Cargo Release in Prostate Cancer Cells

Abstract: The tunable nature of phosphoramidate linkers enables broad applicability as pH-triggered controlled-release platforms, particularly in the context of antibody- and small-molecule-drug conjugates (ADCs and SMDCs), where there remains a need for new linker technology. Herein, we explored in-depth the release of turn-on fluorogenic payloads from a homoserinyl-based phosphoramidate acid-cleavable linker. Kinetics of payload release from the scaffold was observed in buffers representing the pH conditions of system… Show more

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Cited by 10 publications
(2 citation statements)
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“…To evaluate whether CTT1298 conjugated to the dendrimer retained activity as an inhibitor of PSMA, the PSMA-IC 50 was evaluated using our previously pub- lished procedure. 41,42 The IC 50 of PD-CTT1298-Cy5 was still in nM range (20.26 nM), suggesting the retention of PSMA targeting ability upon dendrimer conjugation (Fig. 2C and S8 †).…”
Section: Synthesis Of Fluorescently Labelled Pd-ctt1298mentioning
confidence: 96%
See 1 more Smart Citation
“…To evaluate whether CTT1298 conjugated to the dendrimer retained activity as an inhibitor of PSMA, the PSMA-IC 50 was evaluated using our previously pub- lished procedure. 41,42 The IC 50 of PD-CTT1298-Cy5 was still in nM range (20.26 nM), suggesting the retention of PSMA targeting ability upon dendrimer conjugation (Fig. 2C and S8 †).…”
Section: Synthesis Of Fluorescently Labelled Pd-ctt1298mentioning
confidence: 96%
“…The routine determination of IC 50 , as most recently described in our laboratory, 41,42 for PD-CTT1298 was achieved using concentrations of 160, 80, 40, 20, and 10 nM. Results are presented as mean ± standard error of the mean (SE).…”
Section: Psma Ic 50 For Pd-ctt1298mentioning
confidence: 99%