Prostate Stroma: Physiology

Farnsworth, Wells E.

doi:10.1002/(sici)1097-0045(19990101)38:1<60::aid-pros8>3.3.co;2-v

Cited by 24 publications

(29 citation statements)

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“…This might cause an imbalance between cell proliferation and apoptosis that would favor the development of hyperplasia or cancer (Carson and Rittmaster, 2003;Farnsworth, 1999). Perhaps similar alterations caused by vasectomy can explain the results obtained in this study.…”

Section: Discussionsupporting

confidence: 67%

Repercussions of castration and vasectomy on the ductal system of the rat ventral prostate

Pereira

Martinez

et al. 2006

Cell Biology International

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Diseases, such as cancer and benign prostatic hyperplasia, are related to disruption of the mechanism regulating the balance between cell proliferation and apoptosis in prostatic cells. Since castration and vasectomy might alter that balance, this study evaluates the cell proliferation, apoptosis and height of the secretory epithelium of the ventral-prostate ductal system post-castration and vasectomy. Immunohistochemical (PCNA and Ki67), cytochemical (Fuelgen reaction) and morphometric investigation have been carried out. Cell proliferation indices decreased significantly in both regions of the ventral-prostate ductal system after castration compared to the sham-operated group. The apoptotic index increased significantly after 48 h, declining 7 days post-castration. The cell proliferation indices did not differ after 48 h significantly; however, they increased 7 days post-vasectomy in both regions. The apoptotic index did not differ significantly in either time post-vasectomy. Castration caused an imbalance in favor of apoptosis, whereas vasectomy caused an imbalance in favor of cell proliferation.

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Section: Discussionsupporting

confidence: 67%

Repercussions of castration and vasectomy on the ductal system of the rat ventral prostate

Pereira

Martinez

et al. 2006

Cell Biology International

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“…The other five are muscle-specific genes. This is not unexpected since the fibromuscular stroma surrounding prostatic glands is known to account for about half of the volume of the prostate [14]. …”

Section: Resultsmentioning

confidence: 99%

Congruence of tissue expression profiles from Gene Expression Atlas, SAGEmap and TissueInfo databases

2003

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Background: Extracting biological knowledge from large amounts of gene expression information deposited in public databases is a major challenge of the postgenomic era. Additional insights may be derived by data integration and cross-platform comparisons of expression profiles. However, database meta-analysis is complicated by differences in experimental technologies, data postprocessing, database formats, and inconsistent gene and sample annotation.

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“…These cells synthesize regulatory and structural components of the extracellular matrix to create a microenvironment that regulates the growth and functional differentiation of other cell types. These activities are regulated by androgens, which maintain the organ homeostasis (Farnsworth, 1999; Tuxhorn et al, 2001; Thomson et al, 2002). Prostatic SMC express androgen receptors (Prins et al, 1991), but the effects of androgens on the phenotype and behavior of these cells are poorly known, with often contradictory findings.…”

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confidence: 99%

Smooth Muscle Cell Behavior in the Ventral Prostate of Castrated Rats

Antonioli

Della-Colleta

Carvalho

2004

Journal of Andrology

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Smooth muscle cells (SMC) play roles in prostatic development and function. The cells also respond to tissue injury and hormonal variations, alternating between a fully differentiated and contractile phenotype and a dedifferentiated synthetic or secretory phenotype. However, the phenotypic changes in SMC after androgen deprivation have not yet been described. The ventral prostate of control and castrated rats was processed for routine histology, immunocytochemistry, reverse transcriptase polymerase chain reaction (RT-PCR), and scanning electron microscopy (SEM). The maintenance of SMC phenotype was confirmed by immunocytochemistry and by RT-PCR. Stereological analyses were done to define the relative and absolute volume of the SMC. SMC were elongated and flattened against the epithelium. After castration, the cells shortened concomitantly with pleating of the cell surface, leading to a spinous aspect. SEM showed that the smooth surface of SMC became progressively folded. Immunocytochemistry demonstrated both smooth muscle myosin heavy chain and smooth muscle alpha-actin in the prostatic SMC 21 days after castration, whereas RT-PCR amplified the message for smoothelin. Stereological analysis showed an increase in the relative volume of SMC in relation to the whole gland and the stroma. A decrease in the absolute volume of SMC occurred only within the first 7 days after castration and remained unchanged thereafter. The prostatic SMC are affected by the absence of androgens and there is a critical transition point during the first week in which the total volume occupied by SMC diminished. The remaining SMC showed a marked phenotypical change. These findings indicate that ventral prostate SMC maintain their differentiated phenotype after castration. The alterations in SMC behavior correlate with general stromal modifications taking place after castration.

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Prostate Stroma: Physiology

Cited by 24 publications

References 0 publications

Repercussions of castration and vasectomy on the ductal system of the rat ventral prostate

Repercussions of castration and vasectomy on the ductal system of the rat ventral prostate

Congruence of tissue expression profiles from Gene Expression Atlas, SAGEmap and TissueInfo databases

Smooth Muscle Cell Behavior in the Ventral Prostate of Castrated Rats

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