Prostatic capsular incision during radical prostatectomy has important oncological implications: a systematic review and meta‐analysis

Abstract

The absolute impact of CapI on oncological outcomes is currently unclear due to inconsistent definitions. However, the data implies an association between CapI and PSM and BCR. Reporting of possible areas of CapI on the operation note, or marking areas of concern on the specimen, are critical to assist CapI recognition by the pathologist. This article is protected by copyright. All rights reserved.

NeuroSAFE frozen section during robot‐assisted radical prostatectomy: peri‐operative and histopathological outcomes from the NeuroSAFE PROOF feasibility randomized controlled trial

“…Erectile dysfunction is a common and significant side effect of radical prostatectomy (RP). Nerve’sparing (NS) RP improves recovery of erectile function [1–3]; however, the quality of NS is often balanced against the oncological risks associated with positive surgical margins (PSMs) [4,5]. Clinical suspicion of extraprostatic extension of prostate cancer is a relative contraindication of NS RP [6] as it confers an increased risk of PSMs; however, accurate prediction of prostate cancer stage T3 (i.e.…”

Real‐time assessment of surgical margins during radical prostatectomy: a novel approach that uses fluorescence confocal microscopy for the evaluation of peri‐prostatic soft tissue

“…The surgeon may have also concerns about the safety of the dissection in an imaging‐safe area. Inadvertent incision into glandular tissue may occur and awareness of persistent benign prostate tissue at the margin of dissection is also important .…”

Unrecognized Pitfall When Doing Nerve-Sparing Surgery in Radical Prostatectomy

“…However, the experience and skill of surgeons as well as an approach such as open RP versus minimally invasive RP (laparoscopic RP and robot-assisted RP) are known to affect the PSM rate and location of PSM. 5,12 Therefore, the data on these points are important to precisely interpret the result. In addition, long-term studies on the impact of location of PSM in nerve-sparing RP are needed, not only for BCR but also for other outcomes such as metastasis-free survival, cancer-specific survival, and overall survival.…”