Prostatic Carcinoma: A Nutritional Disease? Conflicting Data From the Kingdom of Saudi Arabia

Hanash, Kamal A.; Al-Othaimeen, Abdulaziz I.; Kattan, Said; Lindstedt, E; Alzahrani, Hassan M.; Merdad, Talal; Peracha, Amjad; Kardar, Abdul Hafeez; Aslam, Muhammad; Al-Akkad, Arwa

doi:10.1016/s0022-5347(05)67030-9

Cited by 22 publications

(11 citation statements)

References 15 publications

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“…The pattern of diet habit in Saudi population has changed in recent decades, characterized by increased consumption of high saturated fat. 17 Substantial differences in the genetic breast cancer susceptibility would also be conceivable between our patient groups. The Arabian population is genetically unique.…”

Section: Discussionmentioning

confidence: 95%

Predominance of high-grade pathway in breast cancer development of Middle East women

et al. 2005

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Section: Discussionmentioning

confidence: 95%

Predominance of high-grade pathway in breast cancer development of Middle East women

et al. 2005

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“…However compared to the Western countries, the incidence in Arab men is lower [1][2][3][4][5] . In this study, the overall detection rate of prostate cancer in patients with elevated PSA levels was 27.4%.…”

Section: Discussionmentioning

confidence: 99%

Detection Rate and Clinical Pattern of Prostate Cancer in Kuwait: A Single-Center Experience

Arun

Abul²,

Mathew

2010

Med Princ Pract

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Objective: To determine the detection rate and clinical pattern of prostate cancer in Kuwait. Subjects and Methods: One hundred and fifty-three males suspected of having prostate cancer based on elevation of prostate-specific antigen (PSA) of more than 4 ng/ml underwent transrectal-ultrasound (TRUS)-guided needle biopsy of the prostate between January 2003 and January 2008; these formed the study group. Analysis of prostate cancer was based on age, prostate volume, PSA level and on finding any abnormality based on a combination of the diagnostic tools. Results: A diagnosis of prostate cancer was histologically confirmed in 42 (27.4%) patients. In those aged <55, 56–65, 66–75 and >76 years, the detection rates were 16.7, 17.6, 33.3 and 40.7%, respectively. In those with prostate volumes of >71, 51–70, 31–50 and <30 g, the detection rates were 18.2, 23.8, 30.8 and 42.9%, respectively. When the PSA levels were divided into groups of 4–10, 10–20, 20–100 and >100 ng/ml, the cancer detection rate was 11.8, 20.5, 47.1 and 83.3%, respectively. When 1, 2 and 3 of the 3 diagnostic tools (digital rectal examination, PSA, TRUS) were abnormal, the detection rate was 15.6, 27.9 and 80%, respectively. Conclusions: Our data showed that the prostate cancer rate differs according to the region and that the rate was low in our center. Higher PSA and higher number of diagnostic tools with abnormal findings were associated with a higher incidence of prostate cancer.

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“…40 However, this is changing owing to the abrupt rise in purchasing power and the diet is increasingly similar to that in the West. 41,42 Therefore, the low levels of serum IGF-1 and IGFBP-3 found in the Arabs in this study is unlikely to be due to lower energy and/or protein deprivation.…”

Section: Discussionmentioning

confidence: 64%

Putative role of serum insulin-like growth factor–1 (IGF-1) and IGF binding protein-3 (IGFBP-3) levels in the development of prostate cancer in Arab men

Kehinde

Akanji

Mojiminiyi

et al. 2005

Prostate Cancer Prostatic Dis

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Introduction: The incidence of clinical prostate cancer in the Arab population is among the lowest in the world. High serum IGF-1 level has been implicated as a possible risk factor for the development of prostate cancer in Caucasians. The purpose of this study was to determine serum IGF-1 and IGFBP-3 levels in healthy Arab men and in Arab men with newly diagnosed benign prostatic hyperplasia (BPH) and prostate cancer, and to compare these values with values reported in Caucasians. Patients and Methods: Subjects were recruited in two groups: (a) indigenous, healthy Arab men aged 15-90 y (n ¼ 383); (b) Arab men with newly diagnosed prostate cancer (n ¼ 30) or BPH (n ¼ 40). Blood was obtained from fasting patients and volunteers, between 8:00 a.m. and 12:00 noon. The serum concentrations of IGF-1 and IGFBP-3 were determined using Immunoradiometric assay (IRMA) kits. Results: As in Caucasians, serum IGF-1 and IGFBP-3 levels declined with age in Arab men. The mean7s.d. of serum IGF-1 levels in healthy Arab men in the age group 15-20, 51-60, 61-70 y were lower (376.27153.2, 134.97105.7 and 89.6748.4 ng/ml, respectively), compared to values reported for similarly aged Caucasians. Arab men with newly diagnosed prostate cancer had significantly higher serum IGF-1 level (Po0.01) and lower IGFBP-3 levels (Po0.01) compared to age-matched Arabs without the disease. Conclusions: Arab men have lower serum IGF-1 levels compared to Caucasians and this may be an important factor in the explanation of the low incidence of prostate cancer in the Arab population.

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Prostatic Carcinoma: A Nutritional Disease? Conflicting Data From the Kingdom of Saudi Arabia

Abstract: The incidence of prostatic carcinoma in the Kingdom of Saudi Arabia is low despite a high saturated fat diet in recent years. This finding contradicts most western clinical studies, which indicate a positive association of a high fat diet with prostatic carcinoma.

Cited by 22 publications

References 15 publications

Predominance of high-grade pathway in breast cancer development of Middle East women

Predominance of high-grade pathway in breast cancer development of Middle East women

Detection Rate and Clinical Pattern of Prostate Cancer in Kuwait: A Single-Center Experience

Putative role of serum insulin-like growth factor–1 (IGF-1) and IGF binding protein-3 (IGFBP-3) levels in the development of prostate cancer in Arab men

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