Prostatic mucinous adenocarcinoma

Mucin-producing Tumors and Tumor-like Lesions Involving the Prostate

“…These classifications include: mucinous carcinoma (> 25% extracellular mucinous component), primary signet ring cell carcinoma (< 25% extracellular mucinous component, >25% signet ring cell component), and mucinous carcinoma with signet ring cells (> 25 extracellular mucinous component, but <25% signet ring cell component). 2,[5][6][7]9,20,[23][24][25]31,33,124,125 However, treatments including radiotherapy and androgen ablation have shown success, and these tumors may actually be frequently hormonally sensitive. The prognosis of signet ring cell adenocarcinoma was even worse with a 27.3% 3-year survival rate; none of the 17 cases survived up to 5 years, and interestingly and somewhat paradoxically, the prognosis of mucinous carcinoma with signet ring cells had a dire 3-year survival rate of 16.7%.…”

“…50,60,128 However, an investigation by Torbenson et al 133 found immunoreactivity for PSA in 12 of 12 prostatic adenocarcinomas with a signet ring cell component, but PSA was also immunoreactive in 3 of 6 urinary bladder carcinomas and 2 of 7 gastric cancers, both with signet ring cells, indicating some difficulty in distinguishing between these entities on the basis of immunohistochemical analysis for PSA. 5,136 Additional tumors within the differential diagnosis that may have mucinous differentiation include Cowper gland carcinoma and urethral adenocarcinoma. 30,133 Epstein et al 124 investigated 15 urinary bladder adenocarcinomas and 9 urinary bladder tumors with mixed glandular and transitional features and found that of the 11 urinary bladder adenocarcinomas in men, 3 were immunoreactive PSAP, and of the 5 urinary bladder tumors with mixed glandular and transitional features in men, 1 was immunoreactive for PSAP.…”

“…Therefore, caution should also be exercised while investigating the potential diagnosis of a rare primary signet ring cell adenocarcinoma of the urinary bladder in male patients with direct extension into the prostate, which may be immunoreactive for PSA and PAP as well. 5 Mucin-producing urothelial-type adenocarcinoma of the prostate is very rare and may arise from the prostatic urethra or prostatic ducts (in a background of urothelial metaplasia), possibly from urethritis glandularis or glandular metaplasia with malignant transformation and is analogous to adenocarcinoma arising from the urinary bladder and may also originate from periurethral structures such as Cowper (bulbourethral) or Littre glands. None of the urinary bladder adenocarcinomas or urinary bladder tumors with glandular features in either men or women was immunoreactive for PSA.…”

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] The incidence of primary mucinous adenocarcinoma of the prostate has been found to be between 0.21% and 0.43% of all prostatic carcinomas (Table 1), and Boyd is credited with the first description in 1882. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] The incidence of primary mucinous adenocarcinoma of the prostate has been found to be between 0.21% and 0.43% of all prostatic carcinomas (Table 1), and Boyd is credited with the first description in 1882.…”

Mucinous adenocarcinoma of the prostate: A case report

“…Some authors suggest that a gleason score of 8 is to be assigned, whereas others recommend ignoring mucin and grading tumor based on the underlying architectural pattern 7. Patient with mucinous prostatic adenocarcinoma have increased PSA with advanced disease and occasionally followed with widespread metastasis 1,4,8,9 , while others authors reported excellent outcome with radical prostatectomy 5,10 .…”