Prostatic Specific Antigen

Tranilast inhibits hormone refractory prostate cancer cell proliferation and suppresses transforming growth factor β1‐associated osteoblastic changes

“…The clinical study in this article is the first pilot trial of tranilast use for treatment of patients with cancer. PSA is a very sensitive, specific, and meaningful serum marker for tumors of prostate origin in all clinical situations and is correlated to clinical condition [37]. Generally, once prostate cancer becomes advanced HRPC after several rounds of salvage therapy, the general condition of the patient becomes worse with continuous PSA progression without temporary recovery.…”

In vivo imaging of tumors with protease-activated near-infrared fluorescent probes

“…The proposed imaging strategy also has potential to interrogate tissues for specific enzymes by attaching the fluorochrome to the carrier backbone through specific linkers. Such strategies could be used to image specific tumor-associated proteases such as prostate specific antigen 51 and matrix metalloproteases (MMP) 17,52 , assess anti-MMP-directed therapy at a molecular level, or probe for key enzymes involved in the metastatic cascade 53,54 . It is also conceivable to construct biocompatible quenched probes that contain different fluorochromes with different enzyme specificities to allow for multichannel NIRF imaging.…”

Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis.

“…The catalytic mechanisms of serine proteases and the family of serine esterases to which PPT belongs are highly similar. These similarities are underscored by the observations that the serine proteases have been reported to have esterase activity (38,39) and that certain thioesterases have been reported to have protease activity (40). Thus, the observed correlation of lipofuscin induction and increases in endogenous or artificial serine protease inhibitors may be due to the inhibition of PPT, and it is possible that PPT also has protease activity.…”