Prostatic stromal sarcoma: Case report and review of the literature

Abstract

We report a case of a 65-year-old man with rare prostatic stromal sarcoma in which suprapubital radical prostatectomy was performed, but neither chemotherapy nor radiation therapy were administered before or after the operation. The well-circumscribed tumor, measuring 5 cm in diameter, showed a homogeneous white grayish cut surface with a hard consistency. Histopathologically, the tumor consisted mainly of medium-sized rounded cells with a sarcomatous and epithelioid appearance intermingled with collagen fiber. Hyalinized foci were also noted in the tumor. Immunohistochemistry revealed that the tumor cells were diffusely positive for vimentin and focally positive for progesterone receptor and CD34, but not for EMA, cytokeratin or estrogen receptor. No recurrence or distant metastasis of the tumor has occurred in 8 years of follow up. The tumor was diagnosed as prostatic stromal sarcoma (PSS) showing epithelioid differentiation and of a progesterone-dependent nature. Possible favorable nature of the PSS might be expected after complete resection.

MRI Appearance of Prostatic Stromal Sarcoma in a Young Adult

“…Leiomyosarcoma is the most common histological subtype of prostate sarcoma seen in adults (6). Prostate stromal sarcoma is rarer with fewer than 30 documented cases (1)(2)(3)(4)(5)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Most patients with prostatic sarcoma, including PSS, present with symptoms of urethral obstruction (1-3, 5, 6), as in the present case.…”

MRI findings of prostate stromal tumour of uncertain malignant potential: a case report

“…Occasionally, it may be difficult to differentiate sarcoma from STUMP, especially when based only on histology [5,[7][8]. There are reports of STUMP tumours that appeared histologically benign; however, based on surgical specimen features, a sarcoma was diagnosed.…”

Treatment of prostatic stromal sarcoma with robot-assisted laparoscopic radical prostatectomy in a young adult: A case report

“…PSS is an extremely rare subtype of prostate sarcoma with <30 documented cases (2,3,5,6). The majority of these lesions present in the sixth and seventh decades of life, and the majority of patients present with symptoms of urethral obstruction, such as in the present case (2,3,5,6). Patients with PSS usually have a PSA level within the normal range.…”

“…In 1998, Gaudin et al (1) classified PSS into two categories: Prostatic stromal proliferation of uncertain malignant potential and PSS. The etiology and pathogenesis of PSS is currently unknown, and no confirmed risk factors have been identified (1,2). As the majority of patients present with obstructive urinary symptoms, the diagnosis of prostatic stromal sarcoma is frequently made following open prostatectomy or transurethral resection of the prostate (3).…”