Prostatic Tissue Ablation by Injection: A Literature Review

Plante, Mark; Folsom, Jeffrey B.; Zvara, Peter

doi:10.1097/01.ju.0000121690.37499.1c

Cited by 42 publications

(63 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a delivery system, adenovirus vector has multiple advantages [17]: (1) ease of genetic manipulation, (2) high transduction efficiency into nondividing cells, (3) ease of high titer production, (4) copious gene expression in vitro, and (5) storage stability. Our previous work established that Ad-decorin can induce a high expression of decorin in glomerular mesangial cells in vitro [15].…”

Section: Discussionmentioning

confidence: 99%

Adenovirus-Mediated Decorin Gene Transfection Has Therapeutic Effects in a Streptozocin-Induced Diabetic Rat Model

Zhang

Zheng

et al. 2010

Nephron Exp Nephrol

View full text Add to dashboard Cite

Background/Aims: Transforming growth factor β₁ (TGF-β₁) is a key mediator in diabeticnephropathy (DN). Decorin, a natural inhibitor of TGF-β₁, may have healing properties. We investigated whether overexpression of decorin in the kidneys of streptozocin (STZ)-induced diabetic rats improved pathogenic and clinical changes of DN. Methods: Forty-eight Sprague-Dawley rats were evenly divided into 4 groups: STZ-induced diabetic rats (diabetic-control), decorin adenovirus vector (Ad)-treated STZ rats (Ad-decorin), and Ad-lacZ-treated STZ rats (Ad-lacZ), and vehicle control (PBS-control). At 10, 12, and 16 weeks after STZ treatment, we measured urinary albumin excretion (UAE), and immunolabeled type IV collagen in histological samples of rat kidney. We also measured kidney decorin and TGF-β₁ levels by reverse transcription polymerase chain reaction and Western blot. Phosphorylated Smad2,3 (p-Smad2,3) was also measured by Western blot. Results: Decorin gene transfection mediated by a recombinant adenovirus has antirenal fibrosis and anti-albuminuria effects in STZ-induced diabetic rats. TGF-β₁ mRNA and protein expression in diabetic kidney were reduced 2 weeks after Ad-decorin injection. Conclusion: The renal protective effect of decorin in diabetic rats is at least partly due to the downregulation of the TGF-β₁/Smad signaling pathway. Ad-decorin shows potential as a therapeutic for human DN.

show abstract

Section: Discussionmentioning

confidence: 99%

Adenovirus-Mediated Decorin Gene Transfection Has Therapeutic Effects in a Streptozocin-Induced Diabetic Rat Model

Zhang

Zheng

et al. 2010

Nephron Exp Nephrol

View full text Add to dashboard Cite

show abstract

“…Currently, transurethral prostatectomy is accepted as the gold standard for surgical intervention. However, for those patients at high operative risk or those unsuitable for surgery, various minimally invasive treatment modalities have emerged, including laser therapy, cryoablation, and intraprostatic injection of ethanol (5)(6)(7)(8)(9)(10)(11)(12). However, the results of these new modalities are not superior to those of transurethral prostatectomy, and they have their own limitations.…”

Section: Benign Prostate Hyperplasia (Bph)mentioning

confidence: 99%

The Effect of Transarterial Prostate Embolization in Hormone-induced Benign Prostatic Hyperplasia in Dogs: A Pilot Study

Jeon

Won

Lee³

et al. 2009

Journal of Vascular and Interventional Radiology

View full text Add to dashboard Cite

“…The first report of intraprostatic injection is attributed to Stoll in 1877 for the treatment of a prostatic abscess [39]. Since then, many reports have been published, mainly for the treatment of BPH in high-risk surgical candidates.…”

Section: Ethanol Ablationmentioning

confidence: 99%

Minimally invasive techniques for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia: An update

Leitão¹,

Haleblian²,

Albala

2007

Curr Bladder Dysfunct Rep

View full text Add to dashboard Cite

Benign prostatic hyperplasia (BPH) primarily affects middle-aged and elderly men. Consequently, medical and surgical treatments for this condition are some of the most common therapies administered in medical practice. Many minimally invasive techniques for the treatment of BPH have been introduced over the past several years to achieve comparable efficacy without the morbidity and mortality associated with transurethral resection of the prostate (TURP), the current gold standard for the surgical management of BPH. Many procedures have not sustained satisfactory results over time, whereas others have been reported as possible alternatives, in selected cases, to TURP. It may not be a simple question of comparative efficacy with TURP for these less invasive treatments, but rather a question of whether lower complication and side-effect rates are a suitable tradeoff for somewhat reduced symptom relief and possibly a need for future retreatment. This article reviews current minimally invasive therapies, addressing methods of tissue ablation, short-and long-term results, and comparisons with TURP.

show abstract

Prostatic Tissue Ablation by Injection: A Literature Review

Abstract: Examined for more than a century, the potential for using injectables for prostatic tissue ablation remains significant. More systematic laboratory research and clinical trials, currently ongoing, need to be completed.

Cited by 42 publications

References 52 publications

Adenovirus-Mediated Decorin Gene Transfection Has Therapeutic Effects in a Streptozocin-Induced Diabetic Rat Model

Adenovirus-Mediated Decorin Gene Transfection Has Therapeutic Effects in a Streptozocin-Induced Diabetic Rat Model

The Effect of Transarterial Prostate Embolization in Hormone-induced Benign Prostatic Hyperplasia in Dogs: A Pilot Study

Minimally invasive techniques for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia: An update

Contact Info

Product

Resources

About