Prostatodynia—Physiological Characteristics and Rational Management with Muscle Relaxants

Osborn, D. E.; George, N. J. R.; Rao, Prasanna N; Barnard, R.; Reading, Clive; Marklow, C.; Blacklock, N. J.

doi:10.1111/j.1464-410x.1981.tb03275.x

Cited by 82 publications

(39 citation statements)

References 6 publications

(4 reference statements)

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“…Some studies [5, 6] ]had addressed the urodynamic findings of these patients. Barbalias [7]studied a group of patients having prostatodynia and found that the Q max ranged from 4 to 33 ml/s, with a mean of 10.5 ml/s.…”

Section: Discussionmentioning

confidence: 99%

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Quantitative and Qualitative Assessment of Flowmetrograms in Patients with Prostatodynia

Ghobish

2000

European Urology

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Section: Discussionmentioning

confidence: 99%

“…Some urodynamic studies were undertaken in these patients [5, 6, 7, 8]. Discrepancies exist about the prevalence of urodynamic abnormalities.…”

Section: Introductionmentioning

confidence: 99%

Quantitative and Qualitative Assessment of Flowmetrograms in Patients with Prostatodynia

Ghobish

2000

European Urology

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“…Osborn et al [9] reported that a combination of phenoxybenzamine, baclofen and placebo is very effective in relieving the symptoms of chronic prostatitis (CP). This study Fig.…”

Section: A Brief Review Of Clinical Trialsmentioning

confidence: 99%

Role of alpha blocker therapy in chronic prostatitis/chronic pelvic pain syndrome: limited options with promising results

Singh

Sinha

2008

Indian J Surg

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Chronic prostatitis / chronic pelvic pain syndrome (NIH-type II and type III prostatitis) are common cause of chronic pelvic pain. The exact etiology of these entities are unknown. They are associated with varying degree of voiding and sexual dysfunction. Consensus regarding treatment of these pain syndromes is lacking. Review of literature suggest a therapeutic role of alpha adrenergic receptor blockers in the management of NIH-type II and type III prostatitis. A trial of alpha-blocker is reasonably inexpensive and appropriate for most patients suffering from NIH-type III prostatitis and NIH-type II prostatitis. A general consensus is that if a patient agrees to a trial of alphablocker therapy which subsequently shows a good response then it should be continued for at least 6 months for a proper therapeutic effect. This review analyses the role of alphablockers in this disease/syndrome; discusses the possible mechanism of action through which these drugs provide relief and also highlights some of the important trials which have paved way for this particular treatment option in this intriguing disease /syndrome. Keywords Prostate . . Pain . . Adrenergic alpha antagonists . . Chronic prostatitis with chronic pelvic pain syndrome.

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“…Patients with CPPS are thought to have an altered sensation of the perineum in comparison to control patients without CP/CPPS. The mechanism of this 'altered' innervations is poorly understood and is thought to be related to reflex sympathetic dystrophy of the perineum and pelvic floor [43][44][45].…”

Section: C Neurologicalmentioning

confidence: 99%

Chronic Prostatitis/Chronic Pelvic Pain Syndrome

2008

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Prostatodynia—Physiological Characteristics and Rational Management with Muscle Relaxants

Abstract: Patients with a clinical diagnosis of prostatodynia were evaluated by bacteriological, urodynamic and psychological means. In a prospective study 27 patients were entered on a trial of phenoxybenzamine, baclofen and placebo. A 50% symptomatic response was reported with phenoxybenzamine.

Cited by 82 publications

References 6 publications

Quantitative and Qualitative Assessment of Flowmetrograms in Patients with Prostatodynia

Quantitative and Qualitative Assessment of Flowmetrograms in Patients with Prostatodynia

Role of alpha blocker therapy in chronic prostatitis/chronic pelvic pain syndrome: limited options with promising results

Chronic Prostatitis/Chronic Pelvic Pain Syndrome

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