Prosthetic joint infections in the elderly

Angelis, Giulia De; Mutters, Nico T.; Minkley, Lena; Holderried, Friederike; Tacconelli, Evelina

doi:10.1007/s15010-015-0806-6

Cited by 20 publications

(13 citation statements)

References 67 publications

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“…This is clearly important as increased bone contact without increased resorption, combined with reduced risk of infection, would be the optimal implant surface. A major concern for implant technologies is infection as rapid failure of implants can result283839. This worry is in tune with world-wide concerns of growing antibiotic resistance and even the possibility of the post-antibiotic era.…”

Section: Discussionmentioning

confidence: 99%

“…We show that the nanowire TiO 2 substrates support growth of osteogenic cells without stimulating a further associated osteoclast response. At the same time bacterial viability of a pathogen (Pseudomonas Aeruginosa) commonly involved to medical device-associated infections2728, is reduced on the optimal nanotopography for bone marrow (BM) cell growth, providing a good candidate surface for new orthopaedic and dental implants.…”

mentioning

confidence: 99%

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Osteogenic and bactericidal surfaces from hydrothermal titania nanowires on titanium substrates

Tsimbouri

Fisher

Holloway

et al. 2016

Sci Rep

104

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Nanotopographical cues on Ti have been shown to elicit different cell responses such as cell differentiation and selective growth. Bone remodelling is a constant process requiring specific cues for optimal bone growth and implant fixation. Moreover, biofilm formation and the resulting infection on surgical implants is a major issue. Our aim is to identify nanopatterns on Ti surfaces that would be optimal for both bone remodelling and for reducing risk of bacterial infection. Primary human osteoblast/osteoclast co-cultures were seeded onto Ti substrates with TiO2 nanowires grown under alkaline conditions at 240 °C for different times (2, 2.5 or 3 h). Cell growth and behaviour was assessed by scanning electron microscopy (SEM), immunofluorescence microscopy, histochemistry and quantitative RT-PCR methods. Bacterial colonisation of the nanowire surfaces was also assessed by confocal microscopy and SEM. From the three surfaces tested the 2 h nanowire surface supported osteoblast and to a lesser extent osteoclast growth and differentiation. At the same time bacterial viability was reduced. Hence the 2 h surface provided optimal bone remodeling in vitro conditions while reducing infection risk, making it a favourable candidate for future implant surfaces.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Osteogenic and bactericidal surfaces from hydrothermal titania nanowires on titanium substrates

Tsimbouri

Fisher

Holloway

et al. 2016

Sci Rep

104

View full text Add to dashboard Cite

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“…Pathogenic microorganisms easily produce biofilms on surfaces such as catheters or surgical implants [7]. Unfortunately, older people and patients diagnosed with rheumatoid arthritis, obesity, or diabetes are particularly vulnerable to the occurrence of post-operative infections after prosthesis implantation [8].…”

Section: Introductionmentioning

confidence: 99%

Serine Protease Inhibitors—New Molecules for Modification of Polymeric Biomaterials

et al. 2020

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Three serine protease inhibitors (AEBSF, soy inhibitor, α1-antitrypsin) were covalently immobilized on the surface of three polymer prostheses with the optimized method. The immobilization efficiency ranged from 11 to 51%, depending on the chosen inhibitor and biomaterial. The highest activity for all inhibitors was observed in the case of immobilization on the surface of the polyester Uni-Graft prosthesis, and the preparations obtained showed high stability in the environment with different pH and temperature values. Modification of the Uni-Graft prosthesis surface with the synthetic AEBSF inhibitor and human α1-antitrypsin inhibited the adhesion and multiplication of Staphylococcus aureus subs. aureus ATCC® 25923TM and Candida albicans from the collection of the Department of Genetics and Microbiology, UMCS. Optical profilometry analysis indicated that, after the immobilization process on the surface of AEBSF-modified Uni-Graft prostheses, there were more structures with a high number of protrusions, while the introduction of modifications with a protein inhibitor led to the smoothing of their surface.

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“…Prosthetic joint infection (PJI) is a feared complication of modern orthopaedic surgery that substantially increases morbidity and even mortality following total joint arthroplasty (TJA) [1,2]. Generally, PJI leads to implant removal and long-term antibiotic therapy with a permanent, increased risk for PJI development in affected patients [3].…”

Section: Introductionmentioning

confidence: 99%

Silver Nanocoating Technology in the Prevention of Prosthetic Joint Infection

et al. 2016

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Prosthetic joint infection (PJI) is a feared complication of total joint arthroplasty associated with increased morbidity and mortality. There is a growing body of evidence that bacterial colonization and biofilm formation are critical pathogenic events in PJI. Thus, the choice of biomaterials for implanted prostheses and their surface modifications may significantly influence the development of PJI. Currently, silver nanoparticle (AgNP) technology is receiving much interest in the field of orthopaedics for its antimicrobial properties and a strong anti-biofilm potential. The great advantage of AgNP surface modification is a minimal release of active substances into the surrounding tissue and a long period of effectiveness. As a result, a controlled release of AgNPs could ensure antibacterial protection throughout the life of the implant. Moreover, the antibacterial effect of AgNPs may be strengthened in combination with conventional antibiotics and other antimicrobial agents. Here, our main attention is devoted to general guidelines for the design of antibacterial biomaterials protected by AgNPs, its benefits, side effects and future perspectives in PJI prevention.

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Prosthetic joint infections in the elderly

Abstract: Considering the increase in the number of PJIs in the forthcoming years in most countries, a common action to reduce the associated morbidity and mortality is strongly encouraged in Europe.

Cited by 20 publications

References 67 publications

Osteogenic and bactericidal surfaces from hydrothermal titania nanowires on titanium substrates

Osteogenic and bactericidal surfaces from hydrothermal titania nanowires on titanium substrates

Serine Protease Inhibitors—New Molecules for Modification of Polymeric Biomaterials

Silver Nanocoating Technology in the Prevention of Prosthetic Joint Infection

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