Prosthetic patches for congenital diaphragmatic hernia repair: Surgisis vs Gore-Tex

Diagnosis and management of congenital diaphragmatic hernia: a clinical practice guideline

“…The supportive literature for patch use in CDH consists of cohort studies of low quality. 55,56,[60][61][62] We endorse the use of tension-free or cone-shaped polytetrafluorethylene/ GORE-TEX patches, because of the accumulated experience with their use. We specifically advocate against the use of intestinal submucosal patches alone, as they are associated with an unacceptably high rate of recurrence.…”

Congenital Diaphragmatic Hernia: State of the Art Reconstruction- Biologics Versus Synthetics

“…Since these bioprosthetics are acellular, they are nonimmunogenic. Given the high recurrence rates associated with Gore-Tex®, one study compared Surgisis® (a 4-or 8-ply porcine-derived extracellular matrix from small intestine submucosa) to Gore-Tex® in 72 newborns, reporting no significant difference in recurrence rates (38% and 44%, respectively : Grethel EJ et al, 2006). Graft failures occurred early with 92% of Surgisis® failures and 75% of GoreTex® failures within 1 year.…”

Heparinized collagen scaffolds with and without growth factors for the repair of diaphragmatic hernia

“…Patch materials commonly applied include polytetrafluoroethylene (PTFE) 1 and small intestinal submucosa (SIS), derived from decellularised porcine submucosa. 2 Both types of materials have been found successful in some studies, [3][4][5] but showed high recurrence rates in others. 2,6,7 A recent meta-analysis reported no differences between PTFE and SIS, both materials having a recurrence rate of over 30%.…”

“…2 Both types of materials have been found successful in some studies, [3][4][5] but showed high recurrence rates in others. 2,6,7 A recent meta-analysis reported no differences between PTFE and SIS, both materials having a recurrence rate of over 30%. 7 In case of PTFE patches this may be due to the lack of growth of the material with the child 8 and limited cellular infiltration.…”

“…For SIS, a degradable biological material that may be substituted by the patient's own tissue and thus has the ability to grow with the child, it has been suggested that additional perforation of the material may enhance vascularization. 2 Moreover, it has been suggested that SIS is degraded too fast as the manufacturer indicated resorption of the material in 2 weeks. 7 In a previous study, 10 we have therefore used porous type I collagen bioscaffolds, strengthened by crosslinking, to close surgically created diaphragmatic defects in rats.…”