Prosthetic Valve Endocarditis caused by HACEK Organisms: a Case Report and Systematic Review of the Literature

Choi, Ha Na; Park, Ki Ho; Park, Soyoung; Kim, Jae Min; Kang, Hyun Joon; Park, Jae Hun; Lee, Mi Suk

doi:10.3947/ic.2017.49.4.282

Cited by 7 publications

(15 citation statements)

References 14 publications

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“…Among the cases treated with either procedure, postoperative recovery was good. Another patient underwent surgical intraoperative removal of an infected mitral prosthesis and left upper pulmonary vein thrombus and experienced severe postoperative sequelae [14]. The nal patient had poor mental status and did not undergo surgery, opting instead for subsequent transfer to another hospital [19].…”

Section: Discussionmentioning

confidence: 99%

Infective endocarditis with primary thrombocytopenia caused by Aggregatibacter aphrophilus: a case report

Lou,

Zhao,

Jin

et al. 2023

Preprint

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Background: Infective endocarditis (IE) caused by Aggregatibacteraphrophilus, a member of the normal flora of the human oral cavity and upper respiratory tract, is relatively rare. Usually, patients with IE caused by this bacterium undergo surgical treatment; however, in this case, the patient underwent transcatheter mitral valve repair (TMVR), which differed from previous procedures. Case Presentation: A 63-year-old male patient was hospitalized with a 7-day history of fever. His C-reactive protein and procalcitonin levels were elevated. The blood culture specimens were positive and analyzed using mass spectrometry for the presence of A. aphrophilus. Further esophageal echocardiography confirmed that the patient had IE. The patient's fever resolved after ceftriaxone treatment; however, because of his abnormally low platelet count, he underwent TMVR at an outside hospital. He was followed up for 3 months postoperatively with no significant discomfort. Conclusions: This case is instructive in the surgical management of IE caused by A. aphrophilus and provides a new therapeutic option for high-risk patients in the perioperative period.

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Section: Discussionmentioning

confidence: 99%

Infective endocarditis with primary thrombocytopenia caused by Aggregatibacter aphrophilus: a case report

Lou,

Zhao,

Jin

et al. 2023

Preprint

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“… Native 3 cm x 2.5 cm TV MEM + DO + GEN, NA. - NA 15 ( 17 2017 42/M Fever and jaundice. 17 years: MVR due to rheumatic fever.…”

Section: Literature Reviewmentioning

confidence: 99%

Challenges and Insights in Aggregatibacter aphrophilus endocarditis: a review of literature

Zacarías Mendoza,

Gamarra Valverde,

Robles Velarde

2023

Arch Peru Cardiol Cir Cardiovasc

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Infective endocarditis is a serious disease associated with high mortality despite recent advances in diagnosis and treatment. Aggregatibacter aphrophilus is a fastidious Gram-negative member of the HACEK organisms (Haemophilus spp., Aggregatibacter actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella kingae). A. aphrophilus is associated with dental infections but has also been implicated in cases of infective endocarditis. We highlight the importance of a high index of suspicion in symptomatic patients with an initial negative blood culture, particularly in high-risk groups such as patients with congenital valve disease and prosthetic valve. The knowledge of this rare entity may lead to early diagnosis and appropriate management. We review the main characteristics of Aggregatibacter aphrophilus endocarditis reported in the medical literature.

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“…However, in up to 20 % of cases of IE, cultures come back negative, and no causal agent can be identified (1) . One important group of bacteria to consider in these cases is the HACEK group (5) . HACEK is an acronym comprising the first letters of the generic names of the following group of bacteria: Haemophilus, Aggregatibacter, Cardiobacterium., Eikenella and Kingella.…”

Section: Introductionmentioning

confidence: 99%

“…These organisms are fastidious Gram-negative bacteria found in the human upper respiratory and genitourinary tracts. It accounts for only 3 % of cases of IE (1,3,6) , and only 1.4 % of prosthetic valve endocarditis (PVE) (5,7) .…”

Section: Introductionmentioning

confidence: 99%

“…The diagnosis of IE typically requires a combination of clinical, microbiological, and imaging results (1) . Furthermore, the diagnosis of device-associated IE or PVE, is even more challenging, since classical and modified Duke criteria lack sensitivity (5,8) . Transesophageal echocardiography (TEE) becomes a valuable tool in all cases of suspected device-associated IE, as detection of vegetations may be difficult due to artifacts, and therefore a negative transthoracic echocardiography (TTE) cannot be considered a rule out.…”

Section: Introductionmentioning

confidence: 99%

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A Rare Case of HACEK Endocarditis in the Context of a Permanent Pacemaker

Echavarria Cross,

Escobar Gil,

Roncancio Villamil

et al. 2023

CES Med

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Introduction: Infective endocarditis (IE) is a serious medical condition that can lead to high morbidity and mortality rates. The prevalence of healthcare-associated IE is increasing due to the use of therapeutic devices, such as intravascular catheters and cardiac devices. The HACEK group of bacteria, are commonly found in human respiratory and genitourinary tracts, are low virulence and fastidious organisms that are associated with blood culture-negative endocarditis. Proper diagnosis requires a combination of clinical, microbiological, and imaging results. The following study presents a case of atypical device-associated IE caused by Haemophilus influenzae in a 56-year-old man with a permanent pacemaker. Methodology: description of a clinical problem, its diagnosis, management, and outcome, accompanied with a literature review. Conclusion: This study highlights the importance of considering the HACEK group of bacteria in culture-negative IE cases and the use of advanced imaging techniques in diagnosis to prevent further complications and improve patient outcomes.

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Prosthetic Valve Endocarditis caused by HACEK Organisms: a Case Report and Systematic Review of the Literature

Cited by 7 publications

References 14 publications

Infective endocarditis with primary thrombocytopenia caused by Aggregatibacter aphrophilus: a case report

Infective endocarditis with primary thrombocytopenia caused by Aggregatibacter aphrophilus: a case report

Challenges and Insights in Aggregatibacter aphrophilus endocarditis: a review of literature

A Rare Case of HACEK Endocarditis in the Context of a Permanent Pacemaker

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