Prosthetic valve thrombosis: A regimen of treatment with low-dose and longer-course using recombinant tissue-type plasminogen activator is a promising protocol

Caceres-Loriga, Fidel Manuel; Pérez-López, Horacio; Morlans-Hernández, Karel

doi:10.1016/j.jtcvs.2008.03.070

Cited by 2 publications

(3 citation statements)

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“…Heparin therapy continued until an international normalized ratio (INR) of Ն2.5 was achieved. The regimen used is adapted from the study by Cáceres-Lóriga et al 4 TTE and fluoroscopy were performed at 12th, 24th, and 14th hour of treatment. Fibrinogen levels, aPTT, and INR values were recorded during treatment.…”

Section: Description Of Cases and Resultsmentioning

confidence: 99%

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Treatment of Mechanical Aortic Valve Thrombosis Fibrinolytic Treatment versus Surgical Intervention: Result of Eight Cases

Yay

Boysan

İrdem

et al. 2010

Innovations�(Phila)

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Objective Thrombosis of mechanical heart valve prosthesis is a rare fatal complication after heart valve replacement. Although surgical intervention is the suggested treatment in many series, fibrinolytic treatment offers a good alternative. We describe eight cases with mechanical aortic valve thrombosis and compare their results after fibrinolytic treatment or redo aortic valve replacement. Methods Between February 2008 and March 2009, eight patients with previous mechanical prosthetic aortic valve replacement history were admitted to our center with mechanical aortic valve thrombosis. Four patients were operated, and the remaining four patients received low-dose fibrinolytic treatment. All patients’ data were collected prospectively. Results Two of the four operated patients died. In the fibrinolytic group, all patients totally recovered, and there was no mortality or morbidity during the follow-up period. Conclusions We thought that fibrinolytic treatment is a feasible and effective method for thrombosed mechanical aortic valve. However, much more populated patient groups are needed for the vigorous inference.

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Section: Description Of Cases and Resultsmentioning

confidence: 99%

“…17 There is a case report that showed that recombinant t-PA administration had better results. 18 Cáceres-Lóriga et al 4 tried a low-dose, longer-course regimen with recombinant t-PA and achieved promising results with fewer complications.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Mechanical Aortic Valve Thrombosis Fibrinolytic Treatment versus Surgical Intervention: Result of Eight Cases

Yay

Boysan

İrdem

et al. 2010

Innovations�(Phila)

View full text Add to dashboard Cite

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“…[19]. The use of recombinant tissue-type plasminogen activator is still less common than the use of Streptokinase for the treatment of prosthetic valve thrombosis [20] with two main regimens, the 100 mg loading dose over 90 minutes [2] versus the 1 mg/hour continuous infusion over 80 hours [21]. Those two methods have not been compared so far ( Table 1).…”

Section: Discussionmentioning

confidence: 99%

Successful Thrombolytic Treatment of a Thrombosed Mechanical Mitral Valve in a Post-brain Surgery Patient- A Case Report and Literature Review

Alshamiri¹

2019

Angiol Open Access

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The first-line management of prosthetic valve thrombosis is not yet finalized; dealing with such cases remains a clinical challenge and requires prompt detection, timely diagnosis and individualized case management regardless of whether the case in question requires a surgical or medical therapeutic approach. We report a unique case of mechanical mitral valve thrombosis post Bentall procedure with a double aortic-mitral valve replacement in a patient who previously underwent brain surgery after experiencing a Road Traffic Accident (RTA). The patient was successfully treated by using a combined loading and infusion regimen of tissue-Plasminogen Activators (t-PA). A small loading dose of 15 mg followed by a low-dose slow infusion of t-PA has been shown to provide effective and safe thrombolysis in high-risk patients with prosthetic valve thrombosis.

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Prosthetic valve thrombosis: A regimen of treatment with low-dose and longer-course using recombinant tissue-type plasminogen activator is a promising protocol

Cited by 2 publications

References 5 publications

Treatment of Mechanical Aortic Valve Thrombosis Fibrinolytic Treatment versus Surgical Intervention: Result of Eight Cases

Treatment of Mechanical Aortic Valve Thrombosis Fibrinolytic Treatment versus Surgical Intervention: Result of Eight Cases

Successful Thrombolytic Treatment of a Thrombosed Mechanical Mitral Valve in a Post-brain Surgery Patient- A Case Report and Literature Review

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