Protamine-grafted carboxymethyl chitosan based hydrogel with adhesive and long-term antibacterial properties for hemostasis and skin wound healing

Mo, Zhendong; Ma, Yahao; Chen, Wenjie; You, Lifang; Liu, Wenran; Zhou, Qing; Zeng, Zheng; Chen, Tianyin; Li, Hang; Tang, Shunqing

doi:10.1016/j.carbpol.2024.122125

Cited by 9 publications

(1 citation statement)

References 42 publications

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“…We investigated and compared the antibiofilm performance of other biofilm inhibition methods developed using environmentally friendly and/or nontoxic approaches. As shown in Table S1, the majority of antibiofilm approaches based on environmentally friendly or nontoxic approaches demonstrated only short-term inhibition performance within 24 h with reductions of 80–99.6%, while some demonstrated long-term performance of approximately 5–7 days with reductions of 75–97.2%. − In comparison, our hybrid approach demonstrated a reduction of 97.7% over 7 days of incubation, validating the long-term biofilm resistance of the slippery composites based on the hybrid approaches. Additionally, the PDMS-CTS-MSN-SO composite also showed excellent long-term antibiofilm efficacy against the Gram-positive bacteria of S. aureus with overall similar trends for Gram-negative bacteria of E. coli (Figure S6).…”

Section: Resultssupporting

confidence: 57%

Sustainable Biofilm Inhibition Using Chitosan-Mesoporous Nanoparticle-Based Hybrid Slippery Composites

Jang,

Song,

Song

et al. 2024

ACS Appl. Mater. Interfaces

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In recent decades, extensive research has been directed toward mitigating microbial contamination and preventing biofilm formation. However, many conventional antibiofilm methods rely on hazardous and toxic substances, neglecting potential risks to human health and the environment. Moreover, these approaches often rely on singlestrategy mechanisms, utilizing either bactericidal or fouling-resistant agents, which have shown limited efficacy in long-term biofilm suppression. In this study, we propose an efficient and sustainable biofilm-resistant slippery hybrid slippery composite. This composite integrates nontoxic and environmentally friendly materials including chitosan, silicone oil-infused polydimethylsiloxane, and mesoporous silica nanoparticles in a synergistic manner. Leveraging the bacteria-killing properties of chitosan and the antifouling capabilities of the silicone oil layer, the hybrid composite exhibits robust antibiofilm performance against both Gram-positive and Gram-negative bacteria. Furthermore, the inclusion of mesoporous silica nanoparticles enhances the oil absorption capacity and self-replenishing properties, ensuring exceptional biofilm inhibition even under harsh conditions such as exposure to high shear flow and prolonged incubation (7 days). This approach offers promising prospects for developing effective biofilm-resistant materials with a reduced environmental impact and improved long-term performance.

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